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Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
..., kinases and β-arrestins) and on the dynamics of the interconversion among all these states. To improve on this will require collaborations between biophysicists and molecular modellers, as well as biochemists and pharmacologists, to use existing techniques and develop new tools to solve the problems...
Biochem Soc Trans (2013) 41 (1): 231–236.
Published: 29 January 2013
... are supported by G-protein-independent, β-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous β-arrestin-biased signalling receptors...
Biochem Soc Trans (2007) 35 (5): 938–941.
Published: 25 October 2007
... in catalytic function, each isoform appears to serve a non-superfluous regulatory role. For example, a β-arrestin-sequestered subpopulation of the PDE4D5 isoform specifically regulates the phosphorylation of the β 2 -AR (β 2 -adrenergic receptor) by PKA (protein kinase A; also called cAMP-dependent protein...
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
...K.D.G. Pfleger; M.B. Dalrymple; J.R. Dromey; K.A. Eidne β-Arrestins 1 and 2 are ubiquitously expressed intracellular adaptor and scaffolding proteins that play important roles in GPCR (G-protein-coupled receptor) desensitization, internalization, intracellular trafficking and G-protein-independent...
Biochem Soc Trans (2006) 34 (4): 474–475.
Published: 21 July 2006
... intracellular locations or signalling complexes. A novel facet of PDE4 function was uncovered when it was discovered that PDE4s, and PDE4D5 in particular, could bind to and translocate with the multi-functional scaffold protein β-arrestin [ 3 , 4 ]. The primary function of β-arrestins is to desensitize...
Biochem Soc Trans (2005) 33 (6): 1333–1336.
Published: 26 October 2005
... isoform preferentially interacts with the signalling scaffold protein β-arrestin and is thereby recruited to the β 2 -AR upon agonist challenge. Delivery of an active PDE to the site of cAMP synthesis at the plasma membrane specifically attenuates the activity of a pool of PKA (protein kinase...
Biochem Soc Trans (2003) 31 (6): 1191–1197.
Published: 01 December 2003
... is attenuated by β-arrestin-mediated desensitization and endocytosis, and by lysosomal targeting and degradation, which requires ubiquitination of PAR 2 . β-Arrestins also act as scaffolds for the assembly of multi-protein signalling complexes that determine the location and function of activated mitogen...
Biochem Soc Trans (2001) 29 (4): 505–508.
Published: 01 August 2001
... acetylcholine receptors (mAChRs). Using the transient expression system of HEK-293 cells, we showed that the M 1 , M 3 and M 4 mAChRs are internalized into clathrin-coated vesicles and recycle back to the plasma membrane. This internalization pathway is dependent on the concerted action of β-arrestin, c-Src...