... is induced rapidly and transiently in response to a plethora of stimuli; (ii) COX - 2 mRNA stability and translational efficiency is governed by multiple regulatory elements within the 3′-untranslated region; (iii) specific microRNAs and RNA-binding proteins influence COX - 2 mRNA stability; and (iv...

... of mammalian cells and are associated with the cytoskeleton. Targeting of these mRNAs to the perinuclear cytoplasm is mediated by elements within their 3′-UTRs (3′-untranslated regions), but many of the trans -acting proteins remain unidentified. UV cross-linking assays using radiolabelled transcripts...

...J. Hesketh There is increasing evidence that 3′-UTRs (3′-untranslated regions) of mRNAs contain regulatory elements that have important roles in post-transcriptional control of gene expression. For example, 3′-UTRs are important in determining mRNA localization and directing selenocysteine...