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Keywords: B-cell selection
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Biochem Soc Trans (2021) 49 (3): 1467–1478.
Published: 01 July 2021
..., the immune system has evolved a powerful mechanism to eliminate autoreactive B-cells, termed negative B-cell selection. While designed to remove autoreactive clones during early B-cell development, our laboratory recently discovered that transformed B-cells in leukemia and lymphoma are also subject...