...Wei Cao; Roger Pocock Animals constantly encounter environmental and physiological stressors that threaten survival and fertility. Somatic stress responses and germ cell arrest/repair mechanisms are employed to withstand such challenges. The Caenorhabditis elegans germline combats stress...

...Sukriti Kapoor; Sachin Kotak Cellular asymmetries are vital for generating cell fate diversity during development and in stem cells. In the newly fertilized Caenorhabditis elegans embryo, centrosomes are responsible for polarity establishment, i.e. anterior–posterior body axis formation. The signal...

...Rachel M. Woodhouse; Alyson Ashe Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful...

...Kim B. Pho; Lesley T. MacNeil Reproducibility is critical for the standardization, interpretation, and progression of research. However, many factors increase variability and reduce reproducibility. In Caenorhabditis elegans research, there are many possible causes of variability that may explain...

...Amy E. Pasquinelli The let-7 miRNA (microRNA) is an essential regulator of development from nematode worms to humans. Altered expression of let-7 results in larval arrest or lethality in Caenorhabditis elegans. Likewise, under- or over-expression of let-7 in human cells can result in cellular...

..., providing a potential mechanism for how these mutations lead to tissue-specific diseases. 1 To whom correspondence should be addressed (email gru@vms.huji.ac.il ). 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Caenorhabditis elegans chromatin DNA...

... model is needed to investigate the molecular determinants of these debilitating diseases. Mammalian models are often prohibitively expensive, time-consuming and very complex. Given the highly conserved neurological pathways between mammals and invertebrates, Caenorhabditis elegans has emerged...

... research has focused primarily on postsynaptic targets. Recent research using the model organism Caenorhabditis elegans has determined a role for specific proteins (Munc18-1 and Rab3) and processes (synaptic vesicle recruitment and fusion) in transducing the presynaptic effects of ethanol. In the present...

...T.L. Crum; P.G. Okkema T-box transcription factors are crucial developmental regulators, and they have not previously been associated with SUMOylation. In Caenorhabditis elegans , the Tbx2 subfamily member TBX-2 (T-box protein 2) is required for anterior pharyngeal muscle development. TBX-2...

...H.A. Baylis; K. Goyal The nematode Caenorhabditis elegans contains over 20 genes for TRP (transient receptor potential) channels which include members of all of the subclasses identified in mammalian cells. These proteins include three members of the TRPM (TRP melastatin) family: gon - 2 (abnormal...

... Caenorhabditis elegans , but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl - 1 , mgl - 2 and mgl - 3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls . Our results...

... properly. Understanding the molecular architecture of functional glutamatergic synapses is therefore an important challenge in neurobiology. To address this question, we combine the techniques of genetics, molecular biology and electrophysiology in the nematode Caenorhabditis elegans . To date, genetic...

...E. Marza; G.M. Lesa Changes in PUFA (polyunsaturated fatty acid) metabolism can cause mental retardation and cognitive impairment. However, it is still unclear why altered levels of PUFAs result in neuronal dysfunction. Recent studies on the nematode Caenorhabditis elegans suggest that PUFA...

...D. Poteryaev; A. Spang Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have...

...J.N. Sampayo; M.S. Gill; G.J. Lithgow To date, more than 40 genes have been identified in the nematode Caenorhabditis elegans , which, when mutated, lead to an increase in lifespan. Of those tested, all confer an increased resistance to oxidative stress. In addition, the lifespan of C. elegans can...

... signalling complexes with specific fibroblast growth factors and their receptors. Regulated synthesis of specific HS species could be a mechanism for the regulation of proliferation and differentiation in the developing brain. We also describe evidence that a Caenorhabditis elegans orthologue...

... cloned and functionally expressed one of the three putative glucosylceramide synthases from Caenorhabditis elegans as well as a corresponding enzyme from Pichia pastoris. 1 To whom correspondence should be addressed (e-mail eheinz@botanik.uni-hamburg.de ) 30 6 2000 © 2000 Biochemical...