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Keywords: Caenorhabditis elegans
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Articles
Biochem Soc Trans (2022) 50 (5): 1517–1526.
Published: 05 October 2022
...Wei Cao; Roger Pocock Animals constantly encounter environmental and physiological stressors that threaten survival and fertility. Somatic stress responses and germ cell arrest/repair mechanisms are employed to withstand such challenges. The Caenorhabditis elegans germline combats stress...
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Biochem Soc Trans (2020) 48 (3): 1243–1253.
Published: 29 June 2020
...Sukriti Kapoor; Sachin Kotak Cellular asymmetries are vital for generating cell fate diversity during development and in stem cells. In the newly fertilized Caenorhabditis elegans embryo, centrosomes are responsible for polarity establishment, i.e. anterior–posterior body axis formation. The signal...
Articles
Biochem Soc Trans (2020) 48 (3): 1019–1034.
Published: 15 June 2020
...Rachel M. Woodhouse; Alyson Ashe Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful...
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Articles
Biochem Soc Trans (2013) 41 (4): 821–824.
Published: 18 July 2013
...Amy E. Pasquinelli The let-7 miRNA (microRNA) is an essential regulator of development from nematode worms to humans. Altered expression of let-7 results in larval arrest or lethality in Caenorhabditis elegans. Likewise, under- or over-expression of let-7 in human cells can result in cellular...
Articles
Biochem Soc Trans (2011) 39 (6): 1705–1709.
Published: 21 November 2011
... analysis of Caenorhabditis elegans lamin [ 6 , 7 ]. The 10 nm intermediate filament-like lamin structure is made of tetrameric protofilaments, each composed of two antiparallel head-to-tail lamin dimer polymers [ 5 ]. Mutations in human LMNA , which encodes lamins A and C, cause numerous different...
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Articles
Biochem Soc Trans (2010) 38 (1): 172–176.
Published: 19 January 2010
... research has focused primarily on postsynaptic targets. Recent research using the model organism Caenorhabditis elegans has determined a role for specific proteins (Munc18-1 and Rab3) and processes (synaptic vesicle recruitment and fusion) in transducing the presynaptic effects of ethanol. In the present...
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Articles
Biochem Soc Trans (2007) 35 (1): 129–132.
Published: 22 January 2007
...H.A. Baylis; K. Goyal The nematode Caenorhabditis elegans contains over 20 genes for TRP (transient receptor potential) channels which include members of all of the subclasses identified in mammalian cells. These proteins include three members of the TRPM (TRP melastatin) family: gon - 2 (abnormal...
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Articles
Biochem Soc Trans (2006) 34 (1): 77–80.
Published: 20 January 2006
...E. Marza; G.M. Lesa Changes in PUFA (polyunsaturated fatty acid) metabolism can cause mental retardation and cognitive impairment. However, it is still unclear why altered levels of PUFAs result in neuronal dysfunction. Recent studies on the nematode Caenorhabditis elegans suggest that PUFA...
Articles
Biochem Soc Trans (2006) 34 (1): 64–67.
Published: 20 January 2006
... properly. Understanding the molecular architecture of functional glutamatergic synapses is therefore an important challenge in neurobiology. To address this question, we combine the techniques of genetics, molecular biology and electrophysiology in the nematode Caenorhabditis elegans . To date, genetic...
Articles
Biochem Soc Trans (2005) 33 (4): 606–608.
Published: 01 August 2005
...D. Poteryaev; A. Spang Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have...
Articles
Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
...J.N. Sampayo; M.S. Gill; G.J. Lithgow To date, more than 40 genes have been identified in the nematode Caenorhabditis elegans , which, when mutated, lead to an increase in lifespan. Of those tested, all confer an increased resistance to oxidative stress. In addition, the lifespan of C. elegans can...
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Articles
Biochem Soc Trans (2000) 28 (6): 751–752.
Published: 01 December 2000
... cloned and functionally expressed one of the three putative glucosylceramide synthases from Caenorhabditis elegans as well as a corresponding enzyme from Pichia pastoris. 1 To whom correspondence should be addressed (e-mail eheinz@botanik.uni-hamburg.de ) 30 6 2000 © 2000 Biochemical...