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Articles

Caveolae and the oxidative stress response

Yeping Wu, Ye-Wheen Lim, Robert G. Parton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230121.
DOI: https://doi.org/10.1042/BST20230121
Published: 30 May 2023
View article titled, Caveolae and the oxidative stress response
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Articles

Differential functions of the KRAS splice variants

Juan Kochen Rossi, Cristina Nuevo-Tapioles, Mark R. Philips
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221347.
DOI: https://doi.org/10.1042/BST20221347
Published: 24 May 2023
View article titled, Differential functions of the KRAS splice variants
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Articles

The function and regulation of ADP-ribosylation in the DNA damage response

Lena Duma, Ivan Ahel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220749.
DOI: https://doi.org/10.1042/BST20220749
Published: 12 May 2023
View article titled, The function and regulation of ADP-ribosylation in the DNA damage response
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Articles

The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication

Yuki Hatoyama, Masato T. Kanemaki
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221465.
DOI: https://doi.org/10.1042/BST20221465
Published: 05 May 2023
View article titled, The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication
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Articles

The molecular mechanisms of human separase regulation

Jun Yu, David O. Morgan, Andreas Boland
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221400.
DOI: https://doi.org/10.1042/BST20221400
Published: 04 May 2023
View article titled, The molecular mechanisms of human separase regulation
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Articles

Pleiotropy of C1QL proteins across physiological systems and their emerging role in synapse homeostasis

Perla A. Peña Palomino, Kylie C. Black, Susanne Ressl
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220439.
DOI: https://doi.org/10.1042/BST20220439
Published: 04 May 2023
View article titled, Pleiotropy of C1QL proteins across physiological systems and their emerging role in synapse homeostasis
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Articles

Extracellular vesicles in carcinoma microenvironment

Larissa Tinô de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sá, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 771–781.
DOI: https://doi.org/10.1042/BST20221175
Published: 06 April 2023
View article titled, Extracellular vesicles in carcinoma microenvironment
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Articles

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Jennifer Currenti, Archita Mishra, Michael Wallace, Jacob George, Ankur Sharma
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 597–612.
DOI: https://doi.org/10.1042/BST20220157
Published: 20 March 2023
View article titled, Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response
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Articles

CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision

Laura M. Machesky
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 579–585.
DOI: https://doi.org/10.1042/BST20221354
Published: 09 March 2023
View article titled, CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision
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Articles

cGAS–STING signalling in cancer: striking a balance with chromosomal instability

Bruno Beernaert, Eileen E. Parkes
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 539–555.
DOI: https://doi.org/10.1042/BST20220838
Published: 06 March 2023
View article titled, cGAS–STING signalling in cancer: striking a balance with chromosomal instability
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Articles

Mitochondrial DNA in cell death and inflammation

In Collection
Cell death and survival
Rosalie Heilig, Jordan Lee, Stephen W.G. Tait
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 457–472.
DOI: https://doi.org/10.1042/BST20221525
Published: 23 February 2023
View article titled, Mitochondrial DNA in cell death and inflammation
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Articles

Eliminating oncogenic RAS: back to the future at the drawing board

Candy Laura Steffen, Pelin Kaya, Elisabeth Schaffner-Reckinger, Daniel Abankwa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 447–456.
DOI: https://doi.org/10.1042/BST20221343
Published: 23 January 2023
View article titled, Eliminating oncogenic RAS: back to the future at the drawing board
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Includes: Supplementary data
Articles

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E

Jerry Pelletier, Nahum Sonenberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 113–124.
DOI: https://doi.org/10.1042/BST20220285
Published: 20 January 2023
View article titled, Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
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Articles

Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology

Steven Turner, Jonathan W. Essex, Tim Elliott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 275–285.
DOI: https://doi.org/10.1042/BST20220782
Published: 16 January 2023
View article titled, Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology
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Articles

Therapeutic targeting of TRAIL death receptors

In Collection
Cell death and survival
Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 57–70.
DOI: https://doi.org/10.1042/BST20220098
Published: 11 January 2023
View article titled, Therapeutic targeting of TRAIL death receptors
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Articles

Targeting the DNA damage response for cancer therapy

In Collection
Awards
Nicola J. Curtin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 207–221.
DOI: https://doi.org/10.1042/BST20220681
Published: 06 January 2023
View article titled, Targeting the DNA damage response for cancer therapy
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Articles

The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer

Aristeidis Panagiotis Sfakianos, Rebecca Mallory Raven, Anne Elizabeth Willis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1885–1895.
DOI: https://doi.org/10.1042/BST20221035
Published: 13 December 2022
View article titled, The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer
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Articles

Functional regulation of Wnt protein through post-translational modifications

Jia Yu, David M. Virshup
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1797–1808.
DOI: https://doi.org/10.1042/BST20220735
Published: 09 December 2022
View article titled, Functional regulation of Wnt protein through post-translational modifications
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Articles

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

Sharissa L. Latham, Yolande E.I. O'Donnell, David R. Croucher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1823–1836.
DOI: https://doi.org/10.1042/BST20220808
Published: 01 December 2022
View article titled, Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
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Articles

Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer

Carlos Vela-Rodríguez, Lari Lehtiö
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1683–1692.
DOI: https://doi.org/10.1042/BST20220501
Published: 24 November 2022
View article titled, Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer
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Articles

Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance

Lauren T. Pecorino, Roel G.W. Verhaak, Anton Henssen, Paul S. Mischel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1911–1920.
DOI: https://doi.org/10.1042/BST20221045
Published: 10 November 2022
View article titled, Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance
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Articles

The role of UV-DDB in processing 8-oxoguanine during base excision repair

Ashna Nagpal, Sripriya Raja, Bennett Van Houten
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1481–1488.
DOI: https://doi.org/10.1042/BST20220748
Published: 28 October 2022
View article titled, The role of UV-DDB in processing 8-oxoguanine during base excision repair
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Articles

Cancer cells hijack RNA processing to rewrite the message

Katherine L.B. Borden
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1447–1456.
DOI: https://doi.org/10.1042/BST20220621
Published: 25 October 2022
View article titled, Cancer cells hijack RNA processing to rewrite the message
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Articles

Processing DNA lesions during mitosis to prevent genomic instability

Anastasia Audrey, Lauren de Haan, Marcel A.T.M. van Vugt, H. Rudolf de Boer
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1105–1118.
DOI: https://doi.org/10.1042/BST20220049
Published: 30 August 2022
View article titled, Processing DNA lesions during mitosis to prevent genomic instability
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Articles

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging

Hanwen Zhang, Xiaohui Lin, Shan Zha
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1169–1177.
DOI: https://doi.org/10.1042/BST20220366
Published: 12 August 2022
View article titled, Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging
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Articles

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

Kendelle J. Murphy, Jessie Zhu, Michael Trpceski, Brooke A. Pereira, Paul Timpson, David Herrmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1129–1141.
DOI: https://doi.org/10.1042/BST20220162
Published: 05 August 2022
View article titled, Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy
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Articles

Last but not least: BFL-1 as an emerging target for anti-cancer therapies

Gaoyuan Wang, Sarah T. Diepstraten, Marco J. Herold
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1119–1128.
DOI: https://doi.org/10.1042/BST20220153
Published: 28 July 2022
View article titled, Last but not least: BFL-1 as an emerging target for anti-cancer therapies
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Articles

Tumour invasion and dissemination

Ryan Lusby, Philip Dunne, Vijay K. Tiwari
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1245–1257.
DOI: https://doi.org/10.1042/BST20220452
Published: 17 June 2022
View article titled, Tumour invasion and dissemination
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Articles

Role of SWI/SNF chromatin remodeling genes in lung cancer development

Beatriz Monterde, Ignacio Varela
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1143–1150.
DOI: https://doi.org/10.1042/BST20211084
Published: 19 May 2022
View article titled, Role of SWI/SNF chromatin remodeling genes in lung cancer development
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Articles

Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

In Collection
Cell death and survival
Faustino Mollinedo, Consuelo Gajate
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1105–1118.
DOI: https://doi.org/10.1042/BST20211115
Published: 19 May 2022
View article titled, Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy
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Articles

Daylight-PDT: everything under the sun

Dana Beiki, Ian M. Eggleston, Charareh Pourzand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 975–985.
DOI: https://doi.org/10.1042/BST20200822
Published: 06 April 2022
View article titled, Daylight-PDT: everything under the sun
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Articles

Functional diversity in the RAS subfamily of small GTPases

Gabriela Bernal Astrain, Maya Nikolova, Matthew J. Smith
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 921–933.
DOI: https://doi.org/10.1042/BST20211166
Published: 31 March 2022
View article titled, Functional diversity in the RAS subfamily of small GTPases
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Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Steven R. Van Doren
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 839–851.
DOI: https://doi.org/10.1042/BST20210640
Published: 28 March 2022
View article titled, MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains
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Articles

Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance

Adithya Balasubramanian, Thomas John, Marie-Liesse Asselin-Labat
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 825–837.
DOI: https://doi.org/10.1042/BST20210961
Published: 28 March 2022
View article titled, Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance
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Articles

GCN2: roles in tumour development and progression

Lyssa T. Gold, Glenn R. Masson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 737–745.
DOI: https://doi.org/10.1042/BST20211252
Published: 21 March 2022
View article titled, GCN2: roles in tumour development and progression
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Articles

The intricate roles of RCC1 in normal cells and cancer cells

Li Jing, Hang Fai Kwok
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 83–93.
DOI: https://doi.org/10.1042/BST20210861
Published: 22 February 2022
View article titled, The intricate roles of RCC1 in normal cells and cancer cells
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Articles

Bioimaging approaches for quantification of individual cell behavior during cell fate decisions

Karine R. Begnini, Luiza C. Pereira, Juliano L. Faccioni, Guido Lenz, Eduardo C. Filippi-Chiela
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 513–527.
DOI: https://doi.org/10.1042/BST20210534
Published: 15 February 2022
View article titled, Bioimaging approaches for quantification of individual cell behavior during cell fate decisions
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Articles

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza, Alexandra M. Blee, Walter J. Chazin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 375–386.
DOI: https://doi.org/10.1042/BST20210246
Published: 25 January 2022
View article titled, Mechanism of action of nucleotide excision repair machinery
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Articles

Epigenetic mechanisms in paediatric brain tumours: regulators lose control

Sara Badodi, Silvia Marino
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 167–185.
DOI: https://doi.org/10.1042/BST20201227
Published: 25 January 2022
View article titled, Epigenetic mechanisms in paediatric brain tumours: regulators lose control
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Articles

Isocitrate dehydrogenase gene variants in cancer and their clinical significance

Thomas Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2561–2572.
DOI: https://doi.org/10.1042/BST20210277
Published: 02 December 2021
View article titled, Isocitrate dehydrogenase gene variants in cancer and their clinical significance
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Articles

Spatiotemporal regulation of store-operated calcium entry in cancer metastasis

Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2581–2589.
DOI: https://doi.org/10.1042/BST20210307
Published: 02 December 2021
View article titled, Spatiotemporal regulation of store-operated calcium entry in cancer metastasis
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Articles

Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium

Lisa Scarfe, Gillian M. Mackie, Kendle M. Maslowski
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2601–2610.
DOI: https://doi.org/10.1042/BST20210365
Published: 02 December 2021
View article titled, Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium
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Articles

Role of Rho GTPases in stem cell regulation

Zheng Zhang, Ming Liu, Yi Zheng
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2941–2955.
DOI: https://doi.org/10.1042/BST20211071
Published: 02 December 2021
View article titled, Role of Rho GTPases in stem cell regulation
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Articles

The role of chromatin at transcription-replication conflicts as a genome safeguard

Aleix Bayona-Feliu, Andrés Aguilera
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2727–2736.
DOI: https://doi.org/10.1042/BST20210691
Published: 25 November 2021
View article titled, The role of chromatin at transcription-replication conflicts as a genome safeguard
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Articles

Chromosome clustering in mitosis by the nuclear protein Ki-67

Konstantinos Stamatiou, Paola Vagnarelli
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2767–2776.
DOI: https://doi.org/10.1042/BST20210717
Published: 16 November 2021
View article titled, Chromosome clustering in mitosis by the nuclear protein Ki-67
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Articles

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2253–2269.
DOI: https://doi.org/10.1042/BST20210343
Published: 28 October 2021
View article titled, Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
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Articles

Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer

Marie Sorbara, Nicolas Bery
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2021–2035.
DOI: https://doi.org/10.1042/BST20201059
Published: 08 October 2021
View article titled, Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer
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Articles

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

In Collection
Cell death and survival
W. Douglas Fairlie, Erinna F. Lee
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2397–2410.
DOI: https://doi.org/10.1042/BST20210750
Published: 28 September 2021
View article titled, Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers
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Articles

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

In Collection
Cell death and survival
Erinna F. Lee, W. Douglas Fairlie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2381–2395.
DOI: https://doi.org/10.1042/BST20210749
Published: 13 September 2021
View article titled, Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
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Articles

Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?

Kristina Ehring, Kay Grobe
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2455–2463.
DOI: https://doi.org/10.1042/BST20210918
Published: 13 September 2021
View article titled, Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?
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