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Volume 30, Issue 2

April 2002

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Cover Image
Front Matter
Table of Contents
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ISSN 0300-5127

EISSN 1470-8752

In this Issue

Colworth Medal Lecture
Jubilee Lecture
675th Meeting
Focused meeting

Colworth Medal Lecture

Complexities in ETS-Domain Transcription Factor Function and Regulation: Lessons from the TCF (Ternary Complex Factor) Subfamily

A. D. Sharrocks

Biochem Soc Trans (2002) 30 (2): 1–9.

Abstract

View Articletitled, Complexities in ETS-Domain Transcription Factor Function and Regulation: Lessons from the TCF (Ternary Complex Factor) Subfamily

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Jubilee Lecture

Role of Src in Signal Transduction Pathways

S. A. Courtneidge

Biochem Soc Trans (2002) 30 (2): 11–17.

Abstract

View Articletitled, Role of Src in Signal Transduction Pathways

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675th Meeting

The regulatory design of an allosteric feedback loop: the effect of saturation by pathway substrate

S. Hofmeyr Jan-Hendrik; Brett G. Olivier

Biochem Soc Trans (2002) 30 (2): 19–25.

Abstract

View Articletitled, The regulatory design of an allosteric feedback loop: the effect of saturation by pathway substrate

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Simplifying metabolic complexity

D. Brand Martin; R. Keira Curtis

Biochem Soc Trans (2002) 30 (2): 25–30.

Abstract

View Articletitled, Simplifying metabolic complexity

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Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease

Judit Oláh; Ferenc Orosz; György M. Keserü; Zoltán Kovári; János Kovács; Susan Hollán; Judit Ovádi

Biochem Soc Trans (2002) 30 (2): 30–38.

Abstract

View Articletitled, Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease

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Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

Loranne Agius; Josep Centelles; Marta Cascante

Biochem Soc Trans (2002) 30 (2): 38–43.

Abstract

View Articletitled, Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

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Stoicheiometric analysis in studies of metabolism

Athel Cornish-Bowden; Jan-Hendrik S. Hofmeyr; María Luz Cárdenas

Biochem Soc Trans (2002) 30 (2): 43–46.

Abstract

View Articletitled, Stoicheiometric analysis in studies of metabolism

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Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes

Richard N. Perham; D. Dafydd Jones; Hitesh J. Chauhan; Mark J. Howard

Biochem Soc Trans (2002) 30 (2): 47–51.

Abstract

View Articletitled, Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes

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Conversion of pancreatic cells to hepatocytes

David Tosh; Chia-Ning Shen; Jonathan M. W. Slack

Biochem Soc Trans (2002) 30 (2): 51–54.

Abstract

View Articletitled, Conversion of pancreatic cells to hepatocytes

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Calmodulin conformational changes in the activation of protein kinases

K. Török

Biochem Soc Trans (2002) 30 (2): 55–61.

Abstract

View Articletitled, Calmodulin conformational changes in the activation of protein kinases

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Sequential extracts of human bone show differing collagen synthetic rates

J. Babraj; D.J. Cuthbertson; P. Rickhuss; W. Meier-Augenstein; K. Smith; J. Bohé; R. R. Wolfe; J. N. A. Gibson; C. Adams; M. J. Rennie

Biochem Soc Trans (2002) 30 (2): 61–65.

Abstract

View Articletitled, Sequential extracts of human bone show differing collagen synthetic rates

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Introduction: the what and the how of diagnosis

M. Reay; S. Howell

Biochem Soc Trans (2002) 30 (2): 67.

View Articletitled, Introduction: the what and the how of diagnosis

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Gene-diet interaction and plasma lipid responses to dietary intervention

J. M. Ordovas

Biochem Soc Trans (2002) 30 (2): 68–73.

Abstract

View Articletitled, Gene-diet interaction and plasma lipid responses to dietary intervention

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Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays

A. J. Ricco; T. D. Boone; Z. H. Fan; I. Gibbons; T. Matray; S. Singh; H. Tan; T. Tian; S. J. Williams

Biochem Soc Trans (2002) 30 (2): 73–78.

Abstract

View Articletitled, Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays

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Exploring Nature's plasticity with a flexible probing tool, and finding new ways for its electronic distribution

M. Beier; M. Baum; H. Rebscher; R. Mauritz; A. Wixmerten; C. F. Stähler; M. Müller; P. F. Stähler

Biochem Soc Trans (2002) 30 (2): 78–82.

Abstract

View Articletitled, Exploring Nature's plasticity with a flexible probing tool, and finding new ways for its electronic distribution

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The ProteinChip^® Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation

K. Chapman

Biochem Soc Trans (2002) 30 (2): 82–87.

Abstract

View Articletitled, The ProteinChip® Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation

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Hypersensitive mousetraps, α₁-antitrypsin deficiency and dementia

D. A. Lomas; A. Lourbakos; S.-A. Cumming; D. Belorgey

Biochem Soc Trans (2002) 30 (2): 89–92.

Abstract

View Articletitled, Hypersensitive mousetraps, α1-antitrypsin deficiency and dementia

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Gene regulation of the serine proteinase inhibitors α₁-antitrypsin and α₁-antichymotrypsin

N. Kalsheker; S. Morley; K. Morgan

Biochem Soc Trans (2002) 30 (2): 93–98.

Abstract

View Articletitled, Gene regulation of the serine proteinase inhibitors α1-antitrypsin and α1-antichymotrypsin

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Proteinases in chronic obstructive pulmonary disease

S. D. Shapiro

Biochem Soc Trans (2002) 30 (2): 98–102.

Abstract

View Articletitled, Proteinases in chronic obstructive pulmonary disease

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Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen

E. Stringa; D. White; R. S. Tuan; V. Knauper; J. Gavrilovic

Biochem Soc Trans (2002) 30 (2): 102–107.

Abstract

View Articletitled, Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen

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Modulation of extracellular matrix using adenovirus vectors

C. D. Richards; C. Kerr; L. Tong; C. Langdon

Biochem Soc Trans (2002) 30 (2): 107–111.

Abstract

View Articletitled, Modulation of extracellular matrix using adenovirus vectors

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Antimicrobial activity of antiproteinases

J.-M. Sallenave

Biochem Soc Trans (2002) 30 (2): 111–115.

Abstract

View Articletitled, Antimicrobial activity of antiproteinases

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Novel roles of protease inhibitors in infection and inflammation

P. S. Hiemstra

Biochem Soc Trans (2002) 30 (2): 116–120.

Abstract

View Articletitled, Novel roles of protease inhibitors in infection and inflammation

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Statins for the prevention of vein graft stenosis: a role for inhibition of matrix metalloproteinase-9

K. E. Porter; N. A. Turner

Biochem Soc Trans (2002) 30 (2): 120–126.

Abstract

View Articletitled, Statins for the prevention of vein graft stenosis: a role for inhibition of matrix metalloproteinase-9

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Role of plasminogen activators in peritoneal adhesion formation

H. Sulaiman; L. Dawson; G. J. Laurent; G. J. Bellingan; S. E. Herrick

Biochem Soc Trans (2002) 30 (2): 126–131.

Abstract

View Articletitled, Role of plasminogen activators in peritoneal adhesion formation

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Functions and interplay of the tRNA-binding sites of the ribosome

V. Márquez; D. N. Wilson; K. H. Nierhaus

Biochem Soc Trans (2002) 30 (2): 133–140.

Abstract

View Articletitled, Functions and interplay of the tRNA-binding sites of the ribosome

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The hepatitis C virus internal ribosome-entry site: a new target for antiviral research

J. Gallego; G. Varani

Biochem Soc Trans (2002) 30 (2): 140–145.

Abstract

View Articletitled, The hepatitis C virus internal ribosome-entry site: a new target for antiviral research

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Splicing signals and factors in plant intron removal

J. W. S. Brown; C. G. Simpson; G. Thow; G. P. Clark; S. N. Jennings; N. Medina-Escobar; S. Haupt; S. C. Chapman; K. J. Oparka

Biochem Soc Trans (2002) 30 (2): 146–149.

Abstract

View Articletitled, Splicing signals and factors in plant intron removal

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The Escherichia coli RNA degradosome: structure, function and relationship to other ribonucleolytic multienyzme complexes

A. J. Carpousis

Biochem Soc Trans (2002) 30 (2): 150–155.

Abstract

View Articletitled, The Escherichia coli RNA degradosome: structure, function and relationship to other ribonucleolytic multienyzme complexes

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Translation initiation and surface plasmon resonance: new technology applied to old questions

T. von der Haar; J. M. X. Hughes; M. Manjurul Karim; M. Ptushkina; J. E. G. McCarthy

Biochem Soc Trans (2002) 30 (2): 155–162.

Abstract

View Articletitled, Translation initiation and surface plasmon resonance: new technology applied to old questions

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Extracellular proteolysis in the development and progression of atherosclerosis

H. R. Lijnen

Biochem Soc Trans (2002) 30 (2): 163–167.

Abstract

View Articletitled, Extracellular proteolysis in the development and progression of atherosclerosis

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Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation

T. Chavakis; S. M. Kanse; A. E. May; K. T. Preissner

Biochem Soc Trans (2002) 30 (2): 168–173.

Abstract

View Articletitled, Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation

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Mechanism of thrombin-induced angiogenesis

M. E. Maragoudakis; N. E. Tsopanoglou; P. Andriopoulou

Biochem Soc Trans (2002) 30 (2): 173–177.

Abstract

View Articletitled, Mechanism of thrombin-induced angiogenesis

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Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

M. Ploug; H. Gårdsvoll; T. J. D. Jørgensen; L. Lønborg Hansen; K. Danø

Biochem Soc Trans (2002) 30 (2): 177–183.

Abstract

View Articletitled, Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

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Tissue plasminogen activator as a key effector in neurobiology and neuropathology

T. Teesalu; A. Kulla; T. Asser; M. Koskiniemi; A. Vaheri

Biochem Soc Trans (2002) 30 (2): 183–189.

Abstract

View Articletitled, Tissue plasminogen activator as a key effector in neurobiology and neuropathology

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Cellular mechanisms regulating non-haemostatic plasmin generation

R. Bass; V. Ellis

Biochem Soc Trans (2002) 30 (2): 189–194.

Abstract

View Articletitled, Cellular mechanisms regulating non-haemostatic plasmin generation

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Coagulation cascade proteases and tissue fibrosis

R. C. Chambers; G. J. Laurent

Biochem Soc Trans (2002) 30 (2): 194–200.

Abstract

View Articletitled, Coagulation cascade proteases and tissue fibrosis

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Coagulation proteases and human cancer

M. T. Sampson; A. K. Kakkar

Biochem Soc Trans (2002) 30 (2): 201–207.

Abstract

View Articletitled, Coagulation proteases and human cancer

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Urokinase-type plasminogen activator: a potent marker of metastatic potential in human cancers

M. J. Duffy

Biochem Soc Trans (2002) 30 (2): 207–210.

Abstract

View Articletitled, Urokinase-type plasminogen activator: a potent marker of metastatic potential in human cancers

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Role of thrombin and its major cellular receptor, protease-activated receptor-I, in pulmonary fibrosis

D. C. Howell; G. J. Laurent; R. C. Chambers

Biochem Soc Trans (2002) 30 (2): 211–216.

Abstract

View Articletitled, Role of thrombin and its major cellular receptor, protease-activated receptor-I, in pulmonary fibrosis

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Inhibition of tissue factor activity reduces the density of cellular network formation in an in vitro model of angiogenesis

N. J. James; C. Ettelaie; K. R. Bruckdorfer

Biochem Soc Trans (2002) 30 (2): 217–221.

Abstract

View Articletitled, Inhibition of tissue factor activity reduces the density of cellular network formation in an in vitro model of angiogenesis

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Tissue plasminogen activator as a modulator of neuronal survival and function

S. E. Tsirka

Biochem Soc Trans (2002) 30 (2): 222–225.

Abstract

View Articletitled, Tissue plasminogen activator as a modulator of neuronal survival and function

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Energetics of muscle contraction: the whole is less than the sum of its parts

M. J. Kushmerick; K. E. Conley

Biochem Soc Trans (2002) 30 (2): 227–231.

Abstract

View Articletitled, Energetics of muscle contraction: the whole is less than the sum of its parts

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Evolving techniques for the investigation of muscle bioenergetics and oxygenation

R. S. Richardson; E. A. Noyszewski; L. J. Haseler; S. Bluml; L. R. Frank

Biochem Soc Trans (2002) 30 (2): 232–237.

Abstract

View Articletitled, Evolving techniques for the investigation of muscle bioenergetics and oxygenation

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Exertional oxygen uptake kinetics: a stamen of stamina?

B. J. Whipp; H. B. Rossiter; S. A. Ward

Biochem Soc Trans (2002) 30 (2): 237–247.

Abstract

View Articletitled, Exertional oxygen uptake kinetics: a stamen of stamina?

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Measuring real levels of oxygen in vivo: opportunities and challenges

H. M. Swartz

Biochem Soc Trans (2002) 30 (2): 248–252.

Abstract

View Articletitled, Measuring real levels of oxygen in vivo: opportunities and challenges

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Mitochondrial respiration at low levels of oxygen and cytochrome c

E. Gnaiger; A. V. Kuznetsov

Biochem Soc Trans (2002) 30 (2): 252–258.

Abstract

View Articletitled, Mitochondrial respiration at low levels of oxygen and cytochrome c

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Lactate shuttles in Nature

G. A. Brooks

Biochem Soc Trans (2002) 30 (2): 258–264.

Abstract

View Articletitled, Lactate shuttles in Nature

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Different modes of activating phosphofructokinase, a key regulatory enzyme of glycolysis, in working vertebrate muscle

G. Wegener; U. Krause

Biochem Soc Trans (2002) 30 (2): 264–270.

Abstract

View Articletitled, Different modes of activating phosphofructokinase, a key regulatory enzyme of glycolysis, in working vertebrate muscle

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Adipose tissue, the immune system and exercise fatigue: how activated lymphocytes compete for lipids

C. M. Pond

Biochem Soc Trans (2002) 30 (2): 270–275.

Abstract

View Articletitled, Adipose tissue, the immune system and exercise fatigue: how activated lymphocytes compete for lipids

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An acetyl group deficit limits mitochondrial ATP production at the onset of exercise

P. L. Greenhaff; S. P. Campbell-O'Sullivan; D. Constantin-Teodosiu; S. M. Poucher; P. A. Roberts; J. A. Timmons

Biochem Soc Trans (2002) 30 (2): 275–280.

Abstract

View Articletitled, An acetyl group deficit limits mitochondrial ATP production at the onset of exercise

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Exercise, free radicals and oxidative stress

C. E. Cooper; N. B. J. Vollaard; T. Choueiri; M. T. Wilson

Biochem Soc Trans (2002) 30 (2): 280–285.

Abstract

View Articletitled, Exercise, free radicals and oxidative stress

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Gene expression in skeletal muscle

G. Goldspink

Biochem Soc Trans (2002) 30 (2): 285–290.

Abstract

View Articletitled, Gene expression in skeletal muscle

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Structural enzymology of carbohydrate-active enzymes: implications for the post-genomic era

G. J. Davies; B. Henrissat

Biochem Soc Trans (2002) 30 (2): 291–297.

Abstract

View Articletitled, Structural enzymology of carbohydrate-active enzymes: implications for the post-genomic era

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Genetic dissection of plant cell-wall biosynthesis

D. T. Bonetta; M. Facette; T. K. Raab; C. R. Somerville

Biochem Soc Trans (2002) 30 (2): 298–301.

Abstract

View Articletitled, Genetic dissection of plant cell-wall biosynthesis

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A multigene family of glycosyltransferases in a model plant, Arabidopsis thaliana

D. Bowles

Biochem Soc Trans (2002) 30 (2): 301–306.

Abstract

View Articletitled, A multigene family of glycosyltransferases in a model plant, Arabidopsis thaliana

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Focused meeting

Role of AMP-activated protein kinase in the regulation of gene transcription

I. Leclerc; B. Viollet; G. da Silva Xavier; A. Kahn; G. A. Rutter

Biochem Soc Trans (2002) 30 (2): 307–311.

Abstract

View Articletitled, Role of AMP-activated protein kinase in the regulation of gene transcription

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Short-term regulation of insulin gene transcription

B. Leibiger; T. Moede; S. Uhles; P.-O. Berggren; I. B. Leibiger

Biochem Soc Trans (2002) 30 (2): 312–317.

Abstract

View Articletitled, Short-term regulation of insulin gene transcription

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Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function

R. N. Kulkarni

Biochem Soc Trans (2002) 30 (2): 317–322.

Abstract

View Articletitled, Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function

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Structure-function relationships in the β-cell K_ATP channel

M. V. Mikhailov; E. A. Mikhailova; S. J. H. Ashcroft

Biochem Soc Trans (2002) 30 (2): 323–327.

Abstract

View Articletitled, Structure-function relationships in the β-cell KATP channel

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Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in β-cells

A. Varadi; E. K. Ainscow; V. J. Allan; G. A. Rutter

Biochem Soc Trans (2002) 30 (2): 328–332.

Abstract

View Articletitled, Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in β-cells

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Pharmacological modulation of K_ATP channels

F. M. Gribble; F. Reimann

Biochem Soc Trans (2002) 30 (2): 333–339.

Abstract

View Articletitled, Pharmacological modulation of KATP channels

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