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Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 613–618.
Published: 22 July 2008
... and clinical settings. Transcriptional regulation, the ability to turn genes on and off, lies at the heart of these processes of lineage commitment and specification. We have focused on fully understanding how these decisions are made at a single mammalian gene locus, the α-globin genes, which become up...