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GPX4: old lessons, new features

Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Irina Ingold

Biochem Soc Trans (2022) 50 (3): 1205–1213.

DOI: https://doi.org/10.1042/BST20220682

Published: 27 June 2022

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Articles

Investigating chromatin accessibility during development and differentiation by ATAC-sequencing to guide the identification of cis -regulatory elements

Emily Louise Smith, Gi Fay Mok, Andrea Münsterberg

Biochem Soc Trans (2022) 50 (3): 1167–1177.

DOI: https://doi.org/10.1042/BST20210834

Published: 23 May 2022

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Articles

Emerging roles of lncRNAs in the pathogenesis, diagnosis, and treatment of trigeminal neuralgia

Tianyi Wang, Liu Liu, Dongzhe Song, Dingming Huang

Biochem Soc Trans (2022) 50 (2): 1013–1023.

DOI: https://doi.org/10.1042/BST20220070

Published: 19 April 2022

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Articles

Three-dimensional models of the lung: past, present and future: a mini review

Chandani Sen, Delilah Freund, Brigitte N. Gomperts

Biochem Soc Trans (2022) 50 (2): 1045–1056.

DOI: https://doi.org/10.1042/BST20190569

Published: 11 April 2022

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Articles

MicroRNAs in neural crest development and neurocristopathies

Marco Antonaci, Grant N. Wheeler

Biochem Soc Trans (2022) 50 (2): 965–974.

DOI: https://doi.org/10.1042/BST20210828

Published: 06 April 2022

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Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Steven R. Van Doren

Biochem Soc Trans (2022) 50 (2): 839–851.

DOI: https://doi.org/10.1042/BST20210640

Published: 28 March 2022

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Articles

Linear ubiquitination in immune and neurodegenerative diseases, and beyond

Fuminori Tokunaga, Fumiyo Ikeda

Biochem Soc Trans (2022) 50 (2): 799–811.

DOI: https://doi.org/10.1042/BST20211078

Published: 28 March 2022

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Articles

Spatial sequestration of misfolded proteins in neurodegenerative diseases

Sarah Rolli, Emily Mitchell Sontag

Biochem Soc Trans (2022) 50 (2): 759–771.

DOI: https://doi.org/10.1042/BST20210862

Published: 21 March 2022

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Articles

GCN2: roles in tumour development and progression

Lyssa T. Gold, Glenn R. Masson

Biochem Soc Trans (2022) 50 (2): 737–745.

DOI: https://doi.org/10.1042/BST20211252

Published: 21 March 2022

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Articles

Drug repurposing in silico screening platforms

Jonathan G.L. Mullins

Biochem Soc Trans (2022) 50 (2): 747–758.

DOI: https://doi.org/10.1042/BST20200967

Published: 14 March 2022

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Articles

Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway

Federica Albanese, Chiara Domenicale, Mattia Volta, Michele Morari

Biochem Soc Trans (2022) 50 (1): 621–632.

DOI: https://doi.org/10.1042/BST20211288

Published: 28 February 2022

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Articles

Role of macrophage extracellular traps in innate immunity and inflammatory disease

Kristian H. Rasmussen, Clare L. Hawkins

Biochem Soc Trans (2022) 50 (1): 21–32.

DOI: https://doi.org/10.1042/BST20210962

Published: 22 February 2022

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Articles

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

Sarah E. Garnish, Joanne M. Hildebrand

Biochem Soc Trans (2022) 50 (1): 529–539.

DOI: https://doi.org/10.1042/BST20210517

Published: 15 February 2022

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Articles

The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation

Daria Sicari, Janine Weber, Elena Maspero, Simona Polo

Biochem Soc Trans (2022) 50 (1): 473–485.

DOI: https://doi.org/10.1042/BST20210731

Published: 07 February 2022

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Articles

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza, Alexandra M. Blee, Walter J. Chazin

Biochem Soc Trans (2022) 50 (1): 375–386.

DOI: https://doi.org/10.1042/BST20210246

Published: 25 January 2022

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Articles

Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)

Jai Woo Lee, Miguel A. Maria-Solano, Thi Ngoc Lan Vu, Sanghee Yoon, Sun Choi

Biochem Soc Trans (2022) 50 (1): 241–252.

DOI: https://doi.org/10.1042/BST20211240

Published: 25 January 2022

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Articles

Three-dimensional insights into human enveloped viruses in vitro and in situ

Naveen Vankadari, Doulin C. Shepherd, Stephen D. Carter, Debnath Ghosal

Biochem Soc Trans (2022) 50 (1): 95–105.

DOI: https://doi.org/10.1042/BST20210433

Published: 25 January 2022

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Articles

The molecular pathogenesis of repeat expansion diseases

Yuzo Fujino, Yoshitaka Nagai

Biochem Soc Trans (2022) 50 (1): 119–134.

DOI: https://doi.org/10.1042/BST20200143

Published: 23 December 2021

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Articles

Identifying new molecular players in extracellular proteostasis

Sandeep Satapathy, Mark R. Wilson

Biochem Soc Trans (2022) 50 (1): 321–334.

DOI: https://doi.org/10.1042/BST20210369

Published: 23 December 2021

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Articles

Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesity

Le Zhao, Haili Yang, Xingchun Li, Yongju Zhao

Biochem Soc Trans (2022) 50 (1): 447–457.

DOI: https://doi.org/10.1042/BST20211031

Published: 23 December 2021

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Articles

VDAC2 and the BCL-2 family of proteins

Zheng Yuan, Grant Dewson, Peter E. Czabotar, Richard W. Birkinshaw

Biochem Soc Trans (2021) 49 (6): 2787–2795.

DOI: https://doi.org/10.1042/BST20210753

Published: 16 December 2021

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Articles

HSP90 as a regulator of extracellular matrix dynamics

Abir Chakraborty, Adrienne Lesley Edkins

Biochem Soc Trans (2021) 49 (6): 2611–2625.

DOI: https://doi.org/10.1042/BST20210374

Published: 16 December 2021

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Articles

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

Chloe M. McKee, Fabian A. Fischer, Jelena S. Bezbradica, Rebecca C. Coll

Biochem Soc Trans (2021) 49 (6): 2495–2507.

DOI: https://doi.org/10.1042/BST20200987

Published: 02 December 2021

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Articles

The role of chromatin at transcription-replication conflicts as a genome safeguard

Aleix Bayona-Feliu, Andrés Aguilera

Biochem Soc Trans (2021) 49 (6): 2727–2736.

DOI: https://doi.org/10.1042/BST20210691

Published: 25 November 2021

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Articles

Insights into neurodegeneration from electron microscopy studies

R. Anthony Crowther

Biochem Soc Trans (2021) 49 (6): 2777–2786.

DOI: https://doi.org/10.1042/BST20210719

Published: 23 November 2021

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Articles

The role of protein acetylation in regulating mitochondrial fusion and fission

Golam M. Uddin, Rafa Abbas, Timothy E. Shutt

Biochem Soc Trans (2021) 49 (6): 2807–2819.

DOI: https://doi.org/10.1042/BST20210798

Published: 23 November 2021

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Articles

LUBAC: a new player in polyglucosan body disease

Andrew Aboujaoude, Berge Minassian, Sharmistha Mitra

Biochem Soc Trans (2021) 49 (5): 2443–2454.

DOI: https://doi.org/10.1042/BST20210838

Published: 28 October 2021

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Articles

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

Marina Diotallevi, Faseeha Ayaz, Thomas Nicol, Mark J. Crabtree

Biochem Soc Trans (2021) 49 (5): 2189–2198.

DOI: https://doi.org/10.1042/BST20210269

Published: 19 October 2021

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Articles

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

W. Douglas Fairlie, Erinna F. Lee

Biochem Soc Trans (2021) 49 (5): 2397–2410.

DOI: https://doi.org/10.1042/BST20210750

Published: 28 September 2021

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Articles

LRRK2 along the Golgi and lysosome connection: a jamming situation

Giovanni Piccoli, Mattia Volta

Biochem Soc Trans (2021) 49 (5): 2063–2072.

DOI: https://doi.org/10.1042/BST20201146

Published: 08 September 2021

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Articles

Modulating cell differentiation in cancer models

Paola Fulghieri, Lucia Anna Stivala, Virginie Sottile

Biochem Soc Trans (2021) 49 (4): 1803–1816.

DOI: https://doi.org/10.1042/BST20210230

Published: 26 August 2021

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Articles

Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

Aaron D. Krabill, Zhong-Yin Zhang

Biochem Soc Trans (2021) 49 (4): 1723–1734.

DOI: https://doi.org/10.1042/BST20201308

Published: 25 August 2021

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Articles

The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities

Julia Varga, Marie Kube, Katja Luck, Sandra Schick

Biochem Soc Trans (2021) 49 (4): 1489–1503.

DOI: https://doi.org/10.1042/BST20190960

Published: 25 August 2021

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Includes: Supplementary data

Articles

Advances in microglia cellular models: focus on extracellular vesicle production

Lorenzo Ceccarelli, Laura Marchetti, Chiara Giacomelli, Claudia Martini

Biochem Soc Trans (2021) 49 (4): 1791–1802.

DOI: https://doi.org/10.1042/BST20210203

Published: 20 August 2021

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Articles

Microglia extracellular vesicles: focus on molecular composition and biological function

Lorenzo Ceccarelli, Chiara Giacomelli, Laura Marchetti, Claudia Martini

Biochem Soc Trans (2021) 49 (4): 1779–1790.

DOI: https://doi.org/10.1042/BST20210202

Published: 20 August 2021

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Articles

Cellular feedback dynamics and multilevel regulation driven by the hippo pathway

Jiwon Park, Carsten Gram Hansen

Biochem Soc Trans (2021) 49 (4): 1515–1527.

DOI: https://doi.org/10.1042/BST20200253

Published: 10 August 2021

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Articles

Host ADP-ribosylation and the SARS-CoV-2 macrodomain

Nicolas C. Hoch

Biochem Soc Trans (2021) 49 (4): 1711–1721.

DOI: https://doi.org/10.1042/BST20201212

Published: 05 August 2021

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Articles

Ion channels as convergence points in the pathology of pulmonary arterial hypertension

Thibault R. H. Jouen-Tachoire, Stephen J. Tucker, Paolo Tammaro

Biochem Soc Trans (2021) 49 (4): 1855–1865.

DOI: https://doi.org/10.1042/BST20210538

Published: 04 August 2021

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Articles

Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease

Iris Verbinnen, Pieter Vaneynde, Sara Reynhout, Lisa Lenaerts, Rita Derua, Gunnar Houge, Veerle Janssens

Biochem Soc Trans (2021) 49 (4): 1567–1588.

DOI: https://doi.org/10.1042/BST20201313

Published: 09 July 2021

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Articles

The Eyes Absent proteins in development and in developmental disorders

Upendra Kumar Soni, Kaushik Roychoudhury, Rashmi S. Hegde

Biochem Soc Trans (2021) 49 (3): 1397–1408.

DOI: https://doi.org/10.1042/BST20201302

Published: 01 July 2021

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Articles

Molecular subversion of Cdc42 signalling in cancer

Natasha P. Murphy, Ana Masara binti Ahmad Mokhtar, Helen R. Mott, Darerca Owen

Biochem Soc Trans (2021) 49 (3): 1425–1442.

DOI: https://doi.org/10.1042/BST20200557

Published: 01 July 2021

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Articles

The cellular pathways and potential therapeutics of Polycystic Kidney Disease

Taylor Richards, Kavindiya Modarage, Soniya A. Malik, Paraskevi Goggolidou

Biochem Soc Trans (2021) 49 (3): 1171–1188.

DOI: https://doi.org/10.1042/BST20200757

Published: 22 June 2021

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Articles

The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage

Aymeric P. Bailly, Dimitris P. Xirodimas

Biochem Soc Trans (2021) 49 (3): 1075–1083.

DOI: https://doi.org/10.1042/BST20200381

Published: 22 June 2021

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Articles

Roles for growth factors and mutations in metastatic dissemination

Nishanth Belugali Nataraj, Ilaria Marrocco, Yosef Yarden

Biochem Soc Trans (2021) 49 (3): 1409–1423.

DOI: https://doi.org/10.1042/BST20210048

Published: 08 June 2021

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Articles

Progress in the therapeutic inhibition of Cdc42 signalling

Natasha P. Murphy, Helen R. Mott, Darerca Owen

Biochem Soc Trans (2021) 49 (3): 1443–1456.

DOI: https://doi.org/10.1042/BST20210112

Published: 08 June 2021

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Articles

The role of splicing factors in retinitis pigmentosa: links to cilia

Dale W. Maxwell, Raymond T. O'Keefe, Sudipto Roy, Kathryn E. Hentges

Biochem Soc Trans (2021) 49 (3): 1221–1231.

DOI: https://doi.org/10.1042/BST20200798

Published: 01 June 2021

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Articles

Molecular genetics of renal ciliopathies

Miguel Barroso-Gil, Eric Olinger, John A. Sayer

Biochem Soc Trans (2021) 49 (3): 1205–1220.

DOI: https://doi.org/10.1042/BST20200791

Published: 07 May 2021

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Articles

Leucine-rich repeat kinase 2-related functions in GLIA: an update of the last years

Alice Filippini, Massimo Gennarelli, Isabella Russo

Biochem Soc Trans (2021) 49 (3): 1375–1384.

DOI: https://doi.org/10.1042/BST20201092

Published: 07 May 2021

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Articles

Methods to study the structure of misfolded protein states in systemic amyloidosis

Marcus Fändrich, Matthias Schmidt

Biochem Soc Trans (2021) 49 (2): 977–985.

DOI: https://doi.org/10.1042/BST20201022

Published: 30 April 2021

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Articles

Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms

Márcio Simão, M. Leonor Cancela

Biochem Soc Trans (2021) 49 (2): 747–759.

DOI: https://doi.org/10.1042/BST20200672

Published: 30 April 2021

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