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Editor-in-Chief: James Murphy
Keywords: Protein structure and function, protein kinases, pseudokinases, cell signalling, cell death
Biography: James is Head of the Inflammation Division at the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. He completed his PhD at the Australian National University in 2003 before undertaking postdoctoral training with Tony Pawson and Frank Sicheri at the Lunenfeld Institute (Toronto, Canada), then moving to Melbourne in 2007. He has pursued a mechanistic understanding of the roles of several pseudokinases, protein kinases, cytokines/receptors and epigenetic regulators in signal transduction, with a particular focus on MLKL, a key pseudokinase in the necroptosis cell death pathway. These studies have culminated in >100 publications to date.
Keywords: Extracellular matrix, signalling pathways, mechanotransduction, cell biology, cell cycle, 3D-cell culture, fluorescence microscopy, CRISPR screens.
Biography: Alexandre is an Assistant Professor in the Department of Biochemistry at University of São Paulo – Brazil. His research group, the e-Signal Lab, focuses on understanding the mechanisms of transduction of biochemical and mechanical signals between cells and the extracellular matrix. For this, his laboratory uses 3D cell culture models, biochemistry tools, molecular biology and various microscopy techniques. Dr. Bruni-Cardoso holds a Bachelor's degree in Biological Sciences and a PhD in Cellular and Structural Biology. He did his postdoctoral studies in breast cancer biology in the laboratory of Dr. Mina J. Bissell at Lawrence Berkeley National Laboratory (USA).
Affiliation: Walter and Eliza Hall Institute of Medical Research, Australia
Keywords: Epigenetic silencing, genetic screens, epigenomics and transcriptomics, dosage compensation, chromatin conformation, mouse models
Biography: Marnie completed her PhD with Professor Emma Whitelaw (University of Sydney), and her postdoctoral studies with Professor Douglas Hilton (WEHI). In her post-doc she identified a critical role for the novel protein Smchd1 in X inactivation and studied the role of polycomb group proteins in haematopoietic stem cell function. In 2010, Marnie established her own group working on the molecular mechanisms of epigenetic control. She is now a joint division head of the Epigenetics and Development Division at WEHI and a Viertel Senior Medical Research Fellow.
Affiliation: Southern University of Science and Technology, China
Keywords: Plant, epigenetics, gene regulation, DNA methylation, histone modification, structural biology, biochemistry
Biography: Jiamu obtained his PhD degree from Shanghai Institutes of Biochemistry and Cell Biology, China, in 2008. After 5 years post-doc training at the Memorial Sloan-Kettering Cancer Center in New York, he established his own independent research group in the Shanghai Center for Plant Stress Biology, China, in 2014. In 2019, he moved to Southern University of Science and Technology as a full Professor. His laboratory mainly focuses on the structural and biochemical studies on plant epigenetics-related proteins and protein-nucleic acid complexes.
Affiliation: University of Exeter, UK
Keywords: CryoEM and cryoET, protein structure determination, bacterial secretion systems, mitochondrial protein transport, bacteriophages
Biography: Vicki leads a research team at the Living Systems Institute, University of Exeter, UK. She combines different methods in cryo electron microscopy (cryoEM) with biochemical and biophysical techniques to understand more about the structure and function of multi-component molecular machines. Vicki obtained her PhD with Professor Ian Collinson at the University of Bristol, UK, in 2008, and then spent time as a EMBO fellow in the lab of Prof. Werner Kühlbrandt at the Max-Planck Institute of Biophysics in Frankfurt, Germany. Current work in Vicki’s lab focusses on the mechanisms of protein transport in bacteria and mitochondria, and in developing new ways of using bacteriophages to treat infection.
Clare L. Hawkins
Affiliation: University of Copenhagen, Denmark
Keywords: Oxidative stress, redox biology, inflammation, atherosclerosis, cardiovascular disease, protein oxidation, analytical biochemistry, peroxidase, reactive oxygen species
Biography: Clare is a Professor with Special Responsibilities in Oxidant Biology at the University of Copenhagen, appointed in March 2017 after nearly 20 years in Sydney Australia, where she held the positions of Scientific Director and Group Leader at the Heart Research Institute (HRI), and Principal Research Fellow within the Faculty of Medicine, University of Sydney. She joined the HRI in 1997 as a postdoctoral fellow after the completion of her PhD at the University of York (UK). Her research focuses on understanding the fundamental mechanisms by which oxidative stress drives cellular damage and disease development during chronic inflammation.
Ivan Robert Nabi
Affiliation: University of British Columbia, Canada
Keywords: Cancer, cell biology, caveolin, galectin, Gp78, endoplasmic reticulum, membrane domains, ER-mitochondria contacts, super-resolution microscopy, tumour metastasis, focal adhesions, cell migration
Biography: Robert is Full Professor and Director of Imaging in the Life Sciences Institute of the University of British Columbia in Vancouver, Canada. He has over 20 years of experience in cancer cell biology and have published numerous research articles and reviews in the field of cellular domains and their role in cancer progression and metastasis. Recent work has focused on super-resolution microscopy, studying the nanodomain structure of the peripheral ER, defining distinct ER-mitochondria contact sites and applying computational machine learning approaches to single molecule localization microscopy to decipher the molecular structure of caveolae and scaffolds.
Affiliation: University of Canterbury, New Zealand
Keywords: Protein structure, plant biochemistry, biophysics, photosynthesis, enzyme kinetics, protein interactions
Biography: Grant is a Principal Investigator at the Biomolecular Interactions Centre, University of Canterbury, Christchurch, New Zealand. He completed his PhD with John Andrews (Australian National University) and completed postdoctoral work with (Dame) Juliet Gerrard at the University of Canterbury. His research investigates interactions of different proteins, with particular interest in plant biochemical pathways such as photosynthesis and amino acid biosynthesis. A particular focus has been the evolution of quaternary structure, and the changes in thermostability associated with this. Much of the research utilises different methods for studying protein interactions, including scattering techniques and analytical ultracentrifugation.
Affiliation: Stellenbosch University, South Africa
Keywords: Systems biology; computational biology; kinetic modelling; plant and microbial systems; metabolic regulation
Biography: Johann Rohwer is Professor of Systems Biology in the Department of Biochemistry at Stellenbosch University. He completed his PhD with Professor Hans Westerhoff (University of Amsterdam) in 1997. His research interests are the development of software tools and equations for computational systems biology, enzyme kinetics for systems biology, and the development of kinetic models of various plant and microbial systems. He spent two stints as visiting researcher on an Alexander von Humboldt Research Fellowship at the Max Planck Institute of Molecular Plant Physiology (Potsdam-Golm) in 2008, and the Max Planck institute for Chemical Ecology (Jena) in 2016. From 2015-2019 he served as HOD of the Biochemistry Department at Stellenbosch.
Affiliation: Swedish University of Agricultural Sciences, Sweden
Keywords: Nuclear structure, Transcription traffic control, RNA polymerases, Polycomb
Biography: Stefanie did her PhD in the laboratory of Prof. Peter Shaw (JIC, UK), where she questioned how the physical properties of chromatin change during cell differentiation. In 2013, she joined the lab of Prof. Caroline Dean (JIC, UK). During this time, she used live-cell imaging approaches and single-molecule RNA detection methods to study the importance of nuclear organization and long non-coding RNAs for transcriptional regulation. In 2018, Stefanie established her independent research group in the Department of Plant Biology (SLU, Uppsala - Sweden). There, she continues her focus on using single-molecule tools to study how the spatial-temporal organization of the chromatin affects regulatory processes at the level of transcription, but also how it impacts genome stability and DNA repair mechanisms in Arabidopsis thaliana.