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Volume 40, Issue 1

February 2012

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Cover Image

Cover Image
Front Matter
Table of Contents

ISSN 0300-5127

EISSN 1470-8752

In this Issue

Biochemical Society Focused Meetings
- Signalling 2011: a Biochemical Society Centenary Celebration
Corrections

Biochemical Society Focused Meetings

Signalling 2011: a Biochemical Society Centenary Celebration

Novel control of cAMP-regulated transcription in vascular endothelial cells

Gillian R. Milne; Timothy M. Palmer; Stephen J. Yarwood

Biochem Soc Trans (2012) 40 (1): 1–5.

Abstract

View Articletitled, Novel control of cAMP-regulated transcription in vascular endothelial cells

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Epac2: a sulfonylurea receptor?

Holger Rehmann

Biochem Soc Trans (2012) 40 (1): 6–10.

Abstract

View Articletitled, Epac2: a sulfonylurea receptor?

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cGMP–cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function

Alessandra Stangherlin; Manuela Zaccolo

Biochem Soc Trans (2012) 40 (1): 11–14.

Abstract

View Articletitled, cGMP–cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function

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Negative co-operativity in the EGF receptor

Linda J. Pike

Biochem Soc Trans (2012) 40 (1): 15–19.

Abstract

View Articletitled, Negative co-operativity in the EGF receptor

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Neuropilin signalling in angiogenesis

Sina Koch

Biochem Soc Trans (2012) 40 (1): 20–25.

Abstract

View Articletitled, Neuropilin signalling in angiogenesis

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Regulation of signalling by microRNAs

Roi Avraham; Yosef Yarden

Biochem Soc Trans (2012) 40 (1): 26–30.

Abstract

View Articletitled, Regulation of signalling by microRNAs

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Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis

Mari Gotoh; Yuko Fujiwara; Junming Yue; Jianxiong Liu; SueChin Lee; James Fells; Ayako Uchiyama; Kimiko Murakami-Murofushi; Stephen Kennel; Jonathan Wall; Renukadevi Patil; Renuka Gupte; Louisa Balazs; Duane D. Miller; Gabor J. Tigyi

Biochem Soc Trans (2012) 40 (1): 31–36.

Abstract

View Articletitled, Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis

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How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal

Nicholas T. Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo

Biochem Soc Trans (2012) 40 (1): 37–43.

Abstract

View Articletitled, How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal

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The essential role of cAMP/Ca²⁺ signalling in mammalian circadian timekeeping

John S. O'Neill; Akhilesh B. Reddy

Biochem Soc Trans (2012) 40 (1): 44–50.

Abstract

View Articletitled, The essential role of cAMP/Ca2+ signalling in mammalian circadian timekeeping

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Role of Epac in brain and heart

Anne-Coline Laurent; Magali Breckler; Magali Berthouze; Frank Lezoualc'h

Biochem Soc Trans (2012) 40 (1): 51–57.

Abstract

View Articletitled, Role of Epac in brain and heart

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Immediate-early gene activation by the MAPK pathways: what do and don't we know?

Amanda O'Donnell; Zaneta Odrowaz; Andrew D. Sharrocks

Biochem Soc Trans (2012) 40 (1): 58–66.

Abstract

View Articletitled, Immediate-early gene activation by the MAPK pathways: what do and don't we know?

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Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

Catherine Andreadi; Catherine Noble; Bipin Patel; Hong Jin; Maria M. Aguilar Hernandez; Kathryn Balmanno; Simon J. Cook; Catrin Pritchard

Biochem Soc Trans (2012) 40 (1): 67–72.

Abstract

View Articletitled, Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

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Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling

Annette S. Little; Kathryn Balmanno; Matthew J. Sale; Paul D. Smith; Simon J. Cook

Biochem Soc Trans (2012) 40 (1): 73–78.

Abstract

View Articletitled, Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling

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Roles of p38 MAPKs in invasion and metastasis

Ivan del Barco Barrantes; Angel R. Nebreda

Biochem Soc Trans (2012) 40 (1): 79–84.

Abstract

View Articletitled, Roles of p38 MAPKs in invasion and metastasis

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Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

Clare Davies; Cathy Tournier

Biochem Soc Trans (2012) 40 (1): 85–89.

Abstract

View Articletitled, Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

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Phosphorylation of basic helix–loop–helix transcription factor Twist in development and disease

Gongda Xue; Brian A. Hemmings

Biochem Soc Trans (2012) 40 (1): 90–93.

Abstract

View Articletitled, Phosphorylation of basic helix–loop–helix transcription factor Twist in development and disease

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Sphingosine 1-phosphate signalling in cancer

Nigel J. Pyne; Francesca Tonelli; Keng Gat Lim; Jaclyn S. Long; Joanne Edwards; Susan Pyne

Biochem Soc Trans (2012) 40 (1): 94–100.

Abstract

View Articletitled, Sphingosine 1-phosphate signalling in cancer

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The glycerophosphoinositols and their cellular functions

Daniela Corda; Pasquale Zizza; Alessia Varone; Karol S. Bruzik; Stefania Mariggiò

Biochem Soc Trans (2012) 40 (1): 101–107.

Abstract

View Articletitled, The glycerophosphoinositols and their cellular functions

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Cellular geography of IP₃ receptors, STIM and Orai: a lesson from secretory epithelial cells

Hayley Dingsdale; Svetlana Voronina; Lee Haynes; Alexei Tepikin; Gyorgy Lur

Biochem Soc Trans (2012) 40 (1): 108–111.

Abstract

View Articletitled, Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells

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Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes

Wei-Wei Shen; Nicolas Demaurex

Biochem Soc Trans (2012) 40 (1): 112–118.

Abstract

View Articletitled, Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes

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Regulation of store-operated calcium entry during cell division

Jeremy T. Smyth; James W. Putney

Biochem Soc Trans (2012) 40 (1): 119–123.

Abstract

View Articletitled, Regulation of store-operated calcium entry during cell division

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Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions

Alexander Hergovich

Biochem Soc Trans (2012) 40 (1): 124–128.

Abstract

View Articletitled, Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions

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Cell migration and invasion in human disease: the Tks adaptor proteins

Sara A. Courtneidge

Biochem Soc Trans (2012) 40 (1): 129–132.

Abstract

View Articletitled, Cell migration and invasion in human disease: the Tks adaptor proteins

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Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments

David C. Clarke; Douglas A. Lauffenburger

Biochem Soc Trans (2012) 40 (1): 133–138.

Abstract

View Articletitled, Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments

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Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

Edita Aksamitiene; Anatoly Kiyatkin; Boris N. Kholodenko

Biochem Soc Trans (2012) 40 (1): 139–146.

Abstract

View Articletitled, Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

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From parathyroid hormone to cytosolic Ca²⁺ signals

Colin W. Taylor; Stephen C. Tovey

Biochem Soc Trans (2012) 40 (1): 147–152.

Abstract

View Articletitled, From parathyroid hormone to cytosolic Ca2+ signals

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Triggering of Ca²⁺ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Sandip Patel; Eugen Brailoiu

Biochem Soc Trans (2012) 40 (1): 153–157.

Abstract

View Articletitled, Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

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Mitochondrial organization and Ca²⁺ uptake

Marnie L. Olson; Susan Chalmers; John G. McCarron

Biochem Soc Trans (2012) 40 (1): 158–167.

Abstract

View Articletitled, Mitochondrial organization and Ca2+ uptake

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Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis

Valentina Iadevaia; Yilin Huo; Ze Zhang; Leonard J. Foster; Christopher G. Proud

Biochem Soc Trans (2012) 40 (1): 168–172.

Abstract

View Articletitled, Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis

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DNA double-strand break repair within heterochromatic regions

Johanne M. Murray; Tom Stiff; Penny A. Jeggo

Biochem Soc Trans (2012) 40 (1): 173–178.

Abstract

View Articletitled, DNA double-strand break repair within heterochromatic regions

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cAMP measurements with FRET-based sensors in excitable cells

Katy L. Everett; Dermot M.F. Cooper

Biochem Soc Trans (2012) 40 (1): 179–183.

Abstract

View Articletitled, cAMP measurements with FRET-based sensors in excitable cells

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Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry

Marisa L. Martin-Fernandez

Biochem Soc Trans (2012) 40 (1): 184–188.

Abstract

View Articletitled, Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry

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Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy

Selene K. Roberts; Christopher J. Tynan; Martyn Winn; Marisa L. Martin-Fernandez

Biochem Soc Trans (2012) 40 (1): 189–194.

Abstract

View Articletitled, Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy

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The regulatory role of the juxtamembrane region in the activity of the epidermal growth factor receptor

Aislyn D.W. Boran

Biochem Soc Trans (2012) 40 (1): 195–199.

Abstract

View Articletitled, The regulatory role of the juxtamembrane region in the activity of the epidermal growth factor receptor

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Non-genomic progesterone signalling and its non-canonical receptor

Patricia Moussatche; Thomas J. Lyons

Biochem Soc Trans (2012) 40 (1): 200–204.

Abstract

View Articletitled, Non-genomic progesterone signalling and its non-canonical receptor

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Growth and metabolic control of lipid signalling at the Golgi

Hailan Piao; Peter Mayinger

Biochem Soc Trans (2012) 40 (1): 205–209.

Abstract

View Articletitled, Growth and metabolic control of lipid signalling at the Golgi

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PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

Helen V. Edwards; John D. Scott; George S. Baillie

Biochem Soc Trans (2012) 40 (1): 210–214.

Abstract

View Articletitled, PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

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Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3

Jamie J.L. Williams; Timothy M. Palmer

Biochem Soc Trans (2012) 40 (1): 215–218.

Abstract

View Articletitled, Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3

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cAMP-dependent allostery and dynamics in Epac: an NMR view

Rajeevan Selvaratnam; Madoka Akimoto; Bryan VanSchouwen; Giuseppe Melacini

Biochem Soc Trans (2012) 40 (1): 219–223.

Abstract

View Articletitled, cAMP-dependent allostery and dynamics in Epac: an NMR view

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ERK phosphorylation and nuclear accumulation: insights from single-cell imaging

Christopher J. Caunt; Craig A. McArdle

Biochem Soc Trans (2012) 40 (1): 224–229.

Abstract

View Articletitled, ERK phosphorylation and nuclear accumulation: insights from single-cell imaging

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The roles of ATF2 (activating transcription factor 2) in tumorigenesis

Malgorzata Gozdecka; Wolfgang Breitwieser

Biochem Soc Trans (2012) 40 (1): 230–234.

Abstract

View Articletitled, The roles of ATF2 (activating transcription factor 2) in tumorigenesis

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MKP-2: out of the DUSP-bin and back into the limelight

Ahmed Lawan; Emma Torrance; Sameer Al-Harthi; Muhannad Shweash; Sulaiman Alnasser; Thikryat Neamatallah; Juliane Schroeder; Robin Plevin

Biochem Soc Trans (2012) 40 (1): 235–239.

Abstract

View Articletitled, MKP-2: out of the DUSP-bin and back into the limelight

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Targeting phosphoinositide 3-kinase δ for allergic asthma

Wendy C. Rowan; Janet L. Smith; Karen Affleck; Augustin Amour

Biochem Soc Trans (2012) 40 (1): 240–245.

Abstract

View Articletitled, Targeting phosphoinositide 3-kinase δ for allergic asthma

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Organization of cAMP signalling microdomains for optimal regulation by Ca²⁺ entry

Debbie Willoughby

Biochem Soc Trans (2012) 40 (1): 246–250.

Abstract

View Articletitled, Organization of cAMP signalling microdomains for optimal regulation by Ca2+ entry

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ERK5 and its role in tumour development

Pamela A. Lochhead; Rebecca Gilley; Simon J. Cook

Biochem Soc Trans (2012) 40 (1): 251–256.

Abstract

View Articletitled, ERK5 and its role in tumour development

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The emerging role of PtdIns5P: another signalling phosphoinositide takes its place

Deborah L. Grainger; Christodoulos Tavelis; Alexander J. Ryan; Katherine A. Hinchliffe

Biochem Soc Trans (2012) 40 (1): 257–261.

Abstract

View Articletitled, The emerging role of PtdIns5P: another signalling phosphoinositide takes its place

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The regulation of myosin phosphatase in pregnant human myometrium

Claire A. Hudson; Andrés López Bernal

Biochem Soc Trans (2012) 40 (1): 262–267.

Abstract

View Articletitled, The regulation of myosin phosphatase in pregnant human myometrium

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The small Rho GTPase Rif and actin cytoskeletal remodelling

Lifei Fan; Harry Mellor

Biochem Soc Trans (2012) 40 (1): 268–272.

Abstract

View Articletitled, The small Rho GTPase Rif and actin cytoskeletal remodelling

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Decoding neurohormone pulse frequency by convergent signalling modules

Krasimira Tsaneva-Atanasova; Christopher J. Caunt; Stephen P. Armstrong; Rebecca M. Perrett; Craig A. McArdle

Biochem Soc Trans (2012) 40 (1): 273–278.

Abstract

View Articletitled, Decoding neurohormone pulse frequency by convergent signalling modules

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IP₃R, store-operated Ca²⁺ entry and neuronal Ca²⁺ homoeostasis in Drosophila

Sumita Chakraborty; Gaiti Hasan

Biochem Soc Trans (2012) 40 (1): 279–281.

Abstract

View Articletitled, IP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila

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Putative roles for phospholipase Cη enzymes in neuronal Ca²⁺ signal modulation

Petra Popovics; Alan J. Stewart

Biochem Soc Trans (2012) 40 (1): 282–286.

Abstract

View Articletitled, Putative roles for phospholipase Cη enzymes in neuronal Ca2+ signal modulation

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Protein kinase D in the hypertrophy pathway

Yuan Yan Sin; George S. Baillie

Biochem Soc Trans (2012) 40 (1): 287–289.

Abstract

View Articletitled, Protein kinase D in the hypertrophy pathway

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Histone H4 histidine phosphorylation: kinases, phosphatases, liver regeneration and cancer

Paul G. Besant; Paul V. Attwood

Biochem Soc Trans (2012) 40 (1): 290–293.

Abstract

View Articletitled, Histone H4 histidine phosphorylation: kinases, phosphatases, liver regeneration and cancer

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Corrections

The metagenomic basis of anammox metabolism in Candidatus ‘Brocadia fulgida’

Fabio Gori; Susannah Green Tringe; Boran Kartal; Elena Marchiori; Mike S.M. Jetten

Biochem Soc Trans (2012) 40 (1): 295.

Extract

View Articletitled, The metagenomic basis of anammox metabolism in Candidatus ‘Brocadia fulgida’

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