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Articles

Fast-forward on P-type ATPases: recent advances on structure and function

Charlott Stock, Tomáš Heger, Sara Basse Hansen, Sigrid Thirup Larsen, Michael Habeck, Thibaud Dieudonné, Ronja Driller, Poul Nissen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221543.
DOI: https://doi.org/10.1042/BST20221543
Published: 02 June 2023
View article titled, Fast-forward on P-type ATPases: recent advances on structure and function
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Articles

Cytoophidia and filaments: you must unlearn what you have learned

Chen-Jun Guo, Ji-Long Liu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221410.
DOI: https://doi.org/10.1042/BST20221410
Published: 30 May 2023
View article titled, Cytoophidia and filaments: you must unlearn what you have learned
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Articles

The Nrd1–Nab3–Sen1 transcription termination complex from a structural perspective

Belén Chaves-Arquero, José Manuel Pérez-Cañadillas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221418.
DOI: https://doi.org/10.1042/BST20221418
Published: 24 May 2023
View article titled, The Nrd1–Nab3–Sen1 transcription termination complex from a structural perspective
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Articles

Recent insights into mechanisms of cellular toxicity and cell recognition associated with the ABC family of pore-forming toxins

Nadezhda A. Aleksandrova, Solace G. Roche, Yu Shang Low, Michael J. Landsberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221409.
DOI: https://doi.org/10.1042/BST20221409
Published: 18 May 2023
View article titled, Recent insights into mechanisms of cellular toxicity and cell recognition associated with the ABC family of pore-forming toxins
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Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221400.
DOI: https://doi.org/10.1042/BST20221400
Published: 04 May 2023
View article titled, The molecular mechanisms of human separase regulation
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Articles

The molecular mechanisms of the bacterial iron sensor IdeR

Francisco Javier Marcos-Torres, Linda Juniar, Julia J. Griese
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221539.
DOI: https://doi.org/10.1042/BST20221539
Published: 04 May 2023
View article titled, The molecular mechanisms of the bacterial iron sensor IdeR
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Articles

Improving the hole picture: towards a consensus on the mechanism of nuclear transport

David Cowburn, Michael Rout
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 871–886.
DOI: https://doi.org/10.1042/BST20220494
Published: 26 April 2023
View article titled, Improving the hole picture: towards a consensus on the mechanism of nuclear transport
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Articles

The building blocks of caveolae revealed: caveolins finally take center stage

Anne K. Kenworthy
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 855–869.
DOI: https://doi.org/10.1042/BST20221298
Published: 21 April 2023
View article titled, The building blocks of caveolae revealed: caveolins finally take center stage
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Articles

Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling

Melissa J.S. MacEwen, Yasemin Sancak
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 665–673.
DOI: https://doi.org/10.1042/BST20220317
Published: 24 March 2023
View article titled, Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling
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Articles

Mre11–Rad50: the DNA end game

Karl-Peter Hopfner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 527–538.
DOI: https://doi.org/10.1042/BST20220754
Published: 09 March 2023
View article titled, Mre11–Rad50: the DNA end game
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Articles

Allosteric regulation and inhibition of protein kinases

Victoria R. Mingione, YiTing Paung, Ian R. Outhwaite, Markus A. Seeliger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 373–385.
DOI: https://doi.org/10.1042/BST20220940
Published: 16 February 2023
View article titled, Allosteric regulation and inhibition of protein kinases
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Articles

Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM

Florian Fäßler, Manjunath G. Javoor, Florian KM Schur
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 87–99.
DOI: https://doi.org/10.1042/BST20220221
Published: 25 January 2023
View article titled, Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM
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Articles

Structural insights on the KMT2–NCP interaction

Zi Yang, Robert Zepeda, Yali Dou
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 427–434.
DOI: https://doi.org/10.1042/BST20221155
Published: 25 January 2023
View article titled, Structural insights on the KMT2–NCP interaction
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Articles

Structural analysis of mycobacterial electron transport chain complexes by cryoEM

Yingke Liang, John L. Rubinstein
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
DOI: https://doi.org/10.1042/BST20220611
Published: 20 January 2023
View article titled, Structural analysis of mycobacterial electron transport chain complexes by cryoEM
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Articles

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

Katerina Cermakova, Vaclav Veverka, H. Courtney Hodges
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 125–135.
DOI: https://doi.org/10.1042/BST20220342
Published: 18 January 2023
View article titled, The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder
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Articles

Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology

Steven Turner, Jonathan W. Essex, Tim Elliott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 275–285.
DOI: https://doi.org/10.1042/BST20220782
Published: 16 January 2023
View article titled, Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology
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Articles

From seeds to trees: how E2 enzymes grow ubiquitin chains

Adam J. Middleton, Catherine L. Day
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 353–362.
DOI: https://doi.org/10.1042/BST20220880
Published: 16 January 2023
View article titled, From seeds to trees: how E2 enzymes grow ubiquitin chains
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Articles

Interactions governing transcriptional activity of nuclear receptors

Sabab Hasan Khan, C. Denise Okafor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1941–1952.
DOI: https://doi.org/10.1042/BST20220338
Published: 16 December 2022
View article titled, Interactions governing transcriptional activity of nuclear receptors
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Articles

Lumenal components of cytoplasmic microtubules

Chisato Tsuji, Mark P. Dodding
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1953–1962.
DOI: https://doi.org/10.1042/BST20220851
Published: 16 December 2022
View article titled, Lumenal components of cytoplasmic microtubules
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Articles

Deciphering the mechanism and function of Hsp100 unfoldases from protein structure

Grace Lee, Rebecca S. Kim, Sang Bum Lee, Sukyeong Lee, Francis T.F. Tsai
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1725–1736.
DOI: https://doi.org/10.1042/BST20220590
Published: 01 December 2022
View article titled, Deciphering the mechanism and function of Hsp100 unfoldases from protein structure
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Articles

Investigating how intrinsically disordered regions contribute to protein function using HDX-MS

Matthew A.H. Parson, Meredith L. Jenkins, John E. Burke
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1607–1617.
DOI: https://doi.org/10.1042/BST20220206
Published: 01 December 2022
View article titled, Investigating how intrinsically disordered regions contribute to protein function using HDX-MS
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Articles

Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches

Kyprianos Hadjidemetriou, Satinder Kaur, C. Keith Cassidy, Peijun Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1595–1605.
DOI: https://doi.org/10.1042/BST20220191
Published: 24 November 2022
View article titled, Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches
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Articles

Structure and function of the peroxisomal ubiquitin ligase complex

Peiqiang Feng, Michael L. Skowyra, Tom A. Rapoport
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1921–1930.
DOI: https://doi.org/10.1042/BST20221393
Published: 24 November 2022
View article titled, Structure and function of the peroxisomal ubiquitin ligase complex
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Articles

Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt

Neha Mani, Rie Nygaard, Filippo Mancia
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1763–1772.
DOI: https://doi.org/10.1042/BST20220634
Published: 23 November 2022
View article titled, Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt
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Articles

The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI

Dmitry Lyumkis, Nancy C. Horton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1703–1714.
DOI: https://doi.org/10.1042/BST20220547
Published: 18 November 2022
View article titled, The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
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Articles

The role of sensory kinase proteins in two-component signal transduction

Adrián F. Alvarez, Dimitris Georgellis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1859–1873.
DOI: https://doi.org/10.1042/BST20220848
Published: 18 November 2022
View article titled, The role of sensory kinase proteins in two-component signal transduction
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Articles

Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation

Benjamin Rowlinson, Elodie Crublet, Rime Kerfah, Michael J. Plevin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1555–1567.
DOI: https://doi.org/10.1042/BST20210586
Published: 16 November 2022
View article titled, Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation
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Articles

Characterising ion channel structure and dynamics using fluorescence spectroscopy techniques

Shreyas Bhat, Rikard Blunck
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1427–1445.
DOI: https://doi.org/10.1042/BST20220605
Published: 25 October 2022
View article titled, Characterising ion channel structure and dynamics using fluorescence spectroscopy techniques
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Articles

The long and the short of Periscope Proteins

Fiona Whelan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1293–1302.
DOI: https://doi.org/10.1042/BST20220194
Published: 05 October 2022
View article titled, The long and the short of Periscope Proteins
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Articles

Mechanistic insights into protein folding by the eukaryotic chaperonin complex CCT

Theresa M. Smith, Barry M. Willardson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1403–1414.
DOI: https://doi.org/10.1042/BST20220591
Published: 05 October 2022
View article titled, Mechanistic insights into protein folding by the eukaryotic chaperonin complex CCT
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Articles

Protective HLA-B57: T cell and natural killer cell recognition in HIV infection

Christian A. Lobos, Jonathan Downing, Lloyd J. D'Orsogna, Demetra S.M. Chatzileontiadou, Stephanie Gras
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1329–1339.
DOI: https://doi.org/10.1042/BST20220244
Published: 16 September 2022
View article titled, Protective HLA-B57: T cell and natural killer cell recognition in HIV infection
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Articles

LILBID-MS: using lasers to shed light on biomolecular architectures

Nils Hellwig, Janosch Martin, Nina Morgner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1057–1067.
DOI: https://doi.org/10.1042/BST20190881
Published: 13 June 2022
View article titled, LILBID-MS: using lasers to shed light on biomolecular architectures
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Articles

Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants

Abi S. Ghifari, Monika W. Murcha
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1119–1132.
DOI: https://doi.org/10.1042/BST20220195
Published: 19 May 2022
View article titled, Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants
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Articles

Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy

Wei-Chun Kao, Carola Hunte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 877–893.
DOI: https://doi.org/10.1042/BST20190963
Published: 31 March 2022
View article titled, Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy
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Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Steven R. Van Doren
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 839–851.
DOI: https://doi.org/10.1042/BST20210640
Published: 28 March 2022
View article titled, MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains
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Articles

Drug repurposing in silico screening platforms

Jonathan G.L. Mullins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 747–758.
DOI: https://doi.org/10.1042/BST20200967
Published: 14 March 2022
View article titled, Drug repurposing in silico screening platforms
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Articles

Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?

Ekaterina Shevchenko, Tatu Pantsar
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 633–648.
DOI: https://doi.org/10.1042/BST20210837
Published: 28 February 2022
View article titled, Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?
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Articles

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

In Collection
Awards
Valerie B. O'Donnell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 1–11.
DOI: https://doi.org/10.1042/BST20210579
Published: 28 February 2022
View article titled, New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
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Articles

Exploring cryo-electron microscopy with molecular dynamics

John W. Vant, Daipayan Sarkar, Jonathan Nguyen, Alexander T. Baker, Josh V. Vermaas, Abhishek Singharoy
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 569–581.
DOI: https://doi.org/10.1042/BST20210485
Published: 25 February 2022
View article titled, Exploring cryo-electron microscopy with molecular dynamics
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Articles

IMPDH dysregulation in disease: a mini review

Anika L. Burrell, Justin M. Kollman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 71–82.
DOI: https://doi.org/10.1042/BST20210446
Published: 22 February 2022
View article titled, IMPDH dysregulation in disease: a mini review
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Articles

Studying membrane proteins with MicroED

Marc J. Gallenito, Tamir Gonen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 231–239.
DOI: https://doi.org/10.1042/BST20210911
Published: 22 February 2022
View article titled, Studying membrane proteins with MicroED
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Articles

Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins

F. Emil Thomasen, Kresten Lindorff-Larsen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 541–554.
DOI: https://doi.org/10.1042/BST20210499
Published: 07 February 2022
View article titled, Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
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Articles

Multiple roles of Pol epsilon in eukaryotic chromosome replication

Milos A. Cvetkovic, Esther Ortega, Roberto Bellelli, Alessandro Costa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 309–320.
DOI: https://doi.org/10.1042/BST20210082
Published: 07 February 2022
View article titled, Multiple roles of Pol epsilon in eukaryotic chromosome replication
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Articles

Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits

Joshua M. Hardy, Rhys A. Dunstan, Trevor Lithgow, Fasséli Coulibaly
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 459–22W.
DOI: https://doi.org/10.1042/BST20210799
Published: 07 February 2022
View article titled, Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits
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Articles

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza, Alexandra M. Blee, Walter J. Chazin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 375–386.
DOI: https://doi.org/10.1042/BST20210246
Published: 25 January 2022
View article titled, Mechanism of action of nucleotide excision repair machinery
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Articles

Three-dimensional insights into human enveloped viruses in vitro and in situ

Naveen Vankadari, Doulin C. Shepherd, Stephen D. Carter, Debnath Ghosal
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 95–105.
DOI: https://doi.org/10.1042/BST20210433
Published: 25 January 2022
View article titled, Three-dimensional insights into human enveloped viruses in vitro and in situ
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Articles

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

Matthew J. A. Hein, Marc Kvansakul, Fung T. Lay, Thanh Kha Phan, Mark D. Hulett
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 423–437.
DOI: https://doi.org/10.1042/BST20200884
Published: 11 January 2022
View article titled, Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
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Articles

Tyrosine- O -sulfation is a widespread affinity enhancer among thrombin interactors

Jorge Ripoll-Rozada, Joshua W. C. Maxwell, Richard J. Payne, Pedro José Barbosa Pereira
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 387–401.
DOI: https://doi.org/10.1042/BST20210600
Published: 07 January 2022
View article titled, Tyrosine- O -sulfation is a widespread affinity enhancer among thrombin interactors
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Articles

VDAC2 and the BCL-2 family of proteins

In Collection
Cell death and survival
Zheng Yuan, Grant Dewson, Peter E. Czabotar, Richard W. Birkinshaw
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2787–2795.
DOI: https://doi.org/10.1042/BST20210753
Published: 16 December 2021
View article titled, VDAC2 and the BCL-2 family of proteins
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Articles

Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria

Benjamin A. Ford, Geraldine J. Sullivan, Lisa Moore, Deepa Varkey, Hannah Zhu, Martin Ostrowski, Bridget C. Mabbutt, Ian T. Paulsen, Bhumika S. Shah
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2465–2481.
DOI: https://doi.org/10.1042/BST20200244
Published: 09 December 2021
View article titled, Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria
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Includes: Supplementary data