...Natasha P. Murphy; Ana Masara binti Ahmad Mokhtar; Helen R. Mott; Darerca Owen Cdc42 is a member of the Rho family of small GTPases and a master regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. This small G protein and its regulators have been...

..., largely of the oncogenic family members, STAT3 and STAT5, are being identified. Cdc42, Rac1, RhoA, RhoC and RhoH have all been implicated in STAT activation, contributing to Rho GTPase-driven changes in cellular morphology that lead to cell proliferation, invasion and metastasis. This highlights...

... on behalf of the Biochemical Society 2018 CDC42 GTPase RAC RHO RHO GAP RHO GEF The 18 RHO GTPases present in humans can be classified according to both structural and homology criteria in the CDC42 (CDC42, RHOQ, and RHOJ), RAC (RAC1, RAC2, RAC3, and RHOG), RHOA (RHOA, RHOB, and RHOC...

...Aaron J. Farrugia; Fernando Calvo Despite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1–5) remains largely uncharacterised and relatively little is known about their structure, regulation and role in development and disease...

...Sergio A. Rincón; Miguel Estravís; Pilar Pérez Polarized cell growth requires a well-orchestrated number of events, namely selection of growth site, organization of cytoskeleton elements and delivery of new material to the growth region. The small Rho GTPase Cdc42 has emerged as a major organizer...

... © The Authors Journal compilation © 2014 Biochemical Society 2014 Candida albicans Cdc42 filamentous growth G-protein phospholipid Saccharomyces cerevisiae A number of fungi can grow by asexual reproduction via budding growth, in which a small bud is formed on a mother cell...

...Maitreyi Das; Fulvia Verde Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self...

..., and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders. 1 email halla@mskcc.org 24 4 2012 © 2012 The Authors Journal 2012 actin cytoskeleton Cdc42 GTPase Rac Rho Rho GTPases constitute one of the five distinct families of the Ras superfamily...

... dynamics in vivo . Inactive dimeric Pak1 is mainly cytosolic. Localized interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions. Moreover, Pak1 is dynamically engaged into multiprotein complexes forming adhesions to the extracellular matrix. Cutting...

... or protrusions, where they co-localized with RhoG or Cdc42, probably identifying for the first time the site of extraction of a Rho protein by a rhoGDI in vivo . We propose that these mutations act by modifying the steady-state kinetics of the shuttling process regulated by rhoGDIs, such that transient steps...

... Rac1 and Cdc42 activities are high only at the leading edge. In cells stimulated with epidermal growth factor or nerve growth factor, activities of Rac1 and Cdc42 were transiently elevated in a broad area of the plasma membrane, followed by a localized activation at nascent lamellipodia. In contrast...

... discuss the different types of filopodial structures, together with the actin-binding proteins and signalling pathways involved in their formation. Specifically, we highlight the differences between the filopodial extensions induced by the Rho GTPases Cdc42 and Rif. 1 To whom correspondence should...