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Articles

Fast-forward on P-type ATPases: recent advances on structure and function

Charlott Stock, Tomáš Heger, Sara Basse Hansen, Sigrid Thirup Larsen, Michael Habeck, Thibaud Dieudonné, Ronja Driller, Poul Nissen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221543.
DOI: https://doi.org/10.1042/BST20221543
Published: 02 June 2023
View article titled, Fast-forward on P-type ATPases: recent advances on structure and function
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Articles

Improving the hole picture: towards a consensus on the mechanism of nuclear transport

David Cowburn, Michael Rout
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 871–886.
DOI: https://doi.org/10.1042/BST20220494
Published: 26 April 2023
View article titled, Improving the hole picture: towards a consensus on the mechanism of nuclear transport
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Articles

Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology

Zhengyuan Huang, Pei F. Lai, Alexander T. H. Cocker, Stuart M. Haslam, Anne Dell, Hugh J. M. Brady, Mark R. Johnson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 639–653.
DOI: https://doi.org/10.1042/BST20221406
Published: 16 March 2023
View article titled, Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology
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Articles

Single-molecule tracking (SMT): a window into live-cell transcription biochemistry

Liza Dahal, Nike Walther, Robert Tjian, Xavier Darzacq, Thomas G.W. Graham
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 557–569.
DOI: https://doi.org/10.1042/BST20221242
Published: 06 March 2023
View article titled, Single-molecule tracking (SMT): a window into live-cell transcription biochemistry
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Articles

Towards using 3D cellular cultures to model the activation and diverse functions of macrophages

Sean Cutter, Mark D. Wright, Nicholas P. Reynolds, Katrina Jean Binger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 387–401.
DOI: https://doi.org/10.1042/BST20221008
Published: 06 February 2023
View article titled, Towards using 3D cellular cultures to model the activation and diverse functions of macrophages
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Articles

Eliminating oncogenic RAS: back to the future at the drawing board

Candy Laura Steffen, Pelin Kaya, Elisabeth Schaffner-Reckinger, Daniel Abankwa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 447–456.
DOI: https://doi.org/10.1042/BST20221343
Published: 23 January 2023
View article titled, Eliminating oncogenic RAS: back to the future at the drawing board
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Includes: Supplementary data
Articles

Interactions governing transcriptional activity of nuclear receptors

Sabab Hasan Khan, C. Denise Okafor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1941–1952.
DOI: https://doi.org/10.1042/BST20220338
Published: 16 December 2022
View article titled, Interactions governing transcriptional activity of nuclear receptors
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Articles

General strategies for using amino acid sequence data to guide biochemical investigation of protein function

Emily N. Kennedy, Clay A. Foster, Sarah A. Barr, Robert B. Bourret
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1847–1858.
DOI: https://doi.org/10.1042/BST20220849
Published: 23 November 2022
View article titled, General strategies for using amino acid sequence data to guide biochemical investigation of protein function
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Articles

Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation

Benjamin Rowlinson, Elodie Crublet, Rime Kerfah, Michael J. Plevin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1555–1567.
DOI: https://doi.org/10.1042/BST20210586
Published: 16 November 2022
View article titled, Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation
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Articles

Frankenstein Cas9: engineering improved gene editing systems

Pascal D. Vos, Aleksandra Filipovska, Oliver Rackham
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1505–1516.
DOI: https://doi.org/10.1042/BST20220873
Published: 28 October 2022
View article titled, Frankenstein Cas9: engineering improved gene editing systems
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Articles

Characterising ion channel structure and dynamics using fluorescence spectroscopy techniques

Shreyas Bhat, Rikard Blunck
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1427–1445.
DOI: https://doi.org/10.1042/BST20220605
Published: 25 October 2022
View article titled, Characterising ion channel structure and dynamics using fluorescence spectroscopy techniques
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Articles

A comprehensive review of methods to study lncRNA–protein interactions in solution

Maulik D. Badmalia, Higor Sette Pereira, M. Quadir Siddiqui, Trushar R. Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1415–1426.
DOI: https://doi.org/10.1042/BST20220604
Published: 17 October 2022
View article titled, A comprehensive review of methods to study lncRNA–protein interactions in solution
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Articles

Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques

Chung Yu Chan, Youssef Faragalla, Ling-Gang Wu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1157–1167.
DOI: https://doi.org/10.1042/BST20210263
Published: 12 August 2022
View article titled, Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques
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Articles

AAA+ proteins: one motor, multiple ways to work

JiaBei Lin, James Shorter, Aaron L. Lucius
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 895–906.
DOI: https://doi.org/10.1042/BST20200350
Published: 31 March 2022
View article titled, AAA+ proteins: one motor, multiple ways to work
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Articles

Stop CRYing! Inhibition of cryptochrome function by small proteins

Valdeko Kruusvee, Arendse Maria Toft, Blanche Aguida, Margaret Ahmad, Stephan Wenkel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 773–782.
DOI: https://doi.org/10.1042/BST20190062
Published: 21 March 2022
View article titled, Stop CRYing! Inhibition of cryptochrome function by small proteins
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Articles

A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences

Chidinma Adanna Okolo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 649–663.
DOI: https://doi.org/10.1042/BST20210886
Published: 08 March 2022
View article titled, A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences
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Articles

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

In Collection
Awards
Valerie B. O'Donnell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 1–11.
DOI: https://doi.org/10.1042/BST20210579
Published: 28 February 2022
View article titled, New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
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Articles

How lipids affect the energetics of co-translational alpha helical membrane protein folding

Ryan Brady, Nicola J. Harris, Grant A. Pellowe, Samuel Gulaidi Breen, Paula J. Booth
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 555–567.
DOI: https://doi.org/10.1042/BST20201063
Published: 25 February 2022
View article titled, How lipids affect the energetics of co-translational alpha helical membrane protein folding
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Articles

Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin

Luke T. Marr, Prasoon Jaya, Laxmi N. Mishra, Jeffrey J. Hayes
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 199–212.
DOI: https://doi.org/10.1042/BST20210959
Published: 15 February 2022
View article titled, Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin
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Articles

Multiple roles of Pol epsilon in eukaryotic chromosome replication

Milos A. Cvetkovic, Esther Ortega, Roberto Bellelli, Alessandro Costa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 309–320.
DOI: https://doi.org/10.1042/BST20210082
Published: 07 February 2022
View article titled, Multiple roles of Pol epsilon in eukaryotic chromosome replication
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Articles

Artificial protein assemblies with well-defined supramolecular protein nanostructures

Suyeong Han, Yongwon Jung
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2821–2830.
DOI: https://doi.org/10.1042/BST20210808
Published: 23 November 2021
View article titled, Artificial protein assemblies with well-defined supramolecular protein nanostructures
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Articles

Writing and erasing O- GlcNAc from target proteins in cells

Yun Ge, Christina M. Woo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2891–2901.
DOI: https://doi.org/10.1042/BST20210865
Published: 16 November 2021
View article titled, Writing and erasing O- GlcNAc from target proteins in cells
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Articles

Live-cell visualization of cytochrome c : a tool to explore apoptosis

João Pessoa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2903–2915.
DOI: https://doi.org/10.1042/BST20211028
Published: 08 November 2021
View article titled, Live-cell visualization of cytochrome c : a tool to explore apoptosis
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Articles

Challenges and approaches to studying pore-forming proteins

Joshua T. Benton, Charles Bayly-Jones
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2749–2765.
DOI: https://doi.org/10.1042/BST20210706
Published: 08 November 2021
View article titled, Challenges and approaches to studying pore-forming proteins
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Articles

TOP2B's contributions to transcription

Caroline A. Austin, Ian G. Cowell, Mushtaq M. Khazeem, Dawn Lok, Huei Teng Ng
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2483–2493.
DOI: https://doi.org/10.1042/BST20200454
Published: 08 November 2021
View article titled, TOP2B's contributions to transcription
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Articles

Conquer by cryo-EM without physically dividing

Gabriel C. Lander, Robert M. Glaeser
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2287–2298.
DOI: https://doi.org/10.1042/BST20210360
Published: 28 October 2021
View article titled, Conquer by cryo-EM without physically dividing
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Articles

Controlled metabolic cascades for protein synthesis in an artificial cell

Huong Thanh Nguyen, Sungwoo Lee, Kwanwoo Shin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2143–2151.
DOI: https://doi.org/10.1042/BST20210175
Published: 08 October 2021
View article titled, Controlled metabolic cascades for protein synthesis in an artificial cell
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Articles

The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update

Laura E. Kilpatrick, Stephen J. Hill
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1547–1554.
DOI: https://doi.org/10.1042/BST20201001
Published: 26 August 2021
View article titled, The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update
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Articles

Profiling novel pharmacology of receptor complexes using Receptor-HIT

Elizabeth K.M. Johnstone, Kevin D.G. Pfleger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1555–1565.
DOI: https://doi.org/10.1042/BST20201110
Published: 26 August 2021
View article titled, Profiling novel pharmacology of receptor complexes using Receptor-HIT
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Articles

Advances in microglia cellular models: focus on extracellular vesicle production

Lorenzo Ceccarelli, Laura Marchetti, Chiara Giacomelli, Claudia Martini
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1791–1802.
DOI: https://doi.org/10.1042/BST20210203
Published: 20 August 2021
View article titled, Advances in microglia cellular models: focus on extracellular vesicle production
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Articles

Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation

Giedre Ratkeviciute, Benjamin F. Cooper, Timothy J. Knowles
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1763–1777.
DOI: https://doi.org/10.1042/BST20210181
Published: 20 August 2021
View article titled, Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation
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Articles

Solid state NMR of membrane proteins: methods and applications

Vivien Yeh, Boyan B. Bonev
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1505–1513.
DOI: https://doi.org/10.1042/BST20200070
Published: 16 August 2021
View article titled, Solid state NMR of membrane proteins: methods and applications
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Articles

Organ-on-chip applications in drug discovery: an end user perspective

Naomi Clapp, Augustin Amour, Wendy C. Rowan, Pelin L. Candarlioglu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1881–1890.
DOI: https://doi.org/10.1042/BST20210840
Published: 16 August 2021
View article titled, Organ-on-chip applications in drug discovery: an end user perspective
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Articles

Single-molecule fluorescence vistas of how lipids regulate membrane proteins

Alyssa E. Ward, Yujie Ye, Jennifer A. Schuster, Shushu Wei, Francisco N. Barrera
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1685–1694.
DOI: https://doi.org/10.1042/BST20201074
Published: 04 August 2021
View article titled, Single-molecule fluorescence vistas of how lipids regulate membrane proteins
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Articles

The Hitchhiker's guide to glycoproteomics

Tiago Oliveira, Morten Thaysen-Andersen, Nicolle H. Packer, Daniel Kolarich
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1643–1662.
DOI: https://doi.org/10.1042/BST20200879
Published: 20 July 2021
View article titled, The Hitchhiker's guide to glycoproteomics
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Articles

Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry

Luke A. Clifton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1537–1546.
DOI: https://doi.org/10.1042/BST20201071
Published: 09 July 2021
View article titled, Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry
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Articles

Protein-fragment complementation assays for large-scale analysis of protein–protein interactions

Ewa Blaszczak, Natalia Lazarewicz, Aswani Sudevan, Robert Wysocki, Gwenaël Rabut
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1337–1348.
DOI: https://doi.org/10.1042/BST20201058
Published: 22 June 2021
View article titled, Protein-fragment complementation assays for large-scale analysis of protein–protein interactions
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Articles

Biological insights from SMA-extracted proteins

Lucas Unger, Alejandro Ronco-Campaña, Philip Kitchen, Roslyn M. Bill, Alice J. Rothnie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1349–1359.
DOI: https://doi.org/10.1042/BST20201067
Published: 10 June 2021
View article titled, Biological insights from SMA-extracted proteins
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Articles

New insights into promoter–enhancer communication mechanisms revealed by dynamic single-molecule imaging

Jieru Li, Alexandros Pertsinidis
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1299–1309.
DOI: https://doi.org/10.1042/BST20200963
Published: 01 June 2021
View article titled, New insights into promoter–enhancer communication mechanisms revealed by dynamic single-molecule imaging
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Articles

Methodology to detect oxidised phospholipids and their relevance in disease

Ahilanandan Dushianthan, Anthony Postle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1241–1250.
DOI: https://doi.org/10.1042/BST20200852
Published: 07 May 2021
View article titled, Methodology to detect oxidised phospholipids and their relevance in disease
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Articles

What's in a mass?

Juan J. Calvete, Libia Sanz, Diana Mora-Obando, Bruno Lomonte, Anita M. Tanaka-Azevedo, Karen de Morais-Zani, Sávio S. Sant'Anna, Cleópatra A.S. Caldeira
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 1027–1037.
DOI: https://doi.org/10.1042/BST20210288
Published: 30 April 2021
View article titled, What's in a mass?
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Articles

Chemical reporters to study mammalian O-glycosylation

Kathryn E. Huxley, Lianne I. Willems
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 903–913.
DOI: https://doi.org/10.1042/BST20200839
Published: 16 April 2021
View article titled, Chemical reporters to study mammalian O-glycosylation
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Articles

Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes

Francesca De Giorgi, Marco Fumagalli, Luigi Scietti, Federico Forneris
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 855–866.
DOI: https://doi.org/10.1042/BST20200767
Published: 11 March 2021
View article titled, Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes
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Articles

Advances in modelling the human microbiome–gut–brain axis in vitro

Chrysanthi-Maria Moysidou, Róisín M. Owens
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 187–201.
DOI: https://doi.org/10.1042/BST20200338
Published: 05 February 2021
View article titled, Advances in modelling the human microbiome–gut–brain axis in vitro
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Articles

The search for RNA-binding proteins: a technical and interdisciplinary challenge

Jeffrey M. Smith, Jarrod J. Sandow, Andrew I. Webb
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 393–403.
DOI: https://doi.org/10.1042/BST20200688
Published: 25 January 2021
View article titled, The search for RNA-binding proteins: a technical and interdisciplinary challenge
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Articles

A mass spectrometry-based glycotope-centric cellular glycomics is the more fruitful way forward to see the forest for the trees

Kay-Hooi Khoo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 55–69.
DOI: https://doi.org/10.1042/BST20190861
Published: 25 January 2021
View article titled, A mass spectrometry-based glycotope-centric cellular glycomics is the more fruitful way forward to see the forest for the trees
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Articles

Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors

Asal Ghaffari Zaki, Yusuf C. Erdoğan, Tuba Akgul Caglar, Emrah Eroglu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 335–345.
DOI: https://doi.org/10.1042/BST20210506
Published: 11 January 2021
View article titled, Chemogenetic approaches to dissect the role of H 2 O 2 in redox-dependent pathways using genetically encoded biosensors
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Articles

Nuclear import of histones

Natalia Elisa Bernardes, Yuh Min Chook
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2753–2767.
DOI: https://doi.org/10.1042/BST20200572
Published: 10 December 2020
View article titled, Nuclear import of histones
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Articles

Engineering with NanoLuc: a playground for the development of bioluminescent protein switches and sensors

Lieuwe Biewenga, Bas J.H.M. Rosier, Maarten Merkx
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2643–2655.
DOI: https://doi.org/10.1042/BST20200440
Published: 26 November 2020
View article titled, Engineering with NanoLuc: a playground for the development of bioluminescent protein switches and sensors
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Articles

Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications

In Collection
Coronavirus
Jiayue-Clara Jiang, Yan Zhang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2851–2863.
DOI: https://doi.org/10.1042/BST20200744
Published: 10 November 2020
View article titled, Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications
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