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Keywords: CUG repeat
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Biochem Soc Trans (2009) 37 (6): 1281–1286.
Published: 19 November 2009
... mechanism of this disease involves the RNA transcribed from the expanded allele containing long tracts of (CUG) n or (CCUG) n . The RNA results in a toxic effect through two RNA-binding proteins: MBNL1 (muscleblind-like 1) and CUGBP1 (CUG-binding protein 1). In DM1, MBNL1 is sequestered on CUG repeat...