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Articles

The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches

Emily Gruber, Lev M. Kats
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1675–1686.
https://doi.org/10.1042/BST20230017
Published: 01 August 2023
View article titled, The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
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Articles

Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

Uzma Jaffry, Geoff Wells
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 925–936.
https://doi.org/10.1042/BST20220352
Published: 09 June 2023
View article titled, Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction
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Articles

Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence

In Collection
Coronavirus
Xiyuan Bai, Tony Schountz, Ashley M. Buckle, Janet L. Talbert, Robert A. Sandhaus, Edward D. Chan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1361–1375.
https://doi.org/10.1042/BST20230078
Published: 09 June 2023
View article titled, Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence
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Articles

Exploring microRNAs in craniofacial regenerative medicine

Dan Su, Samuel Swearson, Tadkamol Krongbaramee, Hongli Sun, Liu Hong, Brad A. Amendt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 841–854.
https://doi.org/10.1042/BST20221448
Published: 19 April 2023
View article titled, Exploring microRNAs in craniofacial regenerative medicine
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Articles

CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy

Mario K. Shammas, Tzu-Hsiang Huang, Derek P. Narendra
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 797–809.
https://doi.org/10.1042/BST20221365
Published: 06 April 2023
View article titled, CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy
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Articles

The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders

Nicole E. Chambers, Michael Millett, Jr, Mark S. Moehle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 691–702.
https://doi.org/10.1042/BST20220525
Published: 04 April 2023
View article titled, The muscarinic M 4 acetylcholine receptor exacerbates symptoms of movement disorders
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Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Safak Er, Mikko Airavaara
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 245–257.
https://doi.org/10.1042/BST20220770
Published: 16 February 2023
View article titled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease
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Articles

Targeting NRF2 to promote epithelial repair

Paul Hiebert, Sabine Werner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 101–111.
https://doi.org/10.1042/BST20220228
Published: 10 February 2023
View article titled, Targeting NRF2 to promote epithelial repair
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Articles

A multi-dimensional view of context-dependent G protein-coupled receptor function

In Collection
Awards
Maria Marti-Solano
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 13–20.
https://doi.org/10.1042/BST20210650
Published: 23 January 2023
View article titled, A multi-dimensional view of context-dependent G protein-coupled receptor function
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Articles

Structural analysis of mycobacterial electron transport chain complexes by cryoEM

Yingke Liang, John L. Rubinstein
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
https://doi.org/10.1042/BST20220611
Published: 20 January 2023
View article titled, Structural analysis of mycobacterial electron transport chain complexes by cryoEM
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Articles

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E

Jerry Pelletier, Nahum Sonenberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 113–124.
https://doi.org/10.1042/BST20220285
Published: 20 January 2023
View article titled, Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
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Articles

Therapeutic targeting of TRAIL death receptors

In Collection
Cell death and survival
Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 57–70.
https://doi.org/10.1042/BST20220098
Published: 11 January 2023
View article titled, Therapeutic targeting of TRAIL death receptors
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Articles

Targeting the DNA damage response for cancer therapy

In Collection
Awards
Nicola J. Curtin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 207–221.
https://doi.org/10.1042/BST20220681
Published: 06 January 2023
View article titled, Targeting the DNA damage response for cancer therapy
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Articles

How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes

Shirin Hosseini, Martin Korte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 259–274.
https://doi.org/10.1042/BST20220771
Published: 06 January 2023
View article titled, How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes
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Articles

Exploring craniofacial and dental development with microRNAs

Dan Su, Tadkamol Krongbaramee, Hongli Sun, Liu Hong, Brad A. Amendt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1897–1909.
https://doi.org/10.1042/BST20221042
Published: 09 December 2022
View article titled, Exploring craniofacial and dental development with microRNAs
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Articles

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Sharissa L. Latham, Yolande E.I. O'Donnell, David R. Croucher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1823–1836.
https://doi.org/10.1042/BST20220808
Published: 01 December 2022
View article titled, Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
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Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Heather M. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
https://doi.org/10.1042/BST20220441
Published: 23 November 2022
View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
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Articles

The role of sensory kinase proteins in two-component signal transduction

Adrián F. Alvarez, Dimitris Georgellis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1859–1873.
https://doi.org/10.1042/BST20220848
Published: 18 November 2022
View article titled, The role of sensory kinase proteins in two-component signal transduction
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Articles

Cancer cells hijack RNA processing to rewrite the message

Katherine L.B. Borden
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1447–1456.
https://doi.org/10.1042/BST20220621
Published: 25 October 2022
View article titled, Cancer cells hijack RNA processing to rewrite the message
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Articles

The role of autophagy-lysosomal pathway in motor neuron diseases

Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1489–1503.
https://doi.org/10.1042/BST20220778
Published: 16 September 2022
View article titled, The role of autophagy-lysosomal pathway in motor neuron diseases
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Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1377–1388.
https://doi.org/10.1042/BST20220446
Published: 06 September 2022
View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury
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Articles

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging

Hanwen Zhang, Xiaohui Lin, Shan Zha
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1169–1177.
https://doi.org/10.1042/BST20220366
Published: 12 August 2022
View article titled, Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging
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Articles

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

Kendelle J. Murphy, Jessie Zhu, Michael Trpceski, Brooke A. Pereira, Paul Timpson, David Herrmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1129–1141.
https://doi.org/10.1042/BST20220162
Published: 05 August 2022
View article titled, Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy
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Articles

Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Gaoyuan Wang, Sarah T. Diepstraten, Marco J. Herold
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1119–1128.
https://doi.org/10.1042/BST20220153
Published: 28 July 2022
View article titled, Last but not least: BFL-1 as an emerging target for anti-cancer therapies
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Articles

Three-dimensional models of the lung: past, present and future: a mini review

Chandani Sen, Delilah Freund, Brigitte N. Gomperts
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 1045–1056.
https://doi.org/10.1042/BST20190569
Published: 11 April 2022
View article titled, Three-dimensional models of the lung: past, present and future: a mini review
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Articles

Daylight-PDT: everything under the sun

Dana Beiki, Ian M. Eggleston, Charareh Pourzand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 975–985.
https://doi.org/10.1042/BST20200822
Published: 06 April 2022
View article titled, Daylight-PDT: everything under the sun
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Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Steven R. Van Doren
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 839–851.
https://doi.org/10.1042/BST20210640
Published: 28 March 2022
View article titled, MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains
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Articles

Therapeutic targeting of mitophagy in Parkinson's disease

In Collection
Cell death and survival
Shashank Masaldan, Sylvie Callegari, Grant Dewson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 783–797.
https://doi.org/10.1042/BST20211107
Published: 21 March 2022
View article titled, Therapeutic targeting of mitophagy in Parkinson's disease
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Articles

Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Rita Alonaizan, Carolyn Carr
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 269–281.
https://doi.org/10.1042/BST20210231
Published: 07 February 2022
View article titled, Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation
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Articles

The molecular pathogenesis of repeat expansion diseases

Yuzo Fujino, Yoshitaka Nagai
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 119–134.
https://doi.org/10.1042/BST20200143
Published: 23 December 2021
View article titled, The molecular pathogenesis of repeat expansion diseases
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Articles

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

Kensaku Murano, Youjia Guo, Haruhiko Siomi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2879–2890.
https://doi.org/10.1042/BST20210859
Published: 02 December 2021
View article titled, The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines
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Articles

Isocitrate dehydrogenase gene variants in cancer and their clinical significance

Thomas Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2561–2572.
https://doi.org/10.1042/BST20210277
Published: 02 December 2021
View article titled, Isocitrate dehydrogenase gene variants in cancer and their clinical significance
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Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2253–2269.
https://doi.org/10.1042/BST20210343
Published: 28 October 2021
View article titled, Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
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Articles

LUBAC: a new player in polyglucosan body disease

Andrew Aboujaoude, Berge Minassian, Sharmistha Mitra
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2443–2454.
https://doi.org/10.1042/BST20210838
Published: 28 October 2021
View article titled, LUBAC: a new player in polyglucosan body disease
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Articles

Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer

Marie Sorbara, Nicolas Bery
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2021–2035.
https://doi.org/10.1042/BST20201059
Published: 08 October 2021
View article titled, Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer
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Articles

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

In Collection
Cell death and survival
W. Douglas Fairlie, Erinna F. Lee
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2397–2410.
https://doi.org/10.1042/BST20210750
Published: 28 September 2021
View article titled, Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers
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Articles

Type 2 immunity in intestinal homeostasis and inflammatory bowel disease

Xinxin Luo, Eduardo J. Villablanca
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2371–2380.
https://doi.org/10.1042/BST20210535
Published: 28 September 2021
View article titled, Type 2 immunity in intestinal homeostasis and inflammatory bowel disease
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Articles

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

In Collection
Cell death and survival
Erinna F. Lee, W. Douglas Fairlie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2381–2395.
https://doi.org/10.1042/BST20210749
Published: 13 September 2021
View article titled, Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
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Articles

Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments

Magdalena E. Zasłona, A. Michael Downey, Peter H. Seeberger, Oren Moscovitz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2411–2429.
https://doi.org/10.1042/BST20210766
Published: 08 September 2021
View article titled, Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments
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Articles

The role of pro-domains in human growth factors and cytokines

Matthew Ratcliff, Richard Xu Zhou, Lutz Jermutus, Marko Hyvönen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 1963–1973.
https://doi.org/10.1042/BST20200663
Published: 08 September 2021
View article titled, The role of pro-domains in human growth factors and cytokines
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Articles

Modulating cell differentiation in cancer models

Paola Fulghieri, Lucia Anna Stivala, Virginie Sottile
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1803–1816.
https://doi.org/10.1042/BST20210230
Published: 26 August 2021
View article titled, Modulating cell differentiation in cancer models
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Articles

The influence of lipid digestion on the fate of orally administered drug delivery vehicles

Ben J. Boyd, Andrew J. Clulow
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1749–1761.
https://doi.org/10.1042/BST20210168
Published: 25 August 2021
View article titled, The influence of lipid digestion on the fate of orally administered drug delivery vehicles
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Articles

Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

Aaron D. Krabill, Zhong-Yin Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1723–1734.
https://doi.org/10.1042/BST20201308
Published: 25 August 2021
View article titled, Functional interrogation and therapeutic targeting of protein tyrosine phosphatases
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Articles

The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities

Julia Varga, Marie Kube, Katja Luck, Sandra Schick
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1489–1503.
https://doi.org/10.1042/BST20190960
Published: 25 August 2021
View article titled, The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities
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Includes: Supplementary data
Articles

Plant derived cyclic peptides

Norelle L. Daly, David T. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1279–1285.
https://doi.org/10.1042/BST20200881
Published: 22 June 2021
View article titled, Plant derived cyclic peptides
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Articles

Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

Johann Matschke, Safa Larafa, Verena Jendrossek
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1265–1277.
https://doi.org/10.1042/BST20200866
Published: 10 June 2021
View article titled, Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?
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Articles

Progress in the therapeutic inhibition of Cdc42 signalling

Natasha P. Murphy, Helen R. Mott, Darerca Owen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1443–1456.
https://doi.org/10.1042/BST20210112
Published: 08 June 2021
View article titled, Progress in the therapeutic inhibition of Cdc42 signalling
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Articles

Heterochromatin and Polycomb as regulators of haematopoiesis

Christine R. Keenan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 805–814.
https://doi.org/10.1042/BST20200737
Published: 30 April 2021
View article titled, Heterochromatin and Polycomb as regulators of haematopoiesis
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Articles

Serpins in cartilage and osteoarthritis: what do we know?

David J. Wilkinson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 1013–1026.
https://doi.org/10.1042/BST20201231
Published: 12 April 2021
View article titled, Serpins in cartilage and osteoarthritis: what do we know?
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Articles

Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders

Lydia M. Castelli, Wan-Ping Huang, Ya-Hui Lin, Kung-Yao Chang, Guillaume M. Hautbergue
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 775–792.
https://doi.org/10.1042/BST20200690
Published: 17 March 2021
View article titled, Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders
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