... the haematopoietic fate. Understanding how to modulate the requirement for TGFβ signalling in HSC emergence may have critical implications for the generation of these cells in vitro for therapeutic use. BMP endothelial to haematopoietic transition haemogenic endothelium mouse models TGFβ zebrafish...

...Sylvain Lefort; Véronique Maguer-Satta The bone morphogenetic protein (BMP) pathway regulates the fate and proliferation of normal hematopoietic stem cells (HSC) as well as interactions with their niche. While BMP2 and BMP4 promote HSC differentiation, only BMP4 maintains HSC pool and favors...

... for marketing. This can extend for up to 12 years within the European Union and therefore compares favourably with the term remaining on most patents upon marketing [ 59 ]. BMP brain tumour cancer drug development glioma kinase Correspondence: Alex N. Bullock ( alex.bullock@sgc.ox.ac.uk...