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Investigation of electrostatic and hydrogen bonding interactions of caricain and caricain D158N with time-dependent inhibitors

SYEED HUSSAIN, KIMBERLEY K. ALLEN, IAN F. CONNERTON, NICOLA J. CUMMINGS, SHERAZ GUL, AKAVISH KHAN, MARK A.J. TAYLOR, EMRYS W. THOMAS, CHANDRA VERMA, KEITH BROCKLEHURST

Biochem Soc Trans (1999) 27 (1): A37.

DOI: https://doi.org/10.1042/bst027a037a

Published: 01 February 1999

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Articles

Detection of a free enzyme isomerisation in actinidin catalysed hydrolysis

JAMES D. REID, SUNEAL SREEDHARAN, AMBROSE COLE, SCOTT MASKELL, ANJUMON BOKTH, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1998) 26 (2): S173.

DOI: https://doi.org/10.1042/bst026s173

Published: 01 May 1998

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Sensitivities of transition state geometries to P1-P2 binding in reactions of papain and actinidin

SHERAZ GUL, SURAPONG PINITGLANG, EMRYS W. THOMAS, CHANDRA VERMA, KEITH BROCKLEHURST

Biochem Soc Trans (1998) 26 (2): S171.

DOI: https://doi.org/10.1042/bst026s171

Published: 01 May 1998

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The kinetically influential ionizations of caricain D158N revealed by using 4,4′-dipyrimidyl disulfide as a reactivity probe

AKAVISH KHAN, IAN F. CONNERTON, NICOLA J. CUMMINGS, SYEED HUSSAIN, MICHAEL A. NOBLE, MARK A. J. TAYLOR, EMRYS W. THOMAS, CHANDRA VERMA, KEITH BROCKLEHURST

Biochem Soc Trans (1998) 26 (2): S172.

DOI: https://doi.org/10.1042/bst026s172

Published: 01 May 1998

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Effects of the quality of the P 2 -S 2 hydrophobic contacts on the catalytic activities of papain, caricain and ficin and their generation by electrostatic switches

SURAPONG PINITGLANG, MANIJ PATEL, MICHAEL NOBLE, SUNEAL K. SREEDHARAN, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1997) 25 (1): 88S.

DOI: https://doi.org/10.1042/bst025088s

Published: 01 February 1997

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Articles

ACTINIDIN AND CHYMOPAPAIN B PROVIDE VARIATION IN THE COMMON ELECTROSTATIC ENVIRONMENT OF GLU50 IN PAPAIN AND CARICAIN

JAMES D. REID, SURAPONG PINITGLANG, CHRISTOPHER M. TOPHAM, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1997) 25 (1): 89S.

DOI: https://doi.org/10.1042/bst025089s

Published: 01 February 1997

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Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probes

SHERAZ GUL, ANNA CLARKE, BEN FIELD, MARK P. THOMAS, FRANCES WILLENBROCK, SURAPONG PINITGLANG, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1997) 25 (1): 91S.

DOI: https://doi.org/10.1042/bst025091s

Published: 01 February 1997

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Articles

Design and synthesis of substrate-derived n-acylaminoalkyl 2-pyridyl disulphides as probes of cysteine proteinase mechanism

KEITH BROCKLEHURST, EMRYS W. THOMAS, CHANDRA VERMA, MANIJ PATEL, SUNEAL K. SREEDHARAN

Biochem Soc Trans (1997) 25 (1): 92S.

DOI: https://doi.org/10.1042/bst025092s

Published: 01 February 1997

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Articles

Effects of site-specific mutations on the kinetically influential ionizations of papain

AARON WATTS, AZHAR HAFEEZ, SHERAZ GUL, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1997) 25 (1): 84S.

DOI: https://doi.org/10.1042/bst025084s

Published: 01 February 1997

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Articles

Studies on the enhancement of the reactivity of the (Cys-25)-S - /(His159)-Im + H ion-pair of papain by deprotonation across p K a 4

SURAPONG PINITGLANG, MICHAEL NOBLE, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1996) 24 (3): 468S.

DOI: https://doi.org/10.1042/bst024468s

Published: 01 August 1996

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Investigation of electrostatic interactions and binding effects in papin-ligand interaction

SHERAZ GUL, PARAMDEEP S. DHILLON, CHANDRA VERMA, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1996) 24 (3): 473S.

DOI: https://doi.org/10.1042/bst024473s

Published: 01 August 1996

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Articles

Evidence from activation parameters for enzyme active centre desolvation promoted by specific binding interactions

GEOFFREY W. MELLOR, MARK P. THOMAS, SHERAZ GUL, MICHAEL A. NOBLE, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1994) 22 (2): 213S.

DOI: https://doi.org/10.1042/bst022213s

Published: 01 May 1994

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Variation in the effects of P 2 -S 2 binding contacts on catalytic site chemistry among members of the cysteine proteinase family

MANIJ PATEL, MARK P. THOMAS, MICHAEL A. NOBLE, SHERAZ GUL, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1994) 22 (2): 214S.

DOI: https://doi.org/10.1042/bst022214s

Published: 01 May 1994

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Existence of the Cys-His ion-pair state of cysteine proteinases may be an insufficient condition for catalytic competence

SURAPONG PINITGLANG, MANU PATEL, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1994) 22 (2): 215S.

DOI: https://doi.org/10.1042/bst022215s

Published: 01 May 1994

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New substrate-derived thiol-specific time-dependent inhibitors for the characterisation of the coupling of binding site interactions with catalytic site chemistry in the cysteine proteinases

Geoffrey W. MELLOR, Manij PATEL, Mark P. THOMAS, Devanand KOWLESSUR, Suneal K. SREEDHARAN, Emrys W. THOMAS, Keith BROCKLEHURST

Biochem Soc Trans (1993) 21 (2): 215S.

DOI: https://doi.org/10.1042/bst021215s

Published: 01 May 1993

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Articles

Ficin: a cysteine proteinase with binding site-catalytic site signalling characteristics intermediate between those of papain and actinidin

Manij PATEL, Mark P. THOMAS, Irfan S. KAYANI, Geoffrey W. MELLOR, Emrys W. THOMAS, Keith BROCKLEHURST

Biochem Soc Trans (1993) 21 (2): 216S.

DOI: https://doi.org/10.1042/bst021216s

Published: 01 May 1993

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Articles

Three-dimensional structure of a B-type chymopapain

CHRISTOPHER M. TOPHAM, JOHN OVERINGTON, MAIREAD O'DRISCOLL, ERDJAN SALIH, MARK THOMAS, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1990) 18 (5): 933–934.

DOI: https://doi.org/10.1042/bst0180933

Published: 01 October 1990

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Articles

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV)

CHRISTOPHER M. TOPHAM, JOHN OVERINGTON, MARK THOMAS, DEVANAND KOWLESSUR, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1990) 18 (5): 934–935.

DOI: https://doi.org/10.1042/bst0180934

Published: 01 October 1990

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Articles

Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods

CHRISTOPHER M. TOPHAM, JOHN OVERINGTON, DEVENAND KOWLESSUR, MARK THOMAS, EMRYS W. THOMAS, KEITH BROCKLEHURST

Biochem Soc Trans (1990) 18 (4): 579–580.

DOI: https://doi.org/10.1042/bst0180579

Published: 01 August 1990

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Articles

Dynamic aspects of molecular recognition in cysteine proteinase-ligand systems

KEITH BROCKLEHURST, EMRYS W. THOMAS, SIOBHAN QUENBY, DEVENAND KOWLESSUR, CLAIRE GOODING, WILLIAM TEMPLETON, ELIZABETH WILKIE, MANU PATEL, SUNEAL SREEDHARAN, MARK THOMAS, E. RICHARD BLYDEN

Biochem Soc Trans (1990) 18 (4): 581–582.

DOI: https://doi.org/10.1042/bst0180581

Published: 01 August 1990

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NARROW

Investigation of electrostatic and hydrogen bonding interactions of caricain and caricain D158N with time-dependent inhibitors

Detection of a free enzyme isomerisation in actinidin catalysed hydrolysis

Sensitivities of transition state geometries to P1-P2 binding in reactions of papain and actinidin

The kinetically influential ionizations of caricain D158N revealed by using 4,4′-dipyrimidyl disulfide as a reactivity probe

Effects of the quality of the P 2 -S 2 hydrophobic contacts on the catalytic activities of papain, caricain and ficin and their generation by electrostatic switches

ACTINIDIN AND CHYMOPAPAIN B PROVIDE VARIATION IN THE COMMON ELECTROSTATIC ENVIRONMENT OF GLU50 IN PAPAIN AND CARICAIN

Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probes

Design and synthesis of substrate-derived n-acylaminoalkyl 2-pyridyl disulphides as probes of cysteine proteinase mechanism

Effects of site-specific mutations on the kinetically influential ionizations of papain

Studies on the enhancement of the reactivity of the (Cys-25)-S - /(His159)-Im + H ion-pair of papain by deprotonation across p K a 4

Investigation of electrostatic interactions and binding effects in papin-ligand interaction

Evidence from activation parameters for enzyme active centre desolvation promoted by specific binding interactions

Variation in the effects of P 2 -S 2 binding contacts on catalytic site chemistry among members of the cysteine proteinase family

Existence of the Cys-His ion-pair state of cysteine proteinases may be an insufficient condition for catalytic competence

New substrate-derived thiol-specific time-dependent inhibitors for the characterisation of the coupling of binding site interactions with catalytic site chemistry in the cysteine proteinases

Ficin: a cysteine proteinase with binding site-catalytic site signalling characteristics intermediate between those of papain and actinidin

Three-dimensional structure of a B-type chymopapain

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV)

Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods

Dynamic aspects of molecular recognition in cysteine proteinase-ligand systems

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