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December 2021
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Close ModalFuelled by the ‘resolution revolution’, cryo-EM has transformed our molecular understanding of transcriptional regulation in bacteria. As an example, Wood and colleagues (pp. 2695–2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. “E. coli Bacteria” by NIAID is licensed under CC BY 2.0. Cover artwork courtesy of Christopher Horne.
ISSN 0300-5127
EISSN 1470-8752
In this Issue
Review Articles
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria
Benjamin A. Ford; Geraldine J. Sullivan; Lisa Moore; Deepa Varkey; Hannah Zhu; Martin Ostrowski; Bridget C. Mabbutt; Ian T. Paulsen; Bhumika S. Shah
Biochem Soc Trans (2021) 49 (6): 2465–2481.
PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling
Biochem Soc Trans (2021) 49 (6): 2495–2507.
How a cell decides its own fate: a single-cell view of molecular mechanisms and dynamics of cell-type specification
Biochem Soc Trans (2021) 49 (6): 2509–2525.
Alpha-to-beta cell trans-differentiation for treatment of diabetes
Biochem Soc Trans (2021) 49 (6): 2539–2548.
The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
Biochem Soc Trans (2021) 49 (6): 2549–2560.
Isocitrate dehydrogenase gene variants in cancer and their clinical significance
Biochem Soc Trans (2021) 49 (6): 2561–2572.
Structural and functional approaches to studying cAMP regulation of HCN channels
Biochem Soc Trans (2021) 49 (6): 2573–2579.
Spatiotemporal regulation of store-operated calcium entry in cancer metastasis
Biochem Soc Trans (2021) 49 (6): 2581–2589.
Regulation of spatially restricted gene expression: linking RNA localization and phase separation
Biochem Soc Trans (2021) 49 (6): 2591–2600.
Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium
Biochem Soc Trans (2021) 49 (6): 2601–2610.
Applications of Cryo-EM in small molecule and biologics drug design
Biochem Soc Trans (2021) 49 (6): 2627–2638.
Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin
Biochem Soc Trans (2021) 49 (6): 2639–2653.
Regulation and functional role of the electron transport chain supercomplexes
Biochem Soc Trans (2021) 49 (6): 2655–2668.
Modularity of membrane-bound charge-translocating protein complexes
Biochem Soc Trans (2021) 49 (6): 2669–2685.
Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death
Biochem Soc Trans (2021) 49 (6): 2697–2710.
Using cryo-EM to uncover mechanisms of bacterial transcriptional regulation
Biochem Soc Trans (2021) 49 (6): 2711–2726.
The role of chromatin at transcription-replication conflicts as a genome safeguard
Biochem Soc Trans (2021) 49 (6): 2727–2736.
Directed evolution approaches for optogenetic tool development
Biochem Soc Trans (2021) 49 (6): 2737–2748.
Challenges and approaches to studying pore-forming proteins
Biochem Soc Trans (2021) 49 (6): 2749–2765.
Chromosome clustering in mitosis by the nuclear protein Ki-67
Biochem Soc Trans (2021) 49 (6): 2767–2776.
Insights into neurodegeneration from electron microscopy studies
Biochem Soc Trans (2021) 49 (6): 2777–2786.
The role of protein acetylation in regulating mitochondrial fusion and fission
Biochem Soc Trans (2021) 49 (6): 2807–2819.
Artificial protein assemblies with well-defined supramolecular protein nanostructures
Biochem Soc Trans (2021) 49 (6): 2821–2830.
Primary cilium-dependent autophagy in the response to shear stress
Biochem Soc Trans (2021) 49 (6): 2831–2839.
Non-canonical roles of autophagy proteins in endocytosis and exocytosis
Biochem Soc Trans (2021) 49 (6): 2841–2851.
Pluripotency transcription factors at the focus: the phase separation paradigm in stem cells
Biochem Soc Trans (2021) 49 (6): 2871–2878.
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines
Biochem Soc Trans (2021) 49 (6): 2879–2890.
Writing and erasing O-GlcNAc from target proteins in cells
Biochem Soc Trans (2021) 49 (6): 2891–2901.
Live-cell visualization of cytochrome c: a tool to explore apoptosis
Biochem Soc Trans (2021) 49 (6): 2903–2915.
Controlled power: how biology manages succinate-driven energy release
Biochem Soc Trans (2021) 49 (6): 2929–2939.
