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Articles

Chemical catalysis by biological amyloids

Pernilla Wittung-Stafshede
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230617.
https://doi.org/10.1042/BST20230617
Published: 25 September 2023
View article titled, Chemical catalysis by biological amyloids
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Articles

Mitophagy-promoting agents and their ability to promote healthy-aging

Vijigisha Srivastava, Einav Gross
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221363.
https://doi.org/10.1042/BST20221363
Published: 31 August 2023
View article titled, Mitophagy-promoting agents and their ability to promote healthy-aging
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Articles

γ-Secretase fanning the fire of innate immunity

Chenge Liu, Cyrus Nikain, Yue-Ming Li
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1597–1610.
https://doi.org/10.1042/BST20221445
Published: 14 July 2023
View article titled, γ-Secretase fanning the fire of innate immunity
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Articles

Epitranscriptomics: new players in an old game

Alba Coego, Helena Covelo-Molares, Diana Guallar
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 783–796.
https://doi.org/10.1042/BST20221417
Published: 04 April 2023
View article titled, Epitranscriptomics: new players in an old game
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Articles

Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?

Giada Zanini, Valentina Selleri, Sandra Lopez Domenech, Mara Malerba, Milena Nasi, Anna Vittoria Mattioli, Marcello Pinti
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 735–745.
https://doi.org/10.1042/BST20221010
Published: 04 April 2023
View article titled, Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system?
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Articles

Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling

Tahir Muhammad, Jian Li
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 501–512.
https://doi.org/10.1042/BST20220616
Published: 09 March 2023
View article titled, Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling
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Articles

Mitochondrial DNA in cell death and inflammation

In Collection
Cell death and survival
Rosalie Heilig, Jordan Lee, Stephen W.G. Tait
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 457–472.
https://doi.org/10.1042/BST20221525
Published: 23 February 2023
View article titled, Mitochondrial DNA in cell death and inflammation
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Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Safak Er, Mikko Airavaara
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 245–257.
https://doi.org/10.1042/BST20220770
Published: 16 February 2023
View article titled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease
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Articles

The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration

Rima Budvytyte, Gintaras Valincius
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 147–159.
https://doi.org/10.1042/BST20220434
Published: 11 January 2023
View article titled, The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration
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Articles

Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms

Feixiang Bao, Lingyan Zhou, Jiahui Xiao, Xingguo Liu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1773–1783.
https://doi.org/10.1042/BST20220726
Published: 09 December 2022
View article titled, Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms
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Articles

The role of UV-DDB in processing 8-oxoguanine during base excision repair

Ashna Nagpal, Sripriya Raja, Bennett Van Houten
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1481–1488.
https://doi.org/10.1042/BST20220748
Published: 28 October 2022
View article titled, The role of UV-DDB in processing 8-oxoguanine during base excision repair
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Articles

Fundamental roles for inter-organelle communication in aging

Eric K. F. Donahue, Elizabeth M. Ruark, Kristopher Burkewitz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1389–1402.
https://doi.org/10.1042/BST20220519
Published: 28 October 2022
View article titled, Fundamental roles for inter-organelle communication in aging
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Articles

Spatial sequestration of misfolded proteins in neurodegenerative diseases

Sarah Rolli, Emily Mitchell Sontag
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 759–771.
https://doi.org/10.1042/BST20210862
Published: 21 March 2022
View article titled, Spatial sequestration of misfolded proteins in neurodegenerative diseases
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Articles

Translational control in cell ageing: an update

Katrina Woodward, Nikolay E. Shirokikh
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2853–2869.
https://doi.org/10.1042/BST20210844
Published: 16 December 2021
View article titled, Translational control in cell ageing: an update
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Articles

Insights into neurodegeneration from electron microscopy studies

R. Anthony Crowther
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2777–2786.
https://doi.org/10.1042/BST20210719
Published: 23 November 2021
View article titled, Insights into neurodegeneration from electron microscopy studies
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Articles

LRRK2 along the Golgi and lysosome connection: a jamming situation

Giovanni Piccoli, Mattia Volta
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2063–2072.
https://doi.org/10.1042/BST20201146
Published: 08 September 2021
View article titled, LRRK2 along the Golgi and lysosome connection: a jamming situation
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Articles

Heterochromatin and Polycomb as regulators of haematopoiesis

Christine R. Keenan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 805–814.
https://doi.org/10.1042/BST20200737
Published: 30 April 2021
View article titled, Heterochromatin and Polycomb as regulators of haematopoiesis
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Articles

Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms

Márcio Simão, M. Leonor Cancela
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 747–759.
https://doi.org/10.1042/BST20200672
Published: 30 April 2021
View article titled, Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms
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Articles

Serpins in cartilage and osteoarthritis: what do we know?

David J. Wilkinson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 1013–1026.
https://doi.org/10.1042/BST20201231
Published: 12 April 2021
View article titled, Serpins in cartilage and osteoarthritis: what do we know?
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Articles

The regulation of the DNA damage response at telomeres: focus on kinases

Michela Galli, Chiara Frigerio, Maria Pia Longhese, Michela Clerici
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 933–943.
https://doi.org/10.1042/BST20200856
Published: 26 March 2021
View article titled, The regulation of the DNA damage response at telomeres: focus on kinases
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Articles

New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics

Crisdion Krstevski, Charles D. Cohen, Malathi S.I. Dona, Alexander R. Pinto
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2483–2493.
https://doi.org/10.1042/BST20191255
Published: 01 December 2020
View article titled, New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics
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Articles

Post-transcriptional control of mitochondrial protein composition in changing environmental conditions

Tatsuhisa Tsuboi, Jordan Leff, Brian M. Zid
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2565–2578.
https://doi.org/10.1042/BST20200250
Published: 27 November 2020
View article titled, Post-transcriptional control of mitochondrial protein composition in changing environmental conditions
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Articles

Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications

Lindsay K. Pino, Jacob Rose, Amy O'Broin, Samah Shah, Birgit Schilling
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1953–1966.
https://doi.org/10.1042/BST20191091
Published: 20 October 2020
View article titled, Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications
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Articles

Advances in the occurrence and biotherapy of osteoporosis

Zi Zou, Wei Liu, Lihua Cao, Ying Liu, Tiantian He, Shuping Peng, Cijun Shuai
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1623–1636.
https://doi.org/10.1042/BST20200005
Published: 06 July 2020
View article titled, Advances in the occurrence and biotherapy of osteoporosis
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Articles

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson–Gilford progeria (HGPS)

Oliver Dreesen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 981–991.
https://doi.org/10.1042/BST20190882
Published: 15 June 2020
View article titled, Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson–Gilford progeria (HGPS)
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Articles

Hydrogen peroxide reactivity and specificity in thiol-based cell signalling

Christine C. Winterbourn
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 745–754.
https://doi.org/10.1042/BST20190049
Published: 15 May 2020
View article titled, Hydrogen peroxide reactivity and specificity in thiol-based cell signalling
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Articles

Functional heterogeneity in senescence

Kristina Kirschner, Nattaphong Rattanavirotkul, Megan F. Quince, Tamir Chandra
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 765–773.
https://doi.org/10.1042/BST20190109
Published: 05 May 2020
View article titled, Functional heterogeneity in senescence
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Articles

Cross-talk between redox signalling and protein aggregation

Loes van Dam, Tobias B. Dansen
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 379–397.
https://doi.org/10.1042/BST20190054
Published: 20 April 2020
View article titled, Cross-talk between redox signalling and protein aggregation
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Articles

Redox signalling and ageing: insights from Drosophila

Claudia Lennicke, Helena M. Cochemé
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 367–377.
https://doi.org/10.1042/BST20190052
Published: 20 March 2020
View article titled, Redox signalling and ageing: insights from Drosophila
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Articles

The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology

Cerrone R. Foster, Shiho Satomi, Yuko Kato, Hemal H. Patel
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 165–177.
https://doi.org/10.1042/BST20190388
Published: 03 February 2020
View article titled, The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology
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Articles

Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches

Amy J. Tibbo, Gonzalo S. Tejeda, George S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1557–1565.
https://doi.org/10.1042/BST20190763
Published: 23 October 2019
View article titled, Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches
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Articles

Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes

Mark A. Watson, Hoi-Shan Wong, Martin D. Brand
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1461–1469.
https://doi.org/10.1042/BST20190305
Published: 10 September 2019
View article titled, Use of S1QELs and S3QELs to link mitochondrial sites of superoxide and hydrogen peroxide generation to physiological and pathological outcomes
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Articles

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald, Katy Barnes, Christopher Hastings, Heather Mortiboys
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 891–909.
https://doi.org/10.1042/BST20170501
Published: 19 July 2018
View article titled, Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?
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Articles

Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans

Francis B. Stephens, Kostas Tsintzas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 111–118.
https://doi.org/10.1042/BST20170198
Published: 12 January 2018
View article titled, Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans
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Articles

Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome

Charlotte Strandgren, Gwladys Revêchon, Agustín Sola Carvajal, Maria Eriksson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1279–1293.
https://doi.org/10.1042/BST20170141
Published: 10 November 2017
View article titled, Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome
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Articles

LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis

Mattia Volta, Heather Melrose
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 113–122.
https://doi.org/10.1042/BST20160238
Published: 15 February 2017
View article titled, LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis
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Articles

The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Claudia Manzoni
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 155–162.
https://doi.org/10.1042/BST20160265
Published: 15 February 2017
View article titled, The LRRK2–macroautophagy axis and its relevance to Parkinson's disease
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Articles

LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?

Jean-Marc Taymans, Eugénie Mutez, Matthieu Drouyer, William Sibran, Marie-Christine Chartier-Harlin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 207–212.
https://doi.org/10.1042/BST20160334
Published: 15 February 2017
View article titled, LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?
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Articles

Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes

Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio Jesús Lara Ordóñez, Marian Blanca Ramírez, María Romo Lozano, Pilar Rivero-Ríos, Sabine Hilfiker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 147–154.
https://doi.org/10.1042/BST20160392
Published: 15 February 2017
View article titled, Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes
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Articles

LRRK2: from kinase to GTPase to microtubules and back

Marian Blanca Ramírez, Antonio Jesús Lara Ordóñez, Elena Fdez, Sabine Hilfiker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 141–146.
https://doi.org/10.1042/BST20160333
Published: 15 February 2017
View article titled, LRRK2: from kinase to GTPase to microtubules and back
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Articles

Structural insights into functional amyloid inhibition in Gram −ve bacteria

William Hawthorne, Sarah Rouse, Lee Sewell, Stephen J. Matthews
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1643–1649.
https://doi.org/10.1042/BST20160245
Published: 02 December 2016
View article titled, Structural insights into functional amyloid inhibition in Gram −ve bacteria
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Articles

Translational regulation of mitochondrial biogenesis

Yi Zhang, Hong Xu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1717–1724.
https://doi.org/10.1042/BST20160071C
Published: 02 December 2016
View article titled, Translational regulation of mitochondrial biogenesis
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Articles

The quantum mitochondrion and optimal health

Alistair V.W. Nunn, Geoffrey W. Guy, Jimmy D. Bell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1101–1110.
https://doi.org/10.1042/BST20160096
Published: 15 August 2016
View article titled, The quantum mitochondrion and optimal health
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