... ample evidence that tetraspanins on B-lymphocytes are important in controlling antibody production. The tetraspanin CD81 interacts with the BCR complex and is critical for CD19 expression and IgG production, whereas the tetraspanin CD37 inhibits IgA production and is important for IgG production...

...A.M. Michie; R. Nakagawa; A.M. McCaig CLL (chronic lymphocytic leukaemia) is characterized by the clonal outgrowth of B-lymphocytes with the distinctive phenotype: CD19 hi CD5 + CD23 + IgM lo . These malignant B-cells accumulate in the PB (peripheral blood) and lymphoid organs, and are generally...

... functions in B-lymphocyte activation. Present results support the view that Bam32/DAPP1 mediates multiple PI3K-dependent responses in B-cells through membrane-proximal mechanisms involving Src kinases, Rac1, F-actin and mitogen-activated protein kinases, resulting in selective effects on BCR-mediated...

...). The blots were subsequently stripped and re-probed with antibodies to Vav1 or PKB respectively. ( B ) Wild-type or p110δ-deficient B-cells were stimulated with F(ab) 2 α-IgM (10 μg/ml) for the indicated time points, lysed and blotted as indicated in ( A ). B-lymphocyte phosphoinositide 3-kinase...

... B-cell receptor B-lymphocyte Fc receptor phosphatase signal transduction Abbreviations used: BCR, B-cell antigen receptor; BM, bone marrow; [Ca 2+ ] i , intracellular calcium concentration; ERK, extracellular signal-related protein kinase; FcR, Fc receptor; IL, interleukin; IMDM...

... of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, U.S.A. (e-mail michael.holers@uchsc.edu ) © 2002 Biochemical Society 2002 B-lymphocyte co-crystal structure complement control protein innate immunity CR, complement receptor EBV, Epstein-Barr virus FDC...