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Keywords: CpG island
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Articles
Biochem Soc Trans (2024) 52 (1): 151–161.
Published: 30 January 2024
... 11 2023 3 1 2024 5 1 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 CpG island H2AK119ub1 H3K27me3 PRC1 PRC2 transcriptional repression The Polycomb group (PcG) was identified in the 1940s as a group...
Articles
Biochem Soc Trans (2013) 41 (3): 727–740.
Published: 23 May 2013
...-modifying activities that are thought to contribute to transcriptional repression and maintain heterochromatic regions of the genome. In contrast with DNA methylation, which is found broadly across vertebrate genomes, non-methylated DNA is concentrated in regions known as CGIs (CpG islands). Recently...
Articles
Biochem Soc Trans (2005) 33 (4): 684–688.
Published: 01 August 2005
...–adenocarcinoma sequence and are believed to drive the histological progression of colon cancer. Recently, epigenetic alterations, which include CGI (CpG island) DNA methylation, have been shown to occur in colon polyps and colon cancer. The aberrant methylation of genes appears to co-operate with the genetic...
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Articles
Biochem Soc Trans (2004) 32 (6): 916–917.
Published: 26 October 2004
...J.M. Teodoridis; G. Strathdee; J.A. Plumb; R. Brown Aberrant methylation of CpG islands (CpG-rich regions of DNA associated with the promoters of many genes) is associated with transcriptional inactivation of genes involved in tumour development. Genes involved in key DNA damage response pathways...
Articles
Biochem Soc Trans (2004) 32 (6): 913–915.
Published: 26 October 2004
...G. Strathdee; A. Sim; R. Brown The role of DNA methylation in the control of mammalian gene expression has been the subject of intensive research in recent years, partly due to the critical role of CpG island methylation in the inactivation of tumour suppressor genes during the development...