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October 2016
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Close ModalAlternative splicing of intrinsically disordered segments can rewire protein interaction networks. In this issue, the Biochemical Society’s Colworth Medal winner, M. Madan Babu explores the contribution of intrinsically disordered regions to protein function, cellular complexity and human disease; see pages 1185–1200. [Credit: Guilhem Chalancon, MRC Laboratory of Molecular Biology, Cambridge, UK.]
ISSN 0300-5127
EISSN 1470-8752
In this Issue
Biochemical Society Awards
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
Biochem Soc Trans (2016) 44 (5): 1185–1200.
The unconventional kinetoplastid kinetochore: from discovery toward functional understanding
Biochem Soc Trans (2016) 44 (5): 1201–1217.
Understanding and preventing mitochondrial oxidative damage
Biochem Soc Trans (2016) 44 (5): 1219–1226.
Cilia, Cytoskeleton and Cancer
Primary cilia: a link between hormone signalling and endocrine-related cancers?
Biochem Soc Trans (2016) 44 (5): 1227–1234.
Disease mechanisms of X-linked retinitis pigmentosa due to RP2 and RPGR mutations
Biochem Soc Trans (2016) 44 (5): 1235–1244.
Using induced pluripotent stem cells to understand retinal ciliopathy disease mechanisms and develop therapies
David A. Parfitt; Amelia Lane; Conor Ramsden; Katarina Jovanovic; Peter J. Coffey; Alison J. Hardcastle; Michael E. Cheetham
Biochem Soc Trans (2016) 44 (5): 1245–1251.
The PLK4–STIL–SAS-6 module at the core of centriole duplication
Biochem Soc Trans (2016) 44 (5): 1253–1263.
Regulation of primary cilia formation by the ubiquitin–proteasome system
Biochem Soc Trans (2016) 44 (5): 1265–1271.
Shuttling and sorting lipid-modified cargo into the cilia
Biochem Soc Trans (2016) 44 (5): 1273–1280.
EML proteins in microtubule regulation and human disease
Biochem Soc Trans (2016) 44 (5): 1281–1288.
Diaphanous-related formin 1 as a target for tumor therapy
Biochem Soc Trans (2016) 44 (5): 1289–1293.
Phosphatases and Signalling in Health and Disease
Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains
Biochem Soc Trans (2016) 44 (5): 1295–1303.
Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3
Biochem Soc Trans (2016) 44 (5): 1305–1312.
Regulation of the phosphatase PP2B by protein–protein interactions
Biochem Soc Trans (2016) 44 (5): 1313–1319.
The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases
Biochem Soc Trans (2016) 44 (5): 1321–1337.
Cytoskeleton, Cell Adhesion and Migration
Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer
Biochem Soc Trans (2016) 44 (5): 1347–1354.
RNA
Attacking HIV-1 RNA versus DNA by sequence-specific approaches: RNAi versus CRISPR-Cas
Biochem Soc Trans (2016) 44 (5): 1355–1365.
Transcription by RNA polymerase III: insights into mechanism and regulation
Biochem Soc Trans (2016) 44 (5): 1367–1375.
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease
Biochem Soc Trans (2016) 44 (5): 1377–1384.
Nucleotide modifications in messenger RNA and their role in development and disease
Biochem Soc Trans (2016) 44 (5): 1385–1393.
The multiple roles of the nucleocapsid in retroviral RNA conversion into proviral DNA by reverse transcriptase
Biochem Soc Trans (2016) 44 (5): 1427–1440.
BMP Signalling in Cancer
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis
Biochem Soc Trans (2016) 44 (5): 1455–1463.
Mitochondria in Health and Disease
Polyadenylation and degradation of RNA in the mitochondria
Biochem Soc Trans (2016) 44 (5): 1475–1482.
Insights into the post-transcriptional regulation of the mitochondrial electron transport chain
Biochem Soc Trans (2016) 44 (5): 1491–1498.
Education and Outreach
Protein Interactions in Biology
Synthetic Biology
Membrane Proteins from Amino Acids to Zinc
The multiple assemblies of VDAC: from conformational heterogeneity to β-aggregation and amyloid formation
Biochem Soc Trans (2016) 44 (5): 1531–1540.
Can the Drosophila model help in paving the way for translational medicine in heart failure?
Biochem Soc Trans (2016) 44 (5): 1549–1560.
