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Keywords: β-catenin
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Articles
Biochem Soc Trans (2020) 48 (3): 1187–1198.
Published: 15 May 2020
...Pablo Astudillo The Wnt/β-catenin signaling pathway plays fundamental roles during development, stem cell differentiation, and homeostasis, and its abnormal activation can lead to diseases. In recent years, it has become clear that this pathway integrates signals not only from Wnt ligands but also...
Articles
Biochem Soc Trans (2010) 38 (5): 1281–1285.
Published: 24 September 2010
...Bente Kofahl; Jana Wolf The Wnt/β-catenin pathway plays an important role in development and disease. Theoretical approaches have been used to describe this pathway and have provided intriguing insights into its signalling characteristics. In the present paper, we review mathematical models...
Articles
Biochem Soc Trans (2008) 36 (6): 1354–1358.
Published: 19 November 2008
... on a possible role of an emerin–β-catenin interaction in the pathogenesis of this disease. To propose a role for emerin–β-catenin, we first summarize the known functions of β-catenin in the heart. β-Catenin is a key mediator of early heart development and is required for both physiological and pathological...
Articles
Biochem Soc Trans (2005) 33 (4): 672–675.
Published: 01 August 2005
... (adenomatous polyposis coli) genes occur early in the development of CRC and lead to the stabilization of the Wnt pathway component β-catenin and to the constitutive activation of Wnt signalling. Stabilizing mutations of β-catenin can also lead to its accumulation, qualifying β-catenin as a proto-oncogene...
Articles
Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
... a single gene, we have produced many of the phenotypes that are associated with early colorectal lesions: failed differentiation, increased proliferation, aberrant migration and loss of euploidy. Furthermore, we show a large number of molecular changes centring on activation of β-catenin/TCF4 transcription...
Articles
Biochem Soc Trans (2005) 33 (4): 698–700.
Published: 01 August 2005
... stimulation, β-catenin is translocated to the nucleus, triggering the transcriptional activity of the TCF (T-cell factor)/LEF (lymphoid enhancer factor) family of transcription factors. These events are dependent on phosphoinositide-3 kinase activation and glycogen synthase kinase inhibition. Our data suggest...
Articles
Biochem Soc Trans (2004) 32 (5): 803–808.
Published: 26 October 2004
... 2004 β-catenin diabetes glycogen protein kinase Figure 2 Regulation of GSK-3 by the insulin signal-transduction pathway The binding of insulin to its cell-surface receptor triggers the recruitment and activation of PI3K. At the plasma membrane, PI3K stimulates the formation of PtdIns...
Articles
Biochem Soc Trans (2004) 32 (5): 797–798.
Published: 26 October 2004
...E.D. Martin; M. Grealy Plakoglobin (γ-catenin) and β-catenin are major components of the adherens junctions and can be localized to the nucleus by activation of the Wnt signalling pathway. In addition, plakoglobin is also found in desmosomes, a vertebrate-specific cell–cell adhesion structure...