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Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 72–77.
Published: 19 January 2010
... cohesion between sister chromatids, preventing anaphase onset. The spindle checkpoint is a signalling pathway emerging from improperly attached chromosomes that inhibits Cdc20, the mitotic activator of the APC/C (anaphase-promoting complex/cyclosome) ubiquitin ligase. Blocking Cdc20 stabilizes cyclin B1...