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Articles

Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction

Shanelle De Silva, Zhijuan Fan, Baoqiang Kang, Catherine M. Shanahan, Qiuping Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221541.
DOI: https://doi.org/10.1042/BST20221541
Published: 12 May 2023
View article titled, Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction
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Articles

Pleiotropy of C1QL proteins across physiological systems and their emerging role in synapse homeostasis

Perla A. Peña Palomino, Kylie C. Black, Susanne Ressl
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220439.
DOI: https://doi.org/10.1042/BST20220439
Published: 04 May 2023
View article titled, Pleiotropy of C1QL proteins across physiological systems and their emerging role in synapse homeostasis
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Articles

Novel roles for G protein-coupled receptor kinases in cardiac injury and repair

Gizem Kayki-Mutlu, Walter J. Koch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 715–724.
DOI: https://doi.org/10.1042/BST20221317
Published: 04 April 2023
View article titled, Novel roles for G protein-coupled receptor kinases in cardiac injury and repair
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Articles

The role of the blood–brain barrier during neurological disease and infection

Adjanie Patabendige, Damir Janigro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 613–626.
DOI: https://doi.org/10.1042/BST20220830
Published: 17 March 2023
View article titled, The role of the blood–brain barrier during neurological disease and infection
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Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Heather M. Wilson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1673–1682.
DOI: https://doi.org/10.1042/BST20220441
Published: 23 November 2022
View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis
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Articles

Transcriptional plasticity of fibroblasts in heart disease

Rudi Micheletti, Michael Alexanian
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1247–1255.
DOI: https://doi.org/10.1042/BST20210864
Published: 25 October 2022
View article titled, Transcriptional plasticity of fibroblasts in heart disease
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Articles

In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence

Roshana Thambyrajah, Rui Monteiro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 703–712.
DOI: https://doi.org/10.1042/BST20210363
Published: 14 March 2022
View article titled, In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence
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Articles

Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Rita Alonaizan, Carolyn Carr
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 269–281.
DOI: https://doi.org/10.1042/BST20210231
Published: 07 February 2022
View article titled, Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation
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Articles

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

Marina Diotallevi, Faseeha Ayaz, Thomas Nicol, Mark J. Crabtree
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2189–2198.
DOI: https://doi.org/10.1042/BST20210269
Published: 19 October 2021
View article titled, Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine
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Articles

Ca 2+ -dependent modulation of voltage-gated myocyte sodium channels

Samantha C. Salvage, Zaki F. Habib, Hugh R. Matthews, Antony P. Jackson, Christopher L.-H. Huang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 1941–1961.
DOI: https://doi.org/10.1042/BST20200604
Published: 13 October 2021
View article titled, Ca 2+ -dependent modulation of voltage-gated myocyte sodium channels
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Articles

Bioengineering silk into blood vessels

Yuen Ting Lam, Richard P. Tan, Praveesuda L. Michael, Kieran Lau, Nianji Yang, Jelena Rnjak-Kovacina, Steven G. Wise
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2271–2286.
DOI: https://doi.org/10.1042/BST20210359
Published: 08 September 2021
View article titled, Bioengineering silk into blood vessels
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Articles

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases

Matthew D. Worssam, Helle F. Jørgensen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2101–2111.
DOI: https://doi.org/10.1042/BST20210138
Published: 08 September 2021
View article titled, Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
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Articles

Ion channels as convergence points in the pathology of pulmonary arterial hypertension

Thibault R. H. Jouen-Tachoire, Stephen J. Tucker, Paolo Tammaro
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1855–1865.
DOI: https://doi.org/10.1042/BST20210538
Published: 04 August 2021
View article titled, Ion channels as convergence points in the pathology of pulmonary arterial hypertension
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Articles

The Hitchhiker's guide to glycoproteomics

Tiago Oliveira, Morten Thaysen-Andersen, Nicolle H. Packer, Daniel Kolarich
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1643–1662.
DOI: https://doi.org/10.1042/BST20200879
Published: 20 July 2021
View article titled, The Hitchhiker's guide to glycoproteomics
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Articles

Methodology to detect oxidised phospholipids and their relevance in disease

Ahilanandan Dushianthan, Anthony Postle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1241–1250.
DOI: https://doi.org/10.1042/BST20200852
Published: 07 May 2021
View article titled, Methodology to detect oxidised phospholipids and their relevance in disease
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Articles

Bioengineered in vitro models of leukocyte–vascular interactions

Jaehyun Lee, Cort B. Breuer, Esak Lee
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 693–704.
DOI: https://doi.org/10.1042/BST20200620
Published: 12 April 2021
View article titled, Bioengineered in vitro models of leukocyte–vascular interactions
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Articles

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking

Kazuaki Yoshioka
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 893–901.
DOI: https://doi.org/10.1042/BST20200835
Published: 05 March 2021
View article titled, Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking
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Articles

Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease

Ashton Faulkner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 507–517.
DOI: https://doi.org/10.1042/BST20200991
Published: 22 February 2021
View article titled, Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease
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Articles

Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease

Kirsten Riches-Suman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 353–363.
DOI: https://doi.org/10.1042/BST20200679
Published: 22 February 2021
View article titled, Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease
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Articles

Endothelial response to glucose: dysfunction, metabolism, and transport

Alisa Morss Clyne
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 313–325.
DOI: https://doi.org/10.1042/BST20200611
Published: 01 February 2021
View article titled, Endothelial response to glucose: dysfunction, metabolism, and transport
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Articles

Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities

Hongyang Shu, Yizhong Peng, Weijian Hang, Ning Zhou, Dao Wen Wang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 485–494.
DOI: https://doi.org/10.1042/BST20200981
Published: 13 January 2021
View article titled, Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities
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Articles

Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Asal Ghaffari Zaki, Yusuf C. Erdoğan, Tuba Akgul Caglar, Emrah Eroglu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 335–345.
DOI: https://doi.org/10.1042/BST20210506
Published: 11 January 2021
View article titled, Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors
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Articles

New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics

Crisdion Krstevski, Charles D. Cohen, Malathi S.I. Dona, Alexander R. Pinto
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2483–2493.
DOI: https://doi.org/10.1042/BST20191255
Published: 01 December 2020
View article titled, New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics
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Articles

Function and regulation of corin in physiology and disease

Ningzheng Dong, Yayan Niu, Yue Chen, Shijin Sun, Qingyu Wu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1905–1916.
DOI: https://doi.org/10.1042/BST20190760
Published: 14 October 2020
View article titled, Function and regulation of corin in physiology and disease
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Articles

Role of the adaptive immune system in atherosclerosis

Klaus Ley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2273–2281.
DOI: https://doi.org/10.1042/BST20200602
Published: 01 September 2020
View article titled, Role of the adaptive immune system in atherosclerosis
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Articles

Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering

Daniel Kirchhofer, Daniel J. Burdick, Nicholas J. Skelton, Yingnan Zhang, Mark Ultsch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1323–1336.
DOI: https://doi.org/10.1042/BST20190672
Published: 14 August 2020
View article titled, Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering
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Articles

Nanodomains in cardiopulmonary disorders and the impact of air pollution

Isabella Cattani-Cavalieri, Samuel dos Santos Valença, Martina Schmidt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 799–811.
DOI: https://doi.org/10.1042/BST20190250
Published: 29 June 2020
View article titled, Nanodomains in cardiopulmonary disorders and the impact of air pollution
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Articles

Studying signal compartmentation in adult cardiomyocytes

Aleksandra Judina, Julia Gorelik, Peter T. Wright
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 61–70.
DOI: https://doi.org/10.1042/BST20190247
Published: 27 February 2020
View article titled, Studying signal compartmentation in adult cardiomyocytes
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Articles

New aspects in cardiac L-type Ca 2+ channel regulation

Tamara Pallien, Enno Klussmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 39–49.
DOI: https://doi.org/10.1042/BST20190229
Published: 17 February 2020
View article titled, New aspects in cardiac L-type Ca 2+ channel regulation
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Articles

The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology

Cerrone R. Foster, Shiho Satomi, Yuko Kato, Hemal H. Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 165–177.
DOI: https://doi.org/10.1042/BST20190388
Published: 03 February 2020
View article titled, The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology
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Articles

Nanometric targeting of type 9 adenylyl cyclase in heart

Autumn N. Marsden, Carmen W. Dessauer
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1749–1756.
DOI: https://doi.org/10.1042/BST20190227
Published: 26 November 2019
View article titled, Nanometric targeting of type 9 adenylyl cyclase in heart
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Articles

Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Mavis A.A. Tenkorang, Upendra Chalise, Michael J. Daseke, II, Shelby R. Konfrst, Merry L. Lindsey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1679–1687.
DOI: https://doi.org/10.1042/BST20190113
Published: 14 November 2019
View article titled, Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium
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Articles

Imaging cAMP nanodomains in the heart

Ying-Chi Chao, Nicoletta C. Surdo, Sergio Pantano, Manuela Zaccolo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1383–1392.
DOI: https://doi.org/10.1042/BST20190245
Published: 31 October 2019
View article titled, Imaging cAMP nanodomains in the heart
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Articles

cGMP signalling in cardiomyocyte microdomains

Nadja I. Bork, Cristina E. Molina, Viacheslav O. Nikolaev
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1327–1339.
DOI: https://doi.org/10.1042/BST20190225
Published: 11 October 2019
View article titled, cGMP signalling in cardiomyocyte microdomains
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Articles

The role of A-kinase anchoring proteins in cardiac oxidative stress

Dario Diviani, Halima Osman, Marion Delaunay, Simon Kaiser
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1341–1353.
DOI: https://doi.org/10.1042/BST20190228
Published: 11 October 2019
View article titled, The role of A-kinase anchoring proteins in cardiac oxidative stress
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Articles

Extracellular matrix: the gatekeeper of tumor angiogenesis

Maurizio Mongiat, Simone Buraschi, Eva Andreuzzi, Thomas Neill, Renato V. Iozzo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1543–1555.
DOI: https://doi.org/10.1042/BST20190653
Published: 11 October 2019
View article titled, Extracellular matrix: the gatekeeper of tumor angiogenesis
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Articles

POPDC proteins and cardiac function

Thomas Brand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1393–1404.
DOI: https://doi.org/10.1042/BST20190249
Published: 24 September 2019
View article titled, POPDC proteins and cardiac function
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Articles

Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes

Connor M. Blair, George S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1405–1414.
DOI: https://doi.org/10.1042/BST20190252
Published: 10 September 2019
View article titled, Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes
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Articles

The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Lilian Schimmel, Emma Gordon
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1673–1680.
DOI: https://doi.org/10.1042/BST20180377
Published: 04 December 2018
View article titled, The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall
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Articles

Structural snapshots of RAF kinase interactions

Soheila Rezaei Adariani, Marcel Buchholzer, Mohammad Akbarzadeh, Saeideh Nakhaei-Rad, Radovan Dvorsky, Mohammad Reza Ahmadian
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1393–1406.
DOI: https://doi.org/10.1042/BST20170528
Published: 31 October 2018
View article titled, Structural snapshots of RAF kinase interactions
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Includes: Supplementary data
Articles

The creatine kinase system as a therapeutic target for myocardial ischaemia–reperfusion injury

Fang Cao, Sevasti Zervou, Craig A. Lygate
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1119–1127.
DOI: https://doi.org/10.1042/BST20170504
Published: 21 September 2018
View article titled, The creatine kinase system as a therapeutic target for myocardial ischaemia–reperfusion injury
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Articles

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Dunja Aksentijevic, Brett A. O'Brien, Thomas R. Eykyn, Michael J. Shattock
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 817–827.
DOI: https://doi.org/10.1042/BST20170508
Published: 03 July 2018
View article titled, Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
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Articles

Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Julia Y. Chu, Barry McCormick, Sonja Vermeren
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 649–658.
DOI: https://doi.org/10.1042/BST20170530
Published: 09 May 2018
View article titled, Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation
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Articles

Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease

Can Zhou, Li Rao, Catherine M. Shanahan, Qiuping Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 311–320.
DOI: https://doi.org/10.1042/BST20170149
Published: 27 February 2018
View article titled, Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease
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Articles

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

David Mellis, Andrea Caporali
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 11–21.
DOI: https://doi.org/10.1042/BST20170037
Published: 01 December 2017
View article titled, MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target
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Articles

Omega-3 fatty acids and inflammatory processes: from molecules to man

Philip C. Calder
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (5): 1105–1115.
DOI: https://doi.org/10.1042/BST20160474
Published: 12 September 2017
View article titled, Omega-3 fatty acids and inflammatory processes: from molecules to man
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Articles

How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Jonas Franz, Marco Tarantola, Christoph Riethmüller
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 999–1006.
DOI: https://doi.org/10.1042/BST20170163
Published: 14 July 2017
View article titled, How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation
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Articles

Fundamental principles of vascular network topology

Veronika S. Kopylova, Stanislav E. Boronovskiy, Yaroslav R. Nartsissov
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 839–844.
DOI: https://doi.org/10.1042/BST20160409
Published: 15 June 2017
View article titled, Fundamental principles of vascular network topology
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Articles

O-GlcNAcylation and cardiovascular disease

JaLessa N. Wright, Helen E. Collins, Adam R. Wende, John C. Chatham
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 545–553.
DOI: https://doi.org/10.1042/BST20160164
Published: 13 April 2017
View article titled, O-GlcNAcylation and cardiovascular disease
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Articles

Can the Drosophila model help in paving the way for translational medicine in heart failure?

Lisha Ma
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1549–1560.
DOI: https://doi.org/10.1042/BST20160017C
Published: 19 October 2016
View article titled, Can the Drosophila model help in paving the way for translational medicine in heart failure?
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