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Issues
February 2022
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Cover Image
Cover Image
The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
ISSN 0300-5127
EISSN 1470-8752
In this Issue
Review Articles
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
Biochem Soc Trans (2022) 50 (1): 1–11.
Role of macrophage extracellular traps in innate immunity and inflammatory disease
Biochem Soc Trans (2022) 50 (1): 21–32.
Three-dimensional insights into human enveloped viruses in vitro and in situ
Biochem Soc Trans (2022) 50 (1): 95–105.
The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation
Biochem Soc Trans (2022) 50 (1): 107–118.
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
Biochem Soc Trans (2022) 50 (1): 151–165.
Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin
Biochem Soc Trans (2022) 50 (1): 199–212.
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)
Biochem Soc Trans (2022) 50 (1): 241–252.
Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation
Biochem Soc Trans (2022) 50 (1): 269–281.
Control of non-productive RNA polymerase II transcription via its early termination in metazoans
Biochem Soc Trans (2022) 50 (1): 283–295.
Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data
Biochem Soc Trans (2022) 50 (1): 297–308.
Multiple roles of Pol epsilon in eukaryotic chromosome replication
Biochem Soc Trans (2022) 50 (1): 309–320.
Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors
Biochem Soc Trans (2022) 50 (1): 335–345.
Norovirus–glycan interactions — how strong are they really?
Thomas Peters; Robert Creutznacher; Thorben Maass; Alvaro Mallagaray; Patrick Ogrissek; Stefan Taube; Lars Thiede; Charlotte Uetrecht
Biochem Soc Trans (2022) 50 (1): 347–359.
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders
Biochem Soc Trans (2022) 50 (1): 361–373.
Tyrosine-O-sulfation is a widespread affinity enhancer among thrombin interactors
Biochem Soc Trans (2022) 50 (1): 387–401.
Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
Biochem Soc Trans (2022) 50 (1): 423–437.
Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesity
Biochem Soc Trans (2022) 50 (1): 447–457.
Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits
Biochem Soc Trans (2022) 50 (1): 459–22W.
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation
Biochem Soc Trans (2022) 50 (1): 473–485.
Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells
Biochem Soc Trans (2022) 50 (1): 499–511.
Bioimaging approaches for quantification of individual cell behavior during cell fate decisions
Biochem Soc Trans (2022) 50 (1): 513–527.
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
Biochem Soc Trans (2022) 50 (1): 529–539.
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
Biochem Soc Trans (2022) 50 (1): 541–554.
How lipids affect the energetics of co-translational alpha helical membrane protein folding
Biochem Soc Trans (2022) 50 (1): 555–567.
Exploring cryo-electron microscopy with molecular dynamics
John W. Vant; Daipayan Sarkar; Jonathan Nguyen; Alexander T. Baker; Josh V. Vermaas; Abhishek Singharoy
Biochem Soc Trans (2022) 50 (1): 569–581.
Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits
Biochem Soc Trans (2022) 50 (1): 583–596.
Understanding the key functions of Myosins in viral infection
Biochem Soc Trans (2022) 50 (1): 597–607.
Organismal and cellular interactions in vertebrate–alga symbioses
Biochem Soc Trans (2022) 50 (1): 609–620.
Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway
Biochem Soc Trans (2022) 50 (1): 621–632.
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?
Biochem Soc Trans (2022) 50 (1): 633–648.
