... features including the involvement of mitochondria in the mechanism of pathology and misfolding and the accumulation of abnormally aggregated proteins. Neurotoxicity of aggregated β-amyloid, tau, α-synuclein and huntingtin is linked to the effects of these proteins on mitochondria. All these misfolded...

... and twisted filaments from short tau peptides J. Biol. Chem. 2004 279 26868 26875 6 Balbach J.J. Ishii Y. Antzutkin O.N. Leapman R.D. Rizzo N.W. Dyda F. Reed J. Tycko R. Amyloid fibril formation by Aβ16–22, a seven-residue fragment of the Alzheimer's β-amyloid...

.... A high-cholesterol diet improves spatial memory in experimental animals. β-Amyloid, the toxic peptide in neurons of AD (Alzheimer's disease) patients, binds cholesterol and catalyses its oxidation to 7β-hydroxycholesterol, a highly toxic oxysterol that is a potent inhibitor of α-PKC (α-protein kinase C...

...G. Gibson; O.M.A. El-Agnaf; Z. Anwar; C. Sidera; A. Isbister; B.M. Austen A number of human neurodegenerative diseases involve aggregated amyloid proteins in the brain, e.g. Alzheimer's disease (β-amyloid) and Parkinson's disease (α-synuclein). Other examples are rare familial dementias which...