... with AD or whether it rather reflects non-specific neuronal damage. 1 To whom correspondence should be addressed (email j.attems@ncl.ac.uk ). 2 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 Alzheimer's disease (AD) Braak stages brainstem...

... Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) central nervous system (CNS) microglial cell systemic inflammation In humans, evidence of communication between systemic inflammation and the CNS (central nervous system) is visible...

... The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid-binding alcohol dehydrogenase (ABAD) cyclohexenyl amine naphthalene alcohol (CHANA) cyclophilin D (CypD) intracellular amyloid β-peptide (intracellular Aβ) mitochondrial dysfunction References...

... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration AD (Alzheimer's disease) causes...

... disease (AD) animal model delirium dementia microglia microglial priming systemic inflammation It has been known for many years that inflammation has a role in the progression of AD (Alzheimer's disease). Patients taking NSAIDs (non-steroidal anti-inflammatory drugs) for the amelioration...

... compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) amyloid precursor protein (APP) human pathology intraneuronal amyloid β-peptide (intraneuronal Aβ) neuron loss AD (Alzheimer's disease) represents the most frequent form of dementia...

... analogues have shown similar effects in an APP/PS1 mouse model of AD. Injection of the GIP peptide intraperitoneal had protective effects on spatial learning in memory tasks and also reduced plaque formation and amyloid load [ 45 ]. Alzheimer's disease (AD) central nervous system (CNS) glucagon-like...

... neurodegeneration, whereas genetic deletion of neuronal 26S proteasomes does, as well as some hallmarks of human disease. © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid deposit chronic neurodegenerative disease gliosis neuron Chronic...

... correspondence should be addressed (email b.platt@abdn.ac.uk ). 16 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) imaging positron-emission tomography (PET) power spectrum quantitative electroencephalogram sleep Translational...

... Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) dentate gyrus (DG) episodic-like memory hippocampal synaptic activity pattern separation There is converging evidence from both human and animal studies that the initial stages of AD...

... The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) amyloid β-peptide (Aβ) axon–glial integrity hypoperfusion vascular disease white matter The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining...

... disease (AD) amyloid β-peptide (Aβ) arterial hypertension lipopolysaccharide murine model AD is the leading cause of dementia in the elderly and, although some treatments help the symptoms and slow the progression of the disease, no definitive cure exists. Early-onset/genetic AD accounts...

.... Hanson K.A. Williams L.M. Sakasai R. Bowler M.J. Tibbetts R.S. Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1 J. Biol. Chem. 2009 284 8083 8092 aggresome Alzheimer's disease (AD...

... in BACE expression, in post-mortem brain tissue and platelets from individuals with AD. © 2005 The Biochemical Society 2005 Alzheimer's disease (AD) amyloid precursor protein (APP) β-site amyloid precursor protein-cleaving enzyme (BACE) cholesterol platelet post-mortem brain protease...

... should be addressed (email s.j.patey@liv.ac.uk ). 27 6 2005 © 2005 The Biochemical Society 2005 Alzheimer's disease (AD) amyloid precursor protein (APP) BACE1 (β-secretase 1) fibrillogenesis glycosaminoglycan (GAG) heparan sulphate (HS) AD is characterized by amyloid...

... To whom correspondence should be addressed (email tjnelson@brni-jhu.org ). 17 6 2005 © 2005 The Biochemical Society 2005 Alzheimer's disease (AD) β-amyloid cholesterol insulin memory protein kinase C (PKC) Both insulin and cholesterol have long been considered part...

...Sarah L. Houldsworth; Alison J. Trew; Nigel M. Hooper; Anthony J. Turner © 1998 Biochemical Society 1998 Alzheimer's disease (AD) β-amyloid protein (βA4) β-amyloid precursor protein (β-APP) angiotensin converting enzyme (ACE) Hip, hippuryl 665th Meeting Southampton: 665th...

...RUTH M. DUBERLEY; CAROLE R. RICKARDS; JACK HAM; MAURICE F. SCANLON © 1993 Biochemical Society 1993 Alzheimer's Disease (AD) N-methyl-D-aspartate (NMDA) Kainic acid (KA) Quisqualate (Q) Choline acetyltransferase (CHAT) muscarinic acetylcholine receptor (mAchr) inositol monophosphate...