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Articles

Caveolae and the oxidative stress response

Yeping Wu, Ye-Wheen Lim, Robert G. Parton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230121.
DOI: https://doi.org/10.1042/BST20230121
Published: 30 May 2023
View article titled, Caveolae and the oxidative stress response
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Articles

Insulin signalling and GLUT4 trafficking in insulin resistance

Julian van Gerwen, Amber S. Shun-Shion, Daniel J. Fazakerley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221066.
DOI: https://doi.org/10.1042/BST20221066
Published: 30 May 2023
View article titled, Insulin signalling and GLUT4 trafficking in insulin resistance
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Articles

The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis

Fabian Gude, Jurij Froese, Georg Steffes, Kay Grobe
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220719.
DOI: https://doi.org/10.1042/BST20220719
Published: 24 May 2023
View article titled, The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis
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Articles

Differential functions of the KRAS splice variants

Juan Kochen Rossi, Cristina Nuevo-Tapioles, Mark R. Philips
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221347.
DOI: https://doi.org/10.1042/BST20221347
Published: 24 May 2023
View article titled, Differential functions of the KRAS splice variants
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Articles

Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction

Shanelle De Silva, Zhijuan Fan, Baoqiang Kang, Catherine M. Shanahan, Qiuping Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221541.
DOI: https://doi.org/10.1042/BST20221541
Published: 12 May 2023
View article titled, Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction
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Articles

The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism

Qiang Zhang, Bin Tian
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221128.
DOI: https://doi.org/10.1042/BST20221128
Published: 12 May 2023
View article titled, The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism
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Articles

Messenger functions of cell death during development and homeostasis

Loic Fort
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 759–769.
DOI: https://doi.org/10.1042/BST20220925
Published: 06 April 2023
View article titled, Messenger functions of cell death during development and homeostasis
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Articles

Extracellular vesicles in carcinoma microenvironment

Larissa Tinô de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sá, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 771–781.
DOI: https://doi.org/10.1042/BST20221175
Published: 06 April 2023
View article titled, Extracellular vesicles in carcinoma microenvironment
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Articles

Effectors and effects of arginine methylation

Yalong Wang, Mark T. Bedford
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 725–734.
DOI: https://doi.org/10.1042/BST20221147
Published: 04 April 2023
View article titled, Effectors and effects of arginine methylation
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Articles

Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling

Melissa J.S. MacEwen, Yasemin Sancak
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 665–673.
DOI: https://doi.org/10.1042/BST20220317
Published: 24 March 2023
View article titled, Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling
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Articles

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

Rachel Fasiczka, Yahaira Naaldijk, Besma Brahmia, Sabine Hilfiker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 587–595.
DOI: https://doi.org/10.1042/BST20201145
Published: 17 March 2023
View article titled, Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation
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Articles

Regulation of mTORC1 by the Rag GTPases

Tshering D. Lama-Sherpa, Mi-Hyeon Jeong, Jenna L. Jewell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 655–664.
DOI: https://doi.org/10.1042/BST20210038
Published: 16 March 2023
View article titled, Regulation of mTORC1 by the Rag GTPases
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Articles

Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling

Tahir Muhammad, Jian Li
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 501–512.
DOI: https://doi.org/10.1042/BST20220616
Published: 09 March 2023
View article titled, Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling
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Articles

New discoveries in ER–mitochondria communication

Margret Helene Bülow, Julia Sellin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 571–577.
DOI: https://doi.org/10.1042/BST20221305
Published: 09 March 2023
View article titled, New discoveries in ER–mitochondria communication
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Articles

Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?

Syeda Farhana Afroz, Karoline D. Raven, Grace M.E.P. Lawrence, Ronan Kapetanovic, Kate Schroder, Matthew J. Sweet
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 41–56.
DOI: https://doi.org/10.1042/BST20220014
Published: 23 February 2023
View article titled, Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?
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Articles

A multi-dimensional view of context-dependent G protein-coupled receptor function

In Collection
Awards
Maria Marti-Solano
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 13–20.
DOI: https://doi.org/10.1042/BST20210650
Published: 23 January 2023
View article titled, A multi-dimensional view of context-dependent G protein-coupled receptor function
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Articles

The role of post-translational modifications in synaptic AMPA receptor activity

Elisa Corti, Carlos B. Duarte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 315–330.
DOI: https://doi.org/10.1042/BST20220827
Published: 11 January 2023
View article titled, The role of post-translational modifications in synaptic AMPA receptor activity
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Articles

Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance

João M. N. Duarte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 287–301.
DOI: https://doi.org/10.1042/BST20220789
Published: 06 January 2023
View article titled, Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance
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Articles

The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer

Aristeidis Panagiotis Sfakianos, Rebecca Mallory Raven, Anne Elizabeth Willis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1885–1895.
DOI: https://doi.org/10.1042/BST20221035
Published: 13 December 2022
View article titled, The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer
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Articles

Functional regulation of Wnt protein through post-translational modifications

Jia Yu, David M. Virshup
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1797–1808.
DOI: https://doi.org/10.1042/BST20220735
Published: 09 December 2022
View article titled, Functional regulation of Wnt protein through post-translational modifications
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Articles

Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation

Noah S. Helton, Stephanie L. Moon
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1715–1724.
DOI: https://doi.org/10.1042/BST20220549
Published: 09 December 2022
View article titled, Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation
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Articles

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Sharissa L. Latham, Yolande E.I. O'Donnell, David R. Croucher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1823–1836.
DOI: https://doi.org/10.1042/BST20220808
Published: 01 December 2022
View article titled, Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
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Articles

Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches

Kyprianos Hadjidemetriou, Satinder Kaur, C. Keith Cassidy, Peijun Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1595–1605.
DOI: https://doi.org/10.1042/BST20220191
Published: 24 November 2022
View article titled, Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches
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Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Heather M. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
DOI: https://doi.org/10.1042/BST20220441
Published: 23 November 2022
View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
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Articles

Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation

Nazmus Salehin, Hilary Knowles, V. Pragathi Masamsetti, Patrick P.L. Tam
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1619–1631.
DOI: https://doi.org/10.1042/BST20220256
Published: 18 November 2022
View article titled, Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation
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Articles

The role of sensory kinase proteins in two-component signal transduction

Adrián F. Alvarez, Dimitris Georgellis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1859–1873.
DOI: https://doi.org/10.1042/BST20220848
Published: 18 November 2022
View article titled, The role of sensory kinase proteins in two-component signal transduction
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Articles

ERK1/2 in immune signalling

Richard M. Lucas, Lin Luo, Jennifer L. Stow
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1341–1352.
DOI: https://doi.org/10.1042/BST20220271
Published: 25 October 2022
View article titled, ERK1/2 in immune signalling
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Articles

Dynamics of phagocytosis mediated by phosphatidylserine

Daan Vorselen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1281–1291.
DOI: https://doi.org/10.1042/BST20211254
Published: 25 October 2022
View article titled, Dynamics of phagocytosis mediated by phosphatidylserine
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Articles

The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors

Jurre A. Steens, Carl Raymund P. Salazar, Raymond H.J. Staals
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1353–1364.
DOI: https://doi.org/10.1042/BST20220289
Published: 25 October 2022
View article titled, The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors
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Articles

The functional importance of VCP to maintaining cellular protein homeostasis

Brittany A. Ahlstedt, Rakesh Ganji, Malavika Raman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1457–1469.
DOI: https://doi.org/10.1042/BST20220648
Published: 05 October 2022
View article titled, The functional importance of VCP to maintaining cellular protein homeostasis
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Articles

Regulation of ATR–CHK1 signaling by ubiquitination of CLASPIN

Xuefei Zhu, Xiang-Yang Zheng, Peng Gong, Xingzhi Xu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1471–1480.
DOI: https://doi.org/10.1042/BST20220729
Published: 05 October 2022
View article titled, Regulation of ATR–CHK1 signaling by ubiquitination of CLASPIN
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Articles

The role of RHIM in necroptosis

In Collection
Cell death and survival
Theresa Riebeling, Ulrich Kunzendorf, Stefan Krautwald
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1197–1205.
DOI: https://doi.org/10.1042/BST20220535
Published: 30 August 2022
View article titled, The role of RHIM in necroptosis
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Articles

CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development

Nicole J. Van Bergen, Sean Massey, Anita Quigley, Ben Rollo, Alexander R. Harris, Robert M.I. Kapsa, John Christodoulou
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1207–1224.
DOI: https://doi.org/10.1042/BST20220791
Published: 23 August 2022
View article titled, CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development
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Articles

Two-pore channels: going with the flows

Anthony J. Morgan, Lora L. Martucci, Lianne C. Davis, Antony Galione
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1143–1155.
DOI: https://doi.org/10.1042/BST20220229
Published: 12 August 2022
View article titled, Two-pore channels: going with the flows
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Articles

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

Kendelle J. Murphy, Jessie Zhu, Michael Trpceski, Brooke A. Pereira, Paul Timpson, David Herrmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1129–1141.
DOI: https://doi.org/10.1042/BST20220162
Published: 05 August 2022
View article titled, Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy
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Articles

The intersection between circadian and heat-responsive regulatory networks controls plant responses to increasing temperatures

Kanjana Laosuntisuk, Colleen J. Doherty
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1151–1165.
DOI: https://doi.org/10.1042/BST20190572
Published: 27 June 2022
View article titled, The intersection between circadian and heat-responsive regulatory networks controls plant responses to increasing temperatures
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Articles

The evolution and structure/function of bHLH–PAS transcription factor family

Hailey E. Edwards, Daniel A. Gorelick
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1227–1243.
DOI: https://doi.org/10.1042/BST20211225
Published: 13 June 2022
View article titled, The evolution and structure/function of bHLH–PAS transcription factor family
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Articles

Functional diversity in the RAS subfamily of small GTPases

Gabriela Bernal Astrain, Maya Nikolova, Matthew J. Smith
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 921–933.
DOI: https://doi.org/10.1042/BST20211166
Published: 31 March 2022
View article titled, Functional diversity in the RAS subfamily of small GTPases
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Articles

Understanding immune signaling using advanced imaging techniques

Mario Brameshuber, Enrico Klotzsch, Aleks Ponjavic, Erdinc Sezgin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 853–866.
DOI: https://doi.org/10.1042/BST20210479
Published: 28 March 2022
View article titled, Understanding immune signaling using advanced imaging techniques
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Articles

PIDD1 in cell cycle control, sterile inflammation and cell death

In Collection
Cell death and survival
Elias S. Weiler, Tamas G. Szabo, Irmina Garcia-Carpio, Andreas Villunger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 813–824.
DOI: https://doi.org/10.1042/BST20211186
Published: 28 March 2022
View article titled, PIDD1 in cell cycle control, sterile inflammation and cell death
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Articles

Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data

Suoqin Jin, Raul Ramos
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 297–308.
DOI: https://doi.org/10.1042/BST20210863
Published: 22 February 2022
View article titled, Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data
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Articles

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

In Collection
Cell death and survival
Sarah E. Garnish, Joanne M. Hildebrand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 529–539.
DOI: https://doi.org/10.1042/BST20210517
Published: 15 February 2022
View article titled, Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
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Articles

Bioimaging approaches for quantification of individual cell behavior during cell fate decisions

Karine R. Begnini, Luiza C. Pereira, Juliano L. Faccioni, Guido Lenz, Eduardo C. Filippi-Chiela
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 513–527.
DOI: https://doi.org/10.1042/BST20210534
Published: 15 February 2022
View article titled, Bioimaging approaches for quantification of individual cell behavior during cell fate decisions
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Articles

The role of IL-36 subfamily in intestinal disease

Peng Xu, Haidi Guan, Weidong Xiao, Lihua Sun
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 223–230.
DOI: https://doi.org/10.1042/BST20211264
Published: 15 February 2022
View article titled, The role of IL-36 subfamily in intestinal disease
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Articles

Inferiority complex: why do sensory ion channels multimerize?

Nikita Gamper, Shihab Shah
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 213–222.
DOI: https://doi.org/10.1042/BST20211002
Published: 15 February 2022
View article titled, Inferiority complex: why do sensory ion channels multimerize?
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Articles

The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation

Daria Sicari, Janine Weber, Elena Maspero, Simona Polo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 473–485.
DOI: https://doi.org/10.1042/BST20210731
Published: 07 February 2022
View article titled, The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation
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Articles

The role of caspases as executioners of apoptosis

In Collection
Cell death and survival
Sharad Kumar, Loretta Dorstyn, Yoon Lim
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 33–45.
DOI: https://doi.org/10.1042/BST20210751
Published: 23 December 2021
View article titled, The role of caspases as executioners of apoptosis
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Articles

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

In Collection
Cell death and survival
Chloe M. McKee, Fabian A. Fischer, Jelena S. Bezbradica, Rebecca C. Coll
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2495–2507.
DOI: https://doi.org/10.1042/BST20200987
Published: 02 December 2021
View article titled, PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling
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Articles

Spatiotemporal regulation of store-operated calcium entry in cancer metastasis

Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2581–2589.
DOI: https://doi.org/10.1042/BST20210307
Published: 02 December 2021
View article titled, Spatiotemporal regulation of store-operated calcium entry in cancer metastasis
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Articles

Role of Rho GTPases in stem cell regulation

Zheng Zhang, Ming Liu, Yi Zheng
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2941–2955.
DOI: https://doi.org/10.1042/BST20211071
Published: 02 December 2021
View article titled, Role of Rho GTPases in stem cell regulation
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