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Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?

Ekaterina Shevchenko, Tatu Pantsar

Biochem Soc Trans (2022) 50 (1): 633–648.

DOI: https://doi.org/10.1042/BST20210837

Published: 28 February 2022

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Articles

Npt2a as a target for treating hyperphosphatemia

Linto Thomas, Jessica A. Dominguez Rieg, Timo Rieg

Biochem Soc Trans (2022) 50 (1): 439–446.

DOI: https://doi.org/10.1042/BST20211005

Published: 07 January 2022

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Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott

Biochem Soc Trans (2021) 49 (5): 2253–2269.

DOI: https://doi.org/10.1042/BST20210343

Published: 28 October 2021

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Articles

Profiling novel pharmacology of receptor complexes using Receptor-HIT

Elizabeth K.M. Johnstone, Kevin D.G. Pfleger

Biochem Soc Trans (2021) 49 (4): 1555–1565.

DOI: https://doi.org/10.1042/BST20201110

Published: 26 August 2021

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Articles

The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update

Laura E. Kilpatrick, Stephen J. Hill

Biochem Soc Trans (2021) 49 (4): 1547–1554.

DOI: https://doi.org/10.1042/BST20201001

Published: 26 August 2021

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Articles

Organ-on-chip applications in drug discovery: an end user perspective

Naomi Clapp, Augustin Amour, Wendy C. Rowan, Pelin L. Candarlioglu

Biochem Soc Trans (2021) 49 (4): 1881–1890.

DOI: https://doi.org/10.1042/BST20210840

Published: 16 August 2021

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Articles

Emerging roles of adhesion G protein-coupled receptors

Matthew Rosa, Timothy Noel, Matthew Harris, Graham Ladds

Biochem Soc Trans (2021) 49 (4): 1695–1709.

DOI: https://doi.org/10.1042/BST20201144

Published: 20 July 2021

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Articles

Latest update on chemokine receptors as therapeutic targets

Wing Yee Lai, Anja Mueller

Biochem Soc Trans (2021) 49 (3): 1385–1395.

DOI: https://doi.org/10.1042/BST20201114

Published: 01 June 2021

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Articles

Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance

Yoshinori Marunaka

Biochem Soc Trans (2021) 49 (2): 715–726.

DOI: https://doi.org/10.1042/BST20200667

Published: 26 March 2021

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Articles

The development of proteinase-activated receptor-2 modulators and the challenges involved

Kathryn A. McIntosh, Margaret R. Cunningham, Trevor Bushell, Robin Plevin

Biochem Soc Trans (2020) 48 (6): 2525–2537.

DOI: https://doi.org/10.1042/BST20200191

Published: 26 November 2020

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Articles

Allosteric inhibition of LRRK2, where are we now

Ahmed Soliman, Fatma Nihan Cankara, Arjan Kortholt

Biochem Soc Trans (2020) 48 (5): 2185–2194.

DOI: https://doi.org/10.1042/BST20200424

Published: 20 October 2020

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Articles

Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors

Gert N. Moll, Anneke Kuipers, Rick Rink, Tjibbe Bosma, Louwe de Vries, Pawel Namsolleck

Biochem Soc Trans (2020) 48 (5): 2195–2203.

DOI: https://doi.org/10.1042/BST20200427

Published: 14 October 2020

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Articles

Inhibition of RAS: proven and potential vulnerabilities

Mariyam Zuberi, Imran Khan, John P. O'Bryan

Biochem Soc Trans (2020) 48 (5): 1831–1841.

DOI: https://doi.org/10.1042/BST20190023

Published: 01 September 2020

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Articles

The evolutionary dynamics of venom toxins made by insects and other animals

Andrew A. Walker

Biochem Soc Trans (2020) 48 (4): 1353–1365.

DOI: https://doi.org/10.1042/BST20190820

Published: 05 August 2020

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Articles

Targeting MmpL3 for anti-tuberculosis drug development

Jani R. Bolla

Biochem Soc Trans (2020) 48 (4): 1463–1472.

DOI: https://doi.org/10.1042/BST20190950

Published: 14 July 2020

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Articles

Nanodomains in cardiopulmonary disorders and the impact of air pollution

Isabella Cattani-Cavalieri, Samuel dos Santos Valença, Martina Schmidt

Biochem Soc Trans (2020) 48 (3): 799–811.

DOI: https://doi.org/10.1042/BST20190250

Published: 29 June 2020

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Articles

Inhibitors in AKTion: ATP-competitive vs allosteric

Glorianne Lazaro, Eleftherios Kostaras, Igor Vivanco

Biochem Soc Trans (2020) 48 (3): 933–943.

DOI: https://doi.org/10.1042/BST20190777

Published: 26 May 2020

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Articles

Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity

Sophie L. Penman, Alice S. Carter, Amy E. Chadwick

Biochem Soc Trans (2020) 48 (3): 787–797.

DOI: https://doi.org/10.1042/BST20190233

Published: 26 May 2020

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Articles

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Jia Jin Hiu, Michelle Khai Khun Yap

Biochem Soc Trans (2020) 48 (2): 719–731.

DOI: https://doi.org/10.1042/BST20200110

Published: 08 April 2020

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Articles

Small molecules that target the ubiquitin system

Hai Qiu Wu, David Baker, Huib Ovaa

Biochem Soc Trans (2020) 48 (2): 479–497.

DOI: https://doi.org/10.1042/BST20190535

Published: 20 March 2020

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Articles

Studying signal compartmentation in adult cardiomyocytes

Aleksandra Judina, Julia Gorelik, Peter T. Wright

Biochem Soc Trans (2020) 48 (1): 61–70.

DOI: https://doi.org/10.1042/BST20190247

Published: 27 February 2020

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Articles

New aspects in cardiac L-type Ca 2+ channel regulation

Tamara Pallien, Enno Klussmann

Biochem Soc Trans (2020) 48 (1): 39–49.

DOI: https://doi.org/10.1042/BST20190229

Published: 17 February 2020

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Articles

Amphipathic molecules modulate PIEZO1 activity

Charles D. Cox, Philip A. Gottlieb

Biochem Soc Trans (2019) 47 (6): 1833–1842.

DOI: https://doi.org/10.1042/BST20190372

Published: 22 November 2019

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Articles

cGMP signalling in cardiomyocyte microdomains

Nadja I. Bork, Cristina E. Molina, Viacheslav O. Nikolaev

Biochem Soc Trans (2019) 47 (5): 1327–1339.

DOI: https://doi.org/10.1042/BST20190225

Published: 11 October 2019

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Articles

Swimming regulations for protein kinase A catalytic subunit

Matthew G. Gold

Biochem Soc Trans (2019) 47 (5): 1355–1366.

DOI: https://doi.org/10.1042/BST20190230

Published: 11 October 2019

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Articles

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Brendan Farrell, Alexander L. Breeze

Biochem Soc Trans (2018) 46 (6): 1753–1770.

DOI: https://doi.org/10.1042/BST20180004

Published: 13 December 2018

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Articles

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

Obinna C. Ubah, Magdalena J. Buschhaus, Laura Ferguson, Marina Kovaleva, John Steven, Andrew J. Porter, Caroline J. Barelle

Biochem Soc Trans (2018) 46 (6): 1559–1565.

DOI: https://doi.org/10.1042/BST20180177

Published: 31 October 2018

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Articles

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

Régis Stentz, Ana L. Carvalho, Emily J. Jones, Simon R. Carding

Biochem Soc Trans (2018) 46 (5): 1021–1027.

DOI: https://doi.org/10.1042/BST20180114

Published: 28 August 2018

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Articles

Ras proteins as therapeutic targets

Atanu Chakraborty, Emily Linnane, Sarah Ross

Biochem Soc Trans (2018) 46 (5): 1303–1311.

DOI: https://doi.org/10.1042/BST20170529

Published: 28 August 2018

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Articles

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease

Courtney J. Mycroft-West, Edwin A. Yates, Mark A. Skidmore

Biochem Soc Trans (2018) 46 (4): 919–929.

DOI: https://doi.org/10.1042/BST20170404

Published: 19 July 2018

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Articles

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald, Katy Barnes, Christopher Hastings, Heather Mortiboys

Biochem Soc Trans (2018) 46 (4): 891–909.

DOI: https://doi.org/10.1042/BST20170501

Published: 19 July 2018

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Articles

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Thomas Briston, Amy R. Hicks

Biochem Soc Trans (2018) 46 (4): 829–842.

DOI: https://doi.org/10.1042/BST20180025

Published: 09 July 2018

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Articles

MSC exosome works through a protein-based mechanism of action

Wei Seong Toh, Ruenn Chai Lai, Bin Zhang, Sai Kiang Lim

Biochem Soc Trans (2018) 46 (4): 843–853.

DOI: https://doi.org/10.1042/BST20180079

Published: 09 July 2018

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Articles

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Dunja Aksentijevic, Brett A. O'Brien, Thomas R. Eykyn, Michael J. Shattock

Biochem Soc Trans (2018) 46 (4): 817–827.

DOI: https://doi.org/10.1042/BST20170508

Published: 03 July 2018

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Articles

Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology

Lisa M. Ebert, Wenbo Yu, Tessa Gargett, Michael P. Brown

Biochem Soc Trans (2018) 46 (2): 391–401.

DOI: https://doi.org/10.1042/BST20170178

Published: 14 March 2018

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Articles

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

David Mellis, Andrea Caporali

Biochem Soc Trans (2018) 46 (1): 11–21.

DOI: https://doi.org/10.1042/BST20170037

Published: 01 December 2017

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Articles

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Scott W. Burnside, Giles E. Hardingham

Biochem Soc Trans (2017) 45 (6): 1295–1303.

DOI: https://doi.org/10.1042/BST20170013

Published: 17 November 2017

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Articles

Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms

Bernd Gesslbauer, Valery Bochkov

Biochem Soc Trans (2017) 45 (6): 1225–1252.

DOI: https://doi.org/10.1042/BST20160473

Published: 03 November 2017

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Articles

Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic–ischaemic brain injury

Claire Thornton, Ana A. Baburamani, Anton Kichev, Henrik Hagberg

Biochem Soc Trans (2017) 45 (5): 1067–1076.

DOI: https://doi.org/10.1042/BST20170017

Published: 22 September 2017

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Articles

Targeting the hepatocyte growth factor/Met pathway in cancer

Dinuka M. De Silva, Arpita Roy, Takashi Kato, Fabiola Cecchi, Young H. Lee, Kunio Matsumoto, Donald P. Bottaro

Biochem Soc Trans (2017) 45 (4): 855–870.

DOI: https://doi.org/10.1042/BST20160132

Published: 03 July 2017

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Articles

Exercise protects from cancer through regulation of immune function and inflammation

Pernille Hojman

Biochem Soc Trans (2017) 45 (4): 905–911.

DOI: https://doi.org/10.1042/BST20160466

Published: 03 July 2017

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Articles

Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis

Ibrahim H. Yaseen, Peter N. Monk, Lynda J. Partridge

Biochem Soc Trans (2017) 45 (2): 465–475.

DOI: https://doi.org/10.1042/BST20160022

Published: 13 April 2017

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Articles

Palmitoylation of proteins in cancer

Marilyn D. Resh

Biochem Soc Trans (2017) 45 (2): 409–416.

DOI: https://doi.org/10.1042/BST20160233

Published: 13 April 2017

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Articles

Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance

Arun Prasad Pandurangan, David B. Ascher, Sherine E. Thomas, Tom L. Blundell

Biochem Soc Trans (2017) 45 (2): 303–311.

DOI: https://doi.org/10.1042/BST20160422

Published: 13 April 2017

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Articles

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation

Md. Shariful Islam, Darren J. Moore

Biochem Soc Trans (2017) 45 (1): 163–172.

DOI: https://doi.org/10.1042/BST20160264

Published: 15 February 2017

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Articles

Targeting PAK1

Galina Semenova, Jonathan Chernoff

Biochem Soc Trans (2017) 45 (1): 79–88.

DOI: https://doi.org/10.1042/BST20160134

Published: 15 February 2017

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Articles

Harnessing the BMP signaling pathway to control the formation of cancer stem cells by effects on epithelial-to-mesenchymal transition

Ashish Bosukonda, William D. Carlson

Biochem Soc Trans (2017) 45 (1): 223–228.

DOI: https://doi.org/10.1042/BST20160177

Published: 15 February 2017

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Novel biomarkers in kidney disease: roles for cilia, Wnt signalling and ATMIN in polycystic kidney disease

Paraskevi Goggolidou, Patricia D. Wilson

Biochem Soc Trans (2016) 44 (6): 1745–1751.

DOI: https://doi.org/10.1042/BST20160124

Published: 02 December 2016

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Dichotomous roles of TGF-β in human cancer

Jennifer J. Huang, Gerard C. Blobe

Biochem Soc Trans (2016) 44 (5): 1441–1454.

DOI: https://doi.org/10.1042/BST20160065

Published: 19 October 2016

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Toward a therapy for mitochondrial disease

Carlo Viscomi

Biochem Soc Trans (2016) 44 (5): 1483–1490.

DOI: https://doi.org/10.1042/BST20160085

Published: 19 October 2016

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