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June 2002
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
676th Meeting
Tetrapyrroles: their Birth, Life and Death
Structure and function of glutamyl-tRNA reductase involved in 5-aminolevulinic acid formation
Biochem Soc Trans (2002) 30 (3): A47.
Structural diversity in metal ion chelation, and the structure of uro'gen III synthase
Biochem Soc Trans (2002) 30 (3): A48.
Two enzymes for oxygen-dependent and independent decarboxylation of coproporphyrinogen III during bacterial tetrapyrrole biosynthesis
Biochem Soc Trans (2002) 30 (3): A48.
An investigation into the mechanism of SirB from Bacillus megaterium - a Sirohydrochlorin ferrochelatase
Biochem Soc Trans (2002) 30 (3): A49.
Structure of an unusual haemoprotein involved in thiosulfate oxidation
Biochem Soc Trans (2002) 30 (3): A50.
The coupling of ATP hydrolysis to metal ion insertion into porphyrins by magnesium chelatase
Biochem Soc Trans (2002) 30 (3): A50.
Bacterial cytochrome c nitrite reductase: three-dimensional structure and spectroscopy of the multiheme enzyme
Biochem Soc Trans (2002) 30 (3): A51.
Spectroscopic characterisation of Cytochrome cbb3 oxidase from Pseudomonas stutzeri
Biochem Soc Trans (2002) 30 (3): A52.
The role of membrane bound tetraheme CymA in the anaerobic respiration of Shewanella oneidensis MR-1
Biochem Soc Trans (2002) 30 (3): A53.
Amyloidogenic Proteins Involved in Neurodegeneration and Therapeutic Implications
Transgenic models of Alzheimer's disease: behavioural studies and the prospects of therapeutic immunization
Biochem Soc Trans (2002) 30 (3): A55.
Inhibition of toxicity and protofibril formation in the β-amyloid peptide β(25–35) using N-Methylated derivatives
Biochem Soc Trans (2002) 30 (3): A55.
Amyloid fibril formation by human stefin B; influence of solvent composition, trifluoroethanol and temperature
Biochem Soc Trans (2002) 30 (3): A55.
Altering prion protein misfolding for therapy and diagnosis of transmissible spongiform encephalopathies
Biochem Soc Trans (2002) 30 (3): A57.
Quantitative detection and identification of amyloid beta peptides directly from crude biological samples using the ProteinChip® Biology System
Biochem Soc Trans (2002) 30 (3): A57.
Lessons from the Type II Family of G-protein-Coupled Receptors; Ligands, Receptor Structure and Function
Identification of the Secretin, VIP and glucagon binding sites: from chimeric receptors to point mutations
Biochem Soc Trans (2002) 30 (3): A58.
A small sequence in the third intracellular loop of the VPAC1 receptor is responsible for its efficient coupling to the calcium effector
Biochem Soc Trans (2002) 30 (3): A59.
The functional relevance of G protein receptor associated proteins exemplified by the receptor-activity-modifying proteins (RAMP)
Biochem Soc Trans (2002) 30 (3): A60.
Receptor component protein (rep): a member of a multi-protein complex required for G protein-coupled signal transduction
Biochem Soc Trans (2002) 30 (3): A60.
Interactions of G-protein coupled receptors with synaptic scaffolding proteins
Biochem Soc Trans (2002) 30 (3): A60.
In-vitro folding and functional characterization of the extracellular domain of G protein-coupled receptors
Biochem Soc Trans (2002) 30 (3): A60.
The development and potential of non-peptide antagonists for calcitonin-gene related peptide receptors
Biochem Soc Trans (2002) 30 (3): A61.
RAMPs interact with and modulate the signalling of VPAC1 receptors
Biochem Soc Trans (2002) 30 (3): A61.
14-3-3 Proteins in Cell Regulation
14-3-3 structure, function and role in neurodegenerative diseases, trafficking and nuclear signalling
Biochem Soc Trans (2002) 30 (3): A61.
Structure and function of a cAMP operated 14-3-3 binding switch: essential role in biological timing
Biochem Soc Trans (2002) 30 (3): A62.
Signalling pathways that target diverse plant and human 14-3-3-binding partners
Biochem Soc Trans (2002) 30 (3): A63.
Use of cerebrospinal fluid 14-3-3 analysis in the diagnosis of sporadic and variant Creutzfeldt-Jakob disease
Biochem Soc Trans (2002) 30 (3): A63.
Analysis of 14-3-3 isoforms in the lateral geniculate nucleus in murine brain
Biochem Soc Trans (2002) 30 (3): A63.
In vivo association of 14-3-3 isoforms with mammalian origins of DNA replication
Biochem Soc Trans (2002) 30 (3): A63.
IGF-1 induces phosphorylation of two novel residues of FKHR
Graham Rena; Yvonne L. Woods; Alan R. Prescott; Mark Peggie; Terry G. Unterman; Michayla R. Williams; Philip Cohen
Biochem Soc Trans (2002) 30 (3): A64.
Phosphorylation-independent interaction between 14-3-3 protein and the plant plasma membrane H+-ATPase
Biochem Soc Trans (2002) 30 (3): A65.
Mediation and Modulation of Antibody Function
The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors
Biochem Soc Trans (2002) 30 (3): A66.
Formatting antibody fragments to mediate specific therapeutic functions
Biochem Soc Trans (2002) 30 (3): A68.
Amino acid sequence requirements in the human IgAl hinge for cleavage by streptococcal IgAl proteases
Biochem Soc Trans (2002) 30 (3): A68.
Neurodegeneration
Characterisation of thermodynamic diversity between TSE agent strains
Biochem Soc Trans (2002) 30 (3): A69.
An investigation into the mechanism of toxicity of amyloid-forming proteins and peptides
Biochem Soc Trans (2002) 30 (3): A69.
Heparan sulphate binds the aspartic protease β-Secretase and regulates cleavage of APP
Biochem Soc Trans (2002) 30 (3): A69.
Does pentosan polysulphate have prophylactic potential for transmissible spongiform encephalopathies?
C. F. Farquhar; I. McConnell; J. Graham; S. Cumming; G. R. Barclay; A. Boyle; M. L. Turner; M. E. Bruce
Biochem Soc Trans (2002) 30 (3): A70.
Controlled release of cytochrome c from functional brain mitochondria; implications for apoptotic mechanisms in neurdegenerative disease
Biochem Soc Trans (2002) 30 (3): A70.
Chronic nicotine treatment reduces beta-amyloidosis
J. Court; E. Hellstrom-Lindhal; M. Lee; M. Johnson; M. Mousavi; R. Hall; E. Perry; I. Bednar; A. Nordberg
Biochem Soc Trans (2002) 30 (3): A70.
Changes in Nestin and AMPA receptors are associated with preconditioning of the mouse cortex by repetitive spreading depression
Biochem Soc Trans (2002) 30 (3): A70.
An investigation in changes in gene regulation and subsequent signal transduction activation after ischemic stroke
Biochem Soc Trans (2002) 30 (3): A71.
Genotype/phenotype correlation in patients with Erythropoietic Protoporphyria
Biochem Soc Trans (2002) 30 (3): A72.
Preliminary studies about the effect of acute and chronic ALA intoxication in brain mice
Biochem Soc Trans (2002) 30 (3): A73.
Spectroscopic characterisation of Cytochrome cbb3 oxidase from Pseudomonas stutzeri
Biochem Soc Trans (2002) 30 (3): A73.
An investigation into the mechanism of SirB from Bacillus megaterium - a sirohydrochlorin ferrochelatase
Biochem Soc Trans (2002) 30 (3): A73.
Cloning, expression and characterisation of ALAD from the deep-sea fish Coryphaenoides armatus
Biochem Soc Trans (2002) 30 (3): A73.
Inhibition of cytochrome c oxidase by nitrite and nitric oxide:reversible and irreversible
Biochem Soc Trans (2002) 30 (3): A74.
Spectroscopic characterisation of the substrate binding properties of NADPH:protochlorophyllide oxidoreductase (POR)
Biochem Soc Trans (2002) 30 (3): A74.
Two enzymes for oxygen-dependent and independent decarboxylation of coproporphyrinogen III during bacterial tetrapyrrole biosynthesis
Biochem Soc Trans (2002) 30 (3): A75.
Mechanistic insights into flavocytochrome c3, the soluble fumarate reductase from Shewanella frigidimarina
Biochem Soc Trans (2002) 30 (3): A75.
The coupling of ATP hydrolysis to metal ion insertion into porphyrins by magnesium chelatase
Biochem Soc Trans (2002) 30 (3): A75.
The role of membrane bound tetraheme CymA in the anaerobic respiration of Shewanella oneidensis MR-1
Biochem Soc Trans (2002) 30 (3): A75.
Spectral properties of bacterial nitric oxide reductase
Sarah J. Field; Louise Prior; M. Dolores Roldán; Myles R. Cheesman; Andrew J. Thomson; Stephen Spiro; Julea Butt; Nicholas J. Watmough; David J. Richardson
Biochem Soc Trans (2002) 30 (3): A76.
Studies on human recombinant 5-aminolaevulinic acid dehydratase and human recombinant porphobilinogen deaminase
Biochem Soc Trans (2002) 30 (3): A77.
The expression, purification and steady state analysis of magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803
Biochem Soc Trans (2002) 30 (3): A77.
20S Proteasomal degradation of α-synuclein does not generate the non-β-amyloid plaque component (NAC)
Biochem Soc Trans (2002) 30 (3): A77.
Inhibition of Toxicity and protofibril formation in the β-amyloid peptide β(25–35) using N-Methylated derivatives
Biochem Soc Trans (2002) 30 (3): A78.
Chronic nicotine treatment reduces beta-amyloidosis
J. Court; E. Hellstrom-Lindhal; M. Lee; M. Johnson; M. Mousavi; R. Hall; E. Perry; I. Bednar; A. Nordberg
Biochem Soc Trans (2002) 30 (3): A78.
Heparan sulphate binds the aspartic protease β-secretase and regulates cleavage of APP
Biochem Soc Trans (2002) 30 (3): A78.
Altered processing of the Alzheimer's amyloid precursor protein in human neuroblastoma cells expressing the prion protein
Biochem Soc Trans (2002) 30 (3): A79.
An N-methylated analogue inhibits α-synuclein(68–78) aggregation
Biochem Soc Trans (2002) 30 (3): A79.
Characterisation of thermodynamic diversity between TSE agent strains
Biochem Soc Trans (2002) 30 (3): A79.
Amyloid sequences and human prion sequences are able to functionally replace repeat regions of the prion-forming domain of yeast Sup35p
Biochem Soc Trans (2002) 30 (3): A80.
Amyloid fibril formation by human stefin B; influence of solvent composition, trifluoroethanol and temperature
Biochem Soc Trans (2002) 30 (3): A80.
A correlation study of human serum Aβ1–42 and serum cholesterol measurements
Biochem Soc Trans (2002) 30 (3): A81.
Cyclodextrin dimers and trimers inhibit the aggregation of β-amyloid
Biochem Soc Trans (2002) 30 (3): A81.
A beta-site amyloid precursor protein cleaving enzyme (BACE) assay
Biochem Soc Trans (2002) 30 (3): A81.
Does pentosan polysulphate have prophylactic potential for transmissible spongiform encephalopathies?
C. F. Farquhar; I. McConnell; J. Graham; S. Cumming; R. Prescott; G. R. Barclay; A. Boyle; M. L. Turner; M. E. Bruce
Biochem Soc Trans (2002) 30 (3): A81.
New analytical methods for the study of protein aggregation in real time
Biochem Soc Trans (2002) 30 (3): A82.
Changes in Nestin and AMPA receptors are associated with preconditioning of the mouse cortex by repetitive spreading depression
Biochem Soc Trans (2002) 30 (3): A83.
Molecular characterization of protein interactions essential for neurotransmitter exocytosis: munc18 and mint
Biochem Soc Trans (2002) 30 (3): A83.
Haem oxygenase/nitric oxide synthase interaction: a role in neurodegeneration?
Biochem Soc Trans (2002) 30 (3): A84.
An investigation in changes in gene regulation and subsequent signal transduction activation after ischemic stroke
Biochem Soc Trans (2002) 30 (3): A84.
Controlled release of cytochrome c from functional brain mitochondria; implications for apoptotic mechanisms in neur-degenerative disease
Biochem Soc Trans (2002) 30 (3): A84.
An investigation into the mechanism of toxicity of amyloid-forming proteins and peptides
Biochem Soc Trans (2002) 30 (3): A85.
Lessons from the Type II Family of G-Protein-Coupled Receptors: Ligands, Receptor Structure and Function
Adenylyl cyclase 9: biochemical and pharmacological characterisation of recombinantly expressed ‘active core’
Biochem Soc Trans (2002) 30 (3): A86.
The effect on CGRP-binding of mutations to hydrophilic residues within the second transmembrane region of human calcitonin receptor-like receptor (CRLR)
Biochem Soc Trans (2002) 30 (3): A86.
Specific interaction between ARF6 and the Hop-1 intracellular loop 3 domain of the human PAC 1 receptor
Biochem Soc Trans (2002) 30 (3): A87.
Direct interaction between the threonine 11 of Vasoactive Intestinal Polypeptide (VIP) and tyrosine 184 of the VPAC2 receptor
Biochem Soc Trans (2002) 30 (3): A88.
A small sequence in the third intracellular loop of the VPAC1 receptor is responsible for its efficient coupling to the calcium effector
Biochem Soc Trans (2002) 30 (3): A88.
Interaction of calmodulin with the intracellular C-tails of metabotropic glutamate receptors assayed with the yeast two-hybrid system
Biochem Soc Trans (2002) 30 (3): A88.
In vivo association of 14-3-3 isoforms with mammalian origins of DNA replication
Biochem Soc Trans (2002) 30 (3): A89.
A docking site on the carboxy-terminus of ERK-2 is essential for different functionality between ERK-1 and ERK-2
Biochem Soc Trans (2002) 30 (3): A89.
Use of cerebrospinal fluid 14-3-3 analysis in the diagnosis of sporadic and variant Creutzfeldt-Jakob disease
Biochem Soc Trans (2002) 30 (3): A90.
Isolation of a member of the 14-3-3 gene family from a marine alga, Fucus vesiculosus
Biochem Soc Trans (2002) 30 (3): A90.
Analysis of 14-3-3 isoforms in the lateral geniculate nucleus in murine brain
Biochem Soc Trans (2002) 30 (3): A91.
Early changes in protein kinase c and tubulinα expression in rat liver by phenobarbital
Biochem Soc Trans (2002) 30 (3): A91.
IGF-1 induces phosphorylation of two novel residues of FKHR
Graham Rena; Yvonne L. Woods; Alan R. Prescott; Mark Peggie; Terry G. Unterman; Michayla R. Williams; Philip Cohen
Biochem Soc Trans (2002) 30 (3): A91.
Anti-malaria immune effector mechanisms recruited by human IgG1 and IgA1 monoclonal antibodies
Biochem Soc Trans (2002) 30 (3): A92.
Amino acid sequence requirements in the human IgA1 hinge for cleavage by streptococcal IgA1 proteases
Biochem Soc Trans (2002) 30 (3): A92.
Chimeric human antibodies directed against a major surface antigen of Pseudomonas aeruginosa
Biochem Soc Trans (2002) 30 (3): A92.
MISCELLANEOUS
Kaempferol metabolism by rat hepatocytes cultured on different collagen substrates
Biochem Soc Trans (2002) 30 (3): A94.
The role of adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) in osteoblast metabolism
Biochem Soc Trans (2002) 30 (3): A94.
Hepatic heme-oxygenase and oxidative stress during short-term treatment with DAB
Biochem Soc Trans (2002) 30 (3): A94.
Scrapie spreads from the gastrointestinal tract to the CNS along autonomic and sensory relays of the peripheral nervous system
Biochem Soc Trans (2002) 30 (3): A95.
γ-secretase enzyme specificity toward cleavage of amyloid precursor protein and Notch
Biochem Soc Trans (2002) 30 (3): A95.
Investigation into the role of the second and third extracellular loop domains of the glucagon-like peptide-1 receptor in ligand binding and activation
Biochem Soc Trans (2002) 30 (3): A96.
Overexpression, purification and characterisation of the N-terminal domain of the glucagon-like peptide-1 receptor
Biochem Soc Trans (2002) 30 (3): A96.
Alanine scan of the first extracellular loop of the glucagon-like peptide-1 receptor
Biochem Soc Trans (2002) 30 (3): A96.