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Issues
November 2021
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Cover Image
Cover Image
Long Terminal Repeat (LTR) retrotransposons replicate through “copy and paste” mechanisms mediated by reverse transcription in virus-like particles (VLPs) and integration in the nucleus (see article from Lee and Martienssen, pp. 2241–2251). VLP DNA-sequencing reveals complementary DNA (cDNA) replication intermediates from active retrotransposons. Instead of functional linear intermediates that integrate in the nucleus, the Arabidopsis retroelement SISYPHUS lacks features important for nuclear import, and instead accumulates circular cDNA from futile autointegration within the VLP. In Greek mythology, Sisyphus was condemned to the futile task of rolling a huge boulder uphill eternally. Image created and provided Seung Cho Lee, Evan Ernst, and Robert A. Martienssen.
ISSN 0300-5127
EISSN 1470-8752
In this Issue
Review Articles
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells
Biochem Soc Trans (2021) 49 (5): 1891–1903.
Integrated mass spectrometry-based multi-omics for elucidating mechanisms of bacterial virulence
Biochem Soc Trans (2021) 49 (5): 1905–1926.
Ca2+-dependent modulation of voltage-gated myocyte sodium channels
Biochem Soc Trans (2021) 49 (5): 1941–1961.
Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity
Biochem Soc Trans (2021) 49 (5): 1985–1995.
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity
Biochem Soc Trans (2021) 49 (5): 2007–2019.
Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer
Biochem Soc Trans (2021) 49 (5): 2021–2035.
To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma
Biochem Soc Trans (2021) 49 (5): 2073–2079.
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease
Biochem Soc Trans (2021) 49 (5): 2091–2100.
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
Biochem Soc Trans (2021) 49 (5): 2101–2111.
Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency
Biochem Soc Trans (2021) 49 (5): 2113–2122.
Progress and challenges in understanding the regulation and function of p53 dynamics
Biochem Soc Trans (2021) 49 (5): 2123–2131.
Controlled metabolic cascades for protein synthesis in an artificial cell
Biochem Soc Trans (2021) 49 (5): 2143–2151.
The role of long non-coding RNAs in the regulation of pancreatic beta cell identity
Biochem Soc Trans (2021) 49 (5): 2153–2161.
Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Thermodynamic and structural basis of temperature-dependent gating in TRP channels
Biochem Soc Trans (2021) 49 (5): 2211–2219.
U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs
Biochem Soc Trans (2021) 49 (5): 2229–2240.
Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
Biochem Soc Trans (2021) 49 (5): 2253–2269.
Bioengineering silk into blood vessels
Yuen Ting Lam; Richard P. Tan; Praveesuda L. Michael; Kieran Lau; Nianji Yang; Jelena Rnjak-Kovacina; Steven G. Wise
Biochem Soc Trans (2021) 49 (5): 2271–2286.
Extracellular Hsp90 and protection of neuronal cells through Nrf2
Stuart K. Calderwood; Thiago J. Borges; Takanori Eguchi; Benjamin J. Lang; Ayesha Murshid; Yuka Okusha; Thomas L. Prince
Biochem Soc Trans (2021) 49 (5): 2299–2306.
Structure determination of GPCRs: cryo-EM compared with X-ray crystallography
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Correlative nanophotonic approaches to enlighten the nanoscale dynamics of living cell membranes
Biochem Soc Trans (2021) 49 (5): 2357–2369.
Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
Biochem Soc Trans (2021) 49 (5): 2381–2395.
Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments
Biochem Soc Trans (2021) 49 (5): 2411–2429.
Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?
Biochem Soc Trans (2021) 49 (5): 2455–2463.
