... to develop a compound that would modulate selectively the activity of the disease-causing Rab7 mutant proteins and not of the wild-type. autophagy Charcot–Marie–Tooth disease endocytosis peripheral neuropathy Rab7 Rab7a Figure 2 Altered autophagy process in neurodegenerative diseases...

... in view of the fact that Rab7 is a ubiquitous protein. The present review discusses possible molecular mechanisms underlying CMT2B. © The Authors Journal compilation © 2009 Biochemical Society 2009 Charcot–Marie–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein...