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Keywords: BCL-2
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Articles
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Published: 28 September 2021
...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...
Articles
Biochem Soc Trans (2021) 49 (5): 2381–2395.
Published: 13 September 2021
...Erinna F. Lee; W. Douglas Fairlie The discovery of a new class of small molecule compounds that target the BCL-2 family of anti-apoptotic proteins is one of the great success stories of basic science leading to translational outcomes in the last 30 years. The eponymous BCL-2 protein was identified...
Articles
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has...
Articles
Biochem Soc Trans (2007) 35 (5): 1009–1012.
Published: 25 October 2007
... correspondence should be addressed (email a.michie@udcf.gla.ac.uk ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Bcl-2 B-lymphocyte chronic lymphocytic leukaemia (CLL) microRNA murine model T-cell leukaemia/lymphoma-1 (Tcl-1) CLL (chronic...
Articles
Biochem Soc Trans (2007) 35 (5): 1038–1039.
Published: 25 October 2007
...Y. Lao; D.C. Chang Recently, it was found that Bcl-2 family proteins can affect the apoptotic process by modifying Ca 2+ released from the ER (endoplasmic reticulum). In this review, we summarize the evidence that Bcl-2 and Bax can modulate Ca 2+ mobilization from the ER to the cytosol...
Articles
Biochem Soc Trans (2004) 32 (3): 461–464.
Published: 01 June 2004
... of neutrophil numbers in the circulation, the efficient removal of invading pathogens and resolution of the inflammatory response. Key words: apoptosis, Bcl-2, caspase 8, death receptor, lipid raft, inflammation, neutrophil. Abbreviations used: DISC, death-inducing signalling complex; DR, death receptor; FADD...
Articles
Biochem Soc Trans (2004) 32 (3): 489–492.
Published: 01 June 2004
...S.W. Edwards; M. Derouet; M. Howse; R.J. Moots Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role...
Articles
Biochem Soc Trans (2004) 32 (3): 480–484.
Published: 01 June 2004
... protein kinase B (also known as c-akt), has been demonstrated to be important in modulating the prosurvival effects of PI3K activation. This can occur through modulation of the expression or phosphorylation of members of the Bcl-2 (B-cell lymphocytic-leukaemia proto-oncogene 2) family of apoptosis...
Articles
Biochem Soc Trans (2003) 31 (5): 958–959.
Published: 01 October 2003
...C.W. Distelhorst; H.L. Roderick In this review we speculate that the anti-apoptotic protein Bcl-2 may regulate calcium signals involved in mediating cell death. Evidence that Ins(1,4,5) P 3 -mediated calcium release from the endoplasmic reticulum triggers apoptosis in response to diverse signals...