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Keywords: Cdx2
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Biochem Soc Trans (2010) 38 (2): 358–363.
Published: 22 March 2010
... played by CDX2 ( Caudal -type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular...
Biochem Soc Trans (2010) 38 (2): 313–319.
Published: 22 March 2010
... of the tissue. A macroscopic patch of metaplastic tissue will arise only if the new gene activity state is self-sustaining in the absence of its original causes, and if the new tissue type can outgrow the parent tissue type. An important candidate gene for the causation of Barrett's metaplasia is Cdx2 ( Caudal...
Biochem Soc Trans (2010) 38 (2): 364–369.
Published: 22 March 2010
... a rapidly rising incidence and a dismal prognosis. The homoeotic transcription factor Cdx2 ( Caudal -type homeobox 2) has been implicated as a master switch gene for intestine and therefore for Barrett's metaplasia. Normally, Cdx2 expression is restricted to the epithelium of the small and large intestine...