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Issues
November 2007
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ISSN 0300-5127
EISSN 1470-8752
Biochemical Society Awards
Colworth Medal Lecture
Life Sciences 2007
Cardiovascular Bioscience
Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH)
Biochem Soc Trans (2007) 35 (5): 870–875.
Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases
Biochem Soc Trans (2007) 35 (5): 890–894.
Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling
Biochem Soc Trans (2007) 35 (5): 905–907.
The potential roles of sphingolipids in vascular smooth-muscle function
Biochem Soc Trans (2007) 35 (5): 908–909.
Signalling
Plasma-membrane Ca2+ pumps: structural diversity as the basis for functional versatility
Biochem Soc Trans (2007) 35 (5): 919–922.
Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers
Biochem Soc Trans (2007) 35 (5): 923–926.
The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart
Biochem Soc Trans (2007) 35 (5): 927–930.
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
Biochem Soc Trans (2007) 35 (5): 931–937.
Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction
Biochem Soc Trans (2007) 35 (5): 946–951.
Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid
Biochem Soc Trans (2007) 35 (5): 957–961.
Insights into the structure and protein–protein interactions of the pro-apoptotic protein ASPP2
Biochem Soc Trans (2007) 35 (5): 966–969.
Protein–protein interactions in the assembly and subcellular trafficking of the BACE (β-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease
Biochem Soc Trans (2007) 35 (5): 974–979.
Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils
Biochem Soc Trans (2007) 35 (5): 985–990.
Magic-angle-spinning NMR spectroscopy applied to small molecules and peptides in lipid bilayers
Biochem Soc Trans (2007) 35 (5): 991–995.
Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer
Biochem Soc Trans (2007) 35 (5): 996–1000.
Protein kinases, from B to C
A.J. Cameron; M. De Rycker; V. Calleja; D. Alcor; S. Kjaer; B. Kostelecky; A. Saurin; A. Faisal; M. Laguerre; B.A. Hemmings; N. McDonald; B. Larijani; P.J. Parker
Biochem Soc Trans (2007) 35 (5): 1013–1017.
Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic
Biochem Soc Trans (2007) 35 (5): 1021–1026.
Functional domains of the mouse β3-adrenoceptor associated with differential G-protein coupling
Biochem Soc Trans (2007) 35 (5): 1035–1037.
Study of the functional role of Bcl-2 family proteins in regulating Ca2+ signals in apoptotic cells
Biochem Soc Trans (2007) 35 (5): 1038–1039.
The roles of PKCδ and ϵ isoenzymes in the regulation of myocardial ischaemia/reperfusion injury
Biochem Soc Trans (2007) 35 (5): 1040–1042.
The C2 domains of classical/conventional PKCs are specific PtdIns(4,5)P2-sensing domains
Biochem Soc Trans (2007) 35 (5): 1046–1048.
Aldosterone-stimulated PKC signalling cascades: from receptor to effector
Biochem Soc Trans (2007) 35 (5): 1049–1051.
Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Ion Channel
Trafficking of ATP-sensitive potassium channels in health and disease
Biochem Soc Trans (2007) 35 (5): 1055–1059.
hERG channel trafficking: novel targets in drug-induced long QT syndrome
Biochem Soc Trans (2007) 35 (5): 1060–1063.
Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Localization and trafficking of cardiac voltage-gated potassium channels
Biochem Soc Trans (2007) 35 (5): 1069–1073.
Voltage clamp fluorimetry studies of mammalian voltage-gated K+ channel gating
Biochem Soc Trans (2007) 35 (5): 1080–1082.
Inflammation
Phagosomal acidification: measurement, manipulation and functional consequences
Biochem Soc Trans (2007) 35 (5): 1083–1087.
The role of calcium and other ions in sorting and delivery in the late endocytic pathway
Biochem Soc Trans (2007) 35 (5): 1088–1091.
The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs
Biochem Soc Trans (2007) 35 (5): 1100–1103.
Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase
Biochem Soc Trans (2007) 35 (5): 1109–1113.
An overview of the biological significance of endogenous gases: new roles for old molecules
Biochem Soc Trans (2007) 35 (5): 1138–1141.
Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities
Biochem Soc Trans (2007) 35 (5): 1142–1146.
Redox regulation of lung inflammation: role of NADPH oxidase and NF-κB signalling
H. Yao; S.-R. Yang; A. Kode; S. Rajendrasozhan; S. Caito; D. Adenuga; R. Henry; I. Edirisinghe; I. Rahman
Biochem Soc Trans (2007) 35 (5): 1151–1155.
Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
Biochem Soc Trans (2007) 35 (5): 1156–1160.
Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment
Biochem Soc Trans (2007) 35 (5): 1161–1162.
Systemic inflammation and stroke: aetiology, pathology and targets for therapy
Biochem Soc Trans (2007) 35 (5): 1163–1165.
Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system
Biochem Soc Trans (2007) 35 (5): 1166–1167.
P2X7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Metabolism
Intestinal glucose sensing and regulation of intestinal glucose absorption
Biochem Soc Trans (2007) 35 (5): 1191–1194.
Physiological significance of L-amino acid sensing by extracellular Ca2+-sensing receptors
Biochem Soc Trans (2007) 35 (5): 1195–1198.
Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells
Biochem Soc Trans (2007) 35 (5): 1208–1210.
Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation
Biochem Soc Trans (2007) 35 (5): 1211–1214.
Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?
Biochem Soc Trans (2007) 35 (5): 1215–1217.
Central Nervous System
Synaptic memory mechanisms: Alzheimer's disease amyloid β-peptide-induced dysfunction
Biochem Soc Trans (2007) 35 (5): 1219–1223.
Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide
Biochem Soc Trans (2007) 35 (5): 1224–1227.
Do mitochondrial DNA mutations have a role in neurodegenerative disease?
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons
Biochem Soc Trans (2007) 35 (5): 1236–1242.
Nitric oxide and respiratory rhythm in mammals: a new modulator of phase transition?
Biochem Soc Trans (2007) 35 (5): 1258–1263.
Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing
Biochem Soc Trans (2007) 35 (5): 1264–1268.
Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species
Biochem Soc Trans (2007) 35 (5): 1269–1272.
Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors
Biochem Soc Trans (2007) 35 (5): 1273–1277.
Exercise
The role of nutrition in stimulating muscle protein accretion at the molecular level
Biochem Soc Trans (2007) 35 (5): 1298–1301.
Exercise- and nutrient-controlled mechanisms involved in maintenance of the musculoskeletal mass
Biochem Soc Trans (2007) 35 (5): 1302–1305.
Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training
Biochem Soc Trans (2007) 35 (5): 1306–1309.
Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways
Biochem Soc Trans (2007) 35 (5): 1310–1311.
Mechanotransduction in striated muscle via focal adhesion kinase
Biochem Soc Trans (2007) 35 (5): 1312–1313.
Bacteria
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets
Biochem Soc Trans (2007) 35 (5): 1325–1328.
Cancer
Role played by BRCA1 in transcriptional regulation in response to therapy
Biochem Soc Trans (2007) 35 (5): 1342–1346.
DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy
Biochem Soc Trans (2007) 35 (5): 1352–1354.
Determining the efficacy of dietary phytochemicals in cancer prevention
Biochem Soc Trans (2007) 35 (5): 1358–1363.
Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?
Biochem Soc Trans (2007) 35 (5): 1369–1371.
O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines
G. Patsos; C. Robbe-Masselot; A. Klein; V. Hebbe-Viton; R. San Martin; D. Masselot; M. Graessmann; C. Paraskeva; T. Gallagher; A. Corfield
Biochem Soc Trans (2007) 35 (5): 1372–1374.
Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10−/−) mice
Biochem Soc Trans (2007) 35 (5): 1375–1376.
Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer
Biochem Soc Trans (2007) 35 (5): 1377–1378.
