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Articles

SYNBIOCHEM–a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Pablo Carbonell, Andrew Currin, Mark Dunstan, Donal Fellows, Adrian Jervis, Nicholas J.W. Rattray, Christopher J. Robinson, Neil Swainston, Maria Vinaixa, Alan Williams, Cunyu Yan, Perdita Barran, Rainer Breitling, George Guo-Qiang Chen, Jean-Loup Faulon, Carole Goble, Royston Goodacre, Douglas B. Kell, Rosalind Le Feuvre, Jason Micklefield, Nigel S. Scrutton, Philip Shapira, Eriko Takano, Nicholas J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 675–677.
DOI: https://doi.org/10.1042/BST20160009
Published: 09 June 2016
View article titled, SYNBIOCHEM–a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals
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Articles

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides

S. Abes, H. Moulton, J. Turner, P. Clair, J.P. Richard, P. Iversen, M.J. Gait, B. Lebleu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 53–55.
DOI: https://doi.org/10.1042/BST0350053
Published: 22 January 2007
View article titled, Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides
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Articles

Proteolytic processing of the amyloid precursor protein by α-secretase

T. M. J. Allinson, A. J. Turner, N. M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (3): A78.
DOI: https://doi.org/10.1042/bst030a078b
Published: 01 June 2002
View article titled, Proteolytic processing of the amyloid precursor protein by α-secretase
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Articles

Altered processing of the Alzheimer's amyloid precursor protein in human neuroblastoma cells expressing the prion protein

E. T. Parkin, A. J. Turner, N. M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (3): A79.
DOI: https://doi.org/10.1042/bst030a079
Published: 01 June 2002
View article titled, Altered processing of the Alzheimer's amyloid precursor protein in human neuroblastoma cells expressing the prion protein
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Articles

A Novel Human Homologue of Angiotensin-Converting Enzyme

S. R. Tipnis, G. Christie, A. J. Turner, N. M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (5): A322.
DOI: https://doi.org/10.1042/bst028a322a
Published: 01 October 2000
View article titled, A Novel Human Homologue of Angiotensin-Converting Enzyme
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Articles

CHARACTERISATION OF THE ENDOPROTEOLYTIC CLEAVAGE OF THE FAMILIAL ALZHEIMER'S DISEASE PROTEIN PRESENILIN-1

C. H. Lindley, A. J. Turner, J. Davis, N. M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (5): A305.
DOI: https://doi.org/10.1042/bst028a305c
Published: 01 October 2000
View article titled, CHARACTERISATION OF THE ENDOPROTEOLYTIC CLEAVAGE OF THE FAMILIAL ALZHEIMER'S DISEASE PROTEIN PRESENILIN-1
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Articles

The Alzheimer's amyloid precursor protein α-secretase and the angiotensin converting enzyme secretase exhibit closely related enzyme activities

E. T. Parkin, A. J. Turner, N. M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (5): A306.
DOI: https://doi.org/10.1042/bst028a306b
Published: 01 October 2000
View article titled, The Alzheimer's amyloid precursor protein α-secretase and the angiotensin converting enzyme secretase exhibit closely related enzyme activities
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Articles

The cloning and characterisation of human soluble X-prolyl aminopeptidase (aminopeptidase P)

G. S. Cottrell, N. M. Hooper, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (5): A309.
DOI: https://doi.org/10.1042/bst028a309a
Published: 01 October 2000
View article titled, The cloning and characterisation of human soluble X-prolyl aminopeptidase (aminopeptidase P)
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Articles

EFFECT OF CHOLINERGIC AGONISTS ON SECRETION OF ACETYLCHOLINESTERASE BY HUMAN NEUROBLASTOMA SH-SY5Y CELLS

N. N. Nalivaeva, A. J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (5): A353.
DOI: https://doi.org/10.1042/bst028a353b
Published: 01 October 2000
View article titled, EFFECT OF CHOLINERGIC AGONISTS ON SECRETION OF ACETYLCHOLINESTERASE BY HUMAN NEUROBLASTOMA SH-SY5Y CELLS
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Articles

Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease

N. M. Hooper, A. J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (4): 441–446.
DOI: https://doi.org/10.1042/bst0280441
Published: 01 August 2000
View article titled, Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease
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Articles

Cloning and characterisation of human cytosolic aminopeptidase P

Graeme S. Cottrell, Nigel M. Hooper, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (3): A84.
DOI: https://doi.org/10.1042/bst028a084a
Published: 01 June 2000
View article titled, Cloning and characterisation of human cytosolic aminopeptidase P
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Articles

Regulation of the isoforms of brain and endothelial endothelin converting enzyme-1

Kay Barnes, Julie A. Carson, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (3): A81.
DOI: https://doi.org/10.1042/bst028a081a
Published: 01 June 2000
View article titled, Regulation of the isoforms of brain and endothelial endothelin converting enzyme-1
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Articles

Identification and Characterisation of a Novel Human Zinc Metalloprotease with Homology to Angiotensin Converting Enzyme

Sarah R. Tipnis, Nigel M. Hooper, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (3): A81.
DOI: https://doi.org/10.1042/bst028a081b
Published: 01 June 2000
View article titled, Identification and Characterisation of a Novel Human Zinc Metalloprotease with Homology to Angiotensin Converting Enzyme
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Articles

REGULATION OF sAPPα SECRETION BY MUSCARINE IN THE HUMAN NEUROBLASTOMA CELL LINE SH-SY5Y

ROSA M. CANET-AVILES, ANTHONY J. TURNER, NIGEL M. HOOPER, PETER F.T. VAUGHAN
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (1): A33.
DOI: https://doi.org/10.1042/bst028a033b
Published: 01 February 2000
View article titled, REGULATION OF sAPPα SECRETION BY MUSCARINE IN THE HUMAN NEUROBLASTOMA CELL LINE SH-SY5Y
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Articles

A role for ADAMs proteinases as membrane protein secretases

Anthony J. Turner, Nigel M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (1): A24.
DOI: https://doi.org/10.1042/bst027a024b
Published: 01 February 1999
View article titled, A role for ADAMs proteinases as membrane protein secretases
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Articles

Angiotensin converting enzyme and the amyloid precursor protein secretases

Nigel M. Hooper, S. Parvathy, Eric H. Karran, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (1): A23.
DOI: https://doi.org/10.1042/bst027a023b
Published: 01 February 1999
View article titled, Angiotensin converting enzyme and the amyloid precursor protein secretases
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Articles

Role for ADAM-family proteinases as membrane protein secretases

Anthony J. Turner, Nigel M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (2): 255–260.
DOI: https://doi.org/10.1042/bst0270255
Published: 01 February 1999
View article titled, Role for ADAM-family proteinases as membrane protein secretases
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Articles

Angiotensin-converting enzyme and the amyloid precursor protein secretases

N. M. Hooper, S. Parvathy, E. H. Karran, A. J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1999) 27 (2): 229–234.
DOI: https://doi.org/10.1042/bst0270229
Published: 01 February 1999
View article titled, Angiotensin-converting enzyme and the amyloid precursor protein secretases
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Articles

Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins

EDWARD T. PARKIN, ANTHONY J. TURNER, NIGEL M. HOOPER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1998) 26 (3): S241.
DOI: https://doi.org/10.1042/bst026s241
Published: 01 August 1998
View article titled, Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins
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Articles

The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors

S. Parvathy, Ishrut Hussain, Eric H. Karran, Anthony J. Turner, Nigel M. Hooper
Journal: Biochemical Society Transactions
Biochem Soc Trans (1998) 26 (3): S242.
DOI: https://doi.org/10.1042/bst026s242
Published: 01 August 1998
View article titled, The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors
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Articles

Molecular characterisation of the alzheimer's amyloid precursor protein secretases

Sarah L. Houldsworth, Alison J. Trew, Nigel M. Hooper, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1998) 26 (3): S245.
DOI: https://doi.org/10.1042/bst026s245
Published: 01 August 1998
View article titled, Molecular characterisation of the alzheimer's amyloid precursor protein secretases
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Articles

The cloning and functional expression of human pancreatic aminopeptidase P

Graeme S. Cottrell, Ralph J. Hyde, Nigel M. Hooper, Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1998) 26 (3): S248.
DOI: https://doi.org/10.1042/bst026s248
Published: 01 August 1998
View article titled, The cloning and functional expression of human pancreatic aminopeptidase P
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Articles

Stimulation of tyrosine phosphorylation and phosphatidylinositol 3-kinase by MCP-1 in THP-1 cells

SARAH J. TURNER, STEPHEN G. WARD, JOHN WESTWICK
Journal: Biochemical Society Transactions
Biochem Soc Trans (1997) 25 (2): 216S.
DOI: https://doi.org/10.1042/bst025216s
Published: 01 May 1997
View article titled, Stimulation of tyrosine phosphorylation and phosphatidylinositol 3-kinase by MCP-1 in THP-1 cells
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Articles

A role for calcium and annexins in the formation of caveolae

EDWARD T. PARKIN, ANTHONY J. TURNER, NIGEL M. HOOPER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1996) 24 (3): 444S.
DOI: https://doi.org/10.1042/bst024444s
Published: 01 August 1996
View article titled, A role for calcium and annexins in the formation of caveolae
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Articles

Cloning and functional expression of pig kidney aminopeptidase P

RALPH J. HYDE, NIGEL M. HOOPER, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1996) 24 (3): 470S.
DOI: https://doi.org/10.1042/bst024470s
Published: 01 August 1996
View article titled, Cloning and functional expression of pig kidney aminopeptidase P
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Articles

Mutagenesis and modelling of endothelin converting enzyme

V. M. HOANG, C. E. SANSOM, A. J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1996) 24 (3): 471S.
DOI: https://doi.org/10.1042/bst024471s
Published: 01 August 1996
View article titled, Mutagenesis and modelling of endothelin converting enzyme
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Articles

Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells

Sarah J. Turner, Stephen G. Ward, Murray McKinnon, John Westwick
Journal: Biochemical Society Transactions
Biochem Soc Trans (1996) 24 (1): 69S.
DOI: https://doi.org/10.1042/bst024069s
Published: 01 February 1996
View article titled, Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells
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Articles

Chemical modification of aminopeptidase P: Identification of a critical histidyl residue

JAESEUNG LIM, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (4): 549S.
DOI: https://doi.org/10.1042/bst023549s
Published: 01 November 1995
View article titled, Chemical modification of aminopeptidase P: Identification of a critical histidyl residue
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Articles

Purification and characterization of the angiotensin converting enzyme secretase

CAROLINE CONNOLLY, SYLVESTER Y. OPPONG, ANTHONY J. TURNER, NIGEL M. HOOPER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (4): 551S.
DOI: https://doi.org/10.1042/bst023551s
Published: 01 November 1995
View article titled, Purification and characterization of the angiotensin converting enzyme secretase
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Articles

Identification of the site of cleavage in angiotensin converting enzyme by its secretase

NIGEL M. HOOPER, SYLVESTER Y. OPPONG, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (4): 552S.
DOI: https://doi.org/10.1042/bst023552s
Published: 01 November 1995
View article titled, Identification of the site of cleavage in angiotensin converting enzyme by its secretase
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Articles

Peptidase content of the bile canalicular membrane

KATHERINE A. ZUZEL, JOHN G. GRAHAM, JOHN HRYSZKO, DAVID BILLINGTON, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (2): 306S.
DOI: https://doi.org/10.1042/bst023306s
Published: 01 May 1995
View article titled, Peptidase content of the bile canalicular membrane
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Articles

Aminopeptidase P: Cation activation and inhibitor sensitivity are substrate-dependent

GEORGINA S. LLOYD, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1995) 23 (1): 60S.
DOI: https://doi.org/10.1042/bst023060s
Published: 01 February 1995
View article titled, Aminopeptidase P: Cation activation and inhibitor sensitivity are substrate-dependent
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Articles

MOLECULAR CLONING OF ENDOPEPTIDASE-24.15 FROM PIG BRAIN

Nicolette Habgood, Helen Eastham, Anthony J Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1994) 22 (4): 415S.
DOI: https://doi.org/10.1042/bst022415s
Published: 01 November 1994
View article titled, MOLECULAR CLONING OF ENDOPEPTIDASE-24.15 FROM PIG BRAIN
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Articles

IMMUNOSEPARATION OF MEMBRANE PEPTIDASES FROM PIG LUNG MEMBRANES USING MAGNETIC BEADS

Kay Barnes, Leonard J Murphy, Anthony J Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1994) 22 (4): 451S.
DOI: https://doi.org/10.1042/bst022451s
Published: 01 November 1994
View article titled, IMMUNOSEPARATION OF MEMBRANE PEPTIDASES FROM PIG LUNG MEMBRANES USING MAGNETIC BEADS
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Articles

Membrane peptidase activity of a human endothelial cell line (EA.hy 926)

KATHERINE J GREENHOUGH, BRENDAN J WALKDEN, LEONARD J MURPHY, HAZEL E McLAREN, KAY BARNES, ANTHONY J TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1994) 22 (4): 454S.
DOI: https://doi.org/10.1042/bst022454s
Published: 01 November 1994
View article titled, Membrane peptidase activity of a human endothelial cell line (EA.hy 926)
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Articles

Characterisation of human adenosine type 1, 2a and 2b receptors expressed in CHO cells

PHLIPPA J ROLLINS, SARAH J TURNER, CAROLINE I O AKPOGUMA, KEITH P RAY
Journal: Biochemical Society Transactions
Biochem Soc Trans (1994) 22 (2): 195S.
DOI: https://doi.org/10.1042/bst022195s
Published: 01 May 1994
View article titled, Characterisation of human adenosine type 1, 2a and 2b receptors expressed in CHO cells
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Articles

Neuropeptidases: candidate enzymes and techniques for study

Anthony J. Turner, Kay Barnes
Journal: Biochemical Society Transactions
Biochem Soc Trans (1994) 22 (1): 122–127.
DOI: https://doi.org/10.1042/bst0220122
Published: 01 February 1994
View article titled, Neuropeptidases: candidate enzymes and techniques for study
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Articles

Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme

SYLVESTER Y. OPPONG, ANTHONY J. TURNER, NIGEL M. HOOPER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 251S.
DOI: https://doi.org/10.1042/bst021251s
Published: 01 August 1993
View article titled, Characterization of the soluble and membrane-bound forms of porcine angiotensin converting enzyme
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Articles

Membrane peptidase expression by confluent cultures of Caco-2 cells

IAN A. BREWIS, STEVEN HOWELL, NIGEL M. HOOPER, A. JOHN KENNY, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 252S.
DOI: https://doi.org/10.1042/bst021252s
Published: 01 August 1993
View article titled, Membrane peptidase expression by confluent cultures of Caco-2 cells
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Articles

Aminopeptidase P: Immunoaffinity purification and molecular characterisation

GEORGINA S. LLOYD, NICOLETTE T. HABGOOD, NIGEL M. HOOPER, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 236S.
DOI: https://doi.org/10.1042/bst021236s
Published: 01 August 1993
View article titled, Aminopeptidase P: Immunoaffinity purification and molecular characterisation
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Articles

Chemical modification of n-Methyl-d-Aspartate receptors from pig brain

CAROLINE T. CRILLEY, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 271S.
DOI: https://doi.org/10.1042/bst021271s
Published: 01 August 1993
View article titled, Chemical modification of n-Methyl-d-Aspartate receptors from pig brain
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Articles

Endothelin-converting enzymes and other families of metallo-endopeptidases

Anthony J. Turner
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 697–702.
DOI: https://doi.org/10.1042/bst0210697
Published: 01 August 1993
View article titled, Endothelin-converting enzymes and other families of metallo-endopeptidases
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Articles

Co-localisation of substance P and endopeptidase-24.11 in pig substantia nigra: an ultrastructural study

KAY BARNES, ANTHONY J TURNER, A. JOHN KENNY
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 246S.
DOI: https://doi.org/10.1042/bst021246s
Published: 01 August 1993
View article titled, Co-localisation of substance P and endopeptidase-24.11 in pig substantia nigra: an ultrastructural study
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Articles

Hydrolysis of cholecystokinin by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y

MARGARET DOS SANTOS MEDEIROS, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 247S.
DOI: https://doi.org/10.1042/bst021247s
Published: 01 August 1993
View article titled, Hydrolysis of cholecystokinin by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y
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Articles

Processing and metabolism of peptide YY

MARGARET DOS SANTOS MEDEIROS, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (3): 248S.
DOI: https://doi.org/10.1042/bst021248s
Published: 01 August 1993
View article titled, Processing and metabolism of peptide YY
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Articles

Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases

IAN A. BREWIS, MICHAEL A. J. FERGUSON, ANTHONY J. TURNER, NIGEL M. HOOPER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (1): 46S.
DOI: https://doi.org/10.1042/bst021046s
Published: 01 February 1993
View article titled, Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases
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Articles

Endothelin converting enzyme of porcine lung

LEONARD J. MURPHY, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (1): 27S.
DOI: https://doi.org/10.1042/bst021027s
Published: 01 February 1993
View article titled, Endothelin converting enzyme of porcine lung
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Articles

Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase

IAN A. BREWIS, NIGEL M. HOOPER, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1993) 21 (1): 44S.
DOI: https://doi.org/10.1042/bst021044s
Published: 01 February 1993
View article titled, Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase
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Articles

The regulation of endopeptidase-24.11 expression on human osteoblast-like cells in culture

STEVEN HOWELL, ALISON M. CASWELL, A. JOHN KENNY, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (3): 282S.
DOI: https://doi.org/10.1042/bst020282s
Published: 01 August 1992
View article titled, The regulation of endopeptidase-24.11 expression on human osteoblast-like cells in culture
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Articles

Immunological studies on the endothelial and testicular forms of angiotensin converting enzyme

TRACY A. WILLIAMS, NIGEL M. HOOPER, KAY BARNES, A. JOHN KENNY, ANTHONY J. TURNER
Journal: Biochemical Society Transactions
Biochem Soc Trans (1992) 20 (3): 281S.
DOI: https://doi.org/10.1042/bst020281s
Published: 01 August 1992
View article titled, Immunological studies on the endothelial and testicular forms of angiotensin converting enzyme
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