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Keywords: 2-hydroxyglutarate
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2561–2572.
Published: 02 December 2021
..., in a breakthrough study the R132H IDH1 variant was shown to enhance the production of the endogenous metabolite 2-hydroxyglutarate (2HG), which was observed to accumulate to concentrations in the range 3–35 µM/g of tumour in patient R132H IDH1 glioma tissues, whilst wild-type IDH1 tumours manifested over 100-fold...
