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October 2001
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
674th Trinity College, Dublin Signalling Homeostasis
Keilin's cytochromes: how bacteria vary them, use them and make them
Biochem Soc Trans (2001) 29 (5): A91.
DNA Damage Signalling and Apoptosis
Pathogen-derived immunomodulatory molecules - the bridge between innate and adaptive immunity
Biochem Soc Trans (2001) 29 (5): A92.
ATM: genome stability, neuronal development and cancer cross paths
Biochem Soc Trans (2001) 29 (5): A92.
Choosing between growth arrest and apoptosis through RB, Ab1 and p73
Biochem Soc Trans (2001) 29 (5): A92.
DNA damage signalling and NFκB: mechanisms of activation and implications for death
Biochem Soc Trans (2001) 29 (5): A92.
Uncovering BRCA1 regulated signalling pathways by microarray based expression profiling
Biochem Soc Trans (2001) 29 (5): A93.
Secondary DNA structures as molecular targets for cancer therapeutics
Biochem Soc Trans (2001) 29 (5): A93.
Caspase activation and effector function during the demolition phase of apoptosis
Biochem Soc Trans (2001) 29 (5): A94.
Pyrrolo-1,5-benzoxazepines: A new class of apoptotic agents
P.M. Zisterer; M.M. McGee; G. Campiani; A. Rumunno; C. Fattorusso; V. Nacci; M. Lawler; D.C. Williams
Biochem Soc Trans (2001) 29 (5): A94.
Oncogenes, apoptosis and cancer, with special emphasis on p53 and c-Myc
Biochem Soc Trans (2001) 29 (5): A94.
Neurotransmitter Transporters: Molecular Mechanism and Regulation
Molecular characterisation of substrate binding sites in the glutamate transporter family
Biochem Soc Trans (2001) 29 (5): A95.
Molecular cloning and characterization of hemicholinium-3-sensitive choline transporters
Biochem Soc Trans (2001) 29 (5): A95.
SERT biosynthesis and the problems of overexpression for structural studies
Biochem Soc Trans (2001) 29 (5): A95.
Regulation of the serotonin transporter by interacting proteins
Biochem Soc Trans (2001) 29 (5): A96.
On the structure, function and regulation of the serotonin transporter
Biochem Soc Trans (2001) 29 (5): A96.
The impact of oligomerization on the function of the serotonin transporter
Biochem Soc Trans (2001) 29 (5): A96.
Up, down, fast, slow, here and there: Regulating GABA transporter function
Biochem Soc Trans (2001) 29 (5): A96.
Molecular determinants involved in the asymmetrical distribution of glycine transporters in polarised cells
Biochem Soc Trans (2001) 29 (5): A97.
Mitochondrial Uncoupling Proteins
Life without UCP1
Jan Nedergaard; Valeria Golozoubova; Anita Matthias; Irina G. Shabalina; Anders Jacobsson; Barbara Cannon
Biochem Soc Trans (2001) 29 (5): A97.
The function of UCP1 homologues
M.D. Brand; M.B. Jekabsons; D. Roussel; J. St-Pierre; S. Cadenas; J.C. Clapham; J.A. Harper; J.A. Stuart; K. Echtay
Biochem Soc Trans (2001) 29 (5): A98.
Ucp3 expression and function:Studies in transgenic mice and human muscle
Biochem Soc Trans (2001) 29 (5): A98.
UCP2 is a negative regulator of glucose-stimulated insulin secretion
Biochem Soc Trans (2001) 29 (5): A99.
The control of transport in the uncoupling proteins UCP1 and UCP2
Biochem Soc Trans (2001) 29 (5): A101.
Signal Transduction During Innate and Adaptive Immunity
The Toll receptors and the antimicrobial defenses of drosophila
Biochem Soc Trans (2001) 29 (5): A101.
Dimerization of the CD45 RPTPase inhibits its function in vivo and is necessary in order to prevent autoimmunity
Biochem Soc Trans (2001) 29 (5): A102.
Visualizing the spatial and temporal orchestration of T cell activation
Biochem Soc Trans (2001) 29 (5): A102.
Vav1 transduces TCR signals modulating lymphocyte adhesion and morphology
Biochem Soc Trans (2001) 29 (5): A103.
Signal transduction downstrean of PI 3-kinase
Ricardo M. Biondi; Maria Deak; Simon Dowler; Wendy Kimber; Margaret Lawlor; Christine Thomas; Daan Van Aalton; Dario R. Alessi
Biochem Soc Trans (2001) 29 (5): A104.
SOCS proteins - negative regulators of the cytokine signal transduction
Biochem Soc Trans (2001) 29 (5): A105.
Teaching Practical Skills to 21st Century Biochemists
Acquiring the right techniques for biomedical analyst and clinical chemistry
Biochem Soc Trans (2001) 29 (5): A106.
Training the next Generation of Biochemists - Projects, Posters and Posters
Biochem Soc Trans (2001) 29 (5): A106.
Practical Molecular Biology - large numbers on a small budget, a 21st-century paradox?
Biochem Soc Trans (2001) 29 (5): A107.
Specialist and refresher courses for the practising biochemist: the importance of continuing education
Biochem Soc Trans (2001) 29 (5): A107.
Enzymes That Regulate Lipid Metabolism In Cell Signalling
Regulation of de novo sphingolipid biosynthesis: A necessary but dangerous pathway
Biochem Soc Trans (2001) 29 (5): A108.
Regulation of phospholipase C-γ2 and phosphoinositide 3-kinase pathways by adaptor molecules in B lymphocytes
Biochem Soc Trans (2001) 29 (5): A109.
Signalling via PI3-kinases
P.T. Hawkins; L. Stephens; H. Welch; C. Ellson; S. Gobert; A.B. Holmes; J.W. Thuring; M.A. Cooper; Z-Y Lim; P. Tempst; H. Erdjument-Bromage; A. Grewal
Biochem Soc Trans (2001) 29 (5): A109.
Functional antagonism of PI 3-kinase signalling by the tumour suppressor protein, PTEN
Biochem Soc Trans (2001) 29 (5): A109.
Type I Interferon Inhibit Neutrophil Apoptosis via a PI-3 kinase Dependent Signaling Pathway
Biochem Soc Trans (2001) 29 (5): A110.
Xanthine oxidoreductase activity in synovial fluid from patients with rheumatoid arthritis
Biochem Soc Trans (2001) 29 (5): A110.
Generation of a plant polypeptide library and screening with a 3D skin model
Biochem Soc Trans (2001) 29 (5): A111.
Cloning, characterisation and analysis of endonuclease V from three different classes of bacteria
Biochem Soc Trans (2001) 29 (5): A111.
Peptides from seminal plasma causing cell death in immune-based cell lines
Biochem Soc Trans (2001) 29 (5): A112.
Expression and localisation of a CLIC (Chloride Intracellular Channel) protein fused to green fluorescent protein
Biochem Soc Trans (2001) 29 (5): A112.
Relationship between variable Bcr-Abl expression levels and drug resistance: Role of AKT/Protein Kinase B pathway
Biochem Soc Trans (2001) 29 (5): A112.
The role of tyrosine phosphorylation in TNFα-induced apoptosis of Human Umbilical Vein Endothelial Cells (HUVECs)
Biochem Soc Trans (2001) 29 (5): A113.
The two-stage evolution of homochirality: From sugars to protein via RNA
Biochem Soc Trans (2001) 29 (5): A113.
Fenretinide-induced cell death in epidermoid carcinoma is augmented by nifedipine
Biochem Soc Trans (2001) 29 (5): A113.
Regulation of p300/CBP activity by the CDK inhibitor p21WAF1/CIP1
Biochem Soc Trans (2001) 29 (5): A113.
Stability of beta glucanase under conditions simulating the digestive tract
Biochem Soc Trans (2001) 29 (5): A114.
Purification and characterisation of phytase from Aspergillus niger ATCC 9142
Biochem Soc Trans (2001) 29 (5): A115.
Studies on induction of differentiation in mouse embryonic stem cells using retinoic acid and dimethyl sulphoxide
Biochem Soc Trans (2001) 29 (5): A115.
The neuronal apoptosis inhibitory protein (NAIP) is a membrane-associated cytoplasmic protein in rabbit brain
Biochem Soc Trans (2001) 29 (5): A116.
The effects of protein kinase inhibitors on Type I diabetic serum-induced BRIN BD11 pancreatic beta-cell cytotoxicity
Biochem Soc Trans (2001) 29 (5): A116.
DNA damage in human sperm using alkaline and neutral Comet assays
Biochem Soc Trans (2001) 29 (5): A116.
A human cell culture system for studying post-translational regulation of p53 at physiological levels
Biochem Soc Trans (2001) 29 (5): A116.
Transient Jun N-terminal kinase (JNK) activation and suppression of apoptosis by IGF-I
Biochem Soc Trans (2001) 29 (5): A117.
The type of cell death induced by MPP+ is both concentration and time dependant
Biochem Soc Trans (2001) 29 (5): A117.
Domain requirements for IGF-1 receptor and insulin receptor tyrosine kinase activity
Biochem Soc Trans (2001) 29 (5): A117.
Impairments in IGF-1-PKB signal transduction in Alzheimer's disease brain
Biochem Soc Trans (2001) 29 (5): A118.
Specificity of arachidonic acid-induced growth inhibition in Chronic Myeloid Leukemia
Biochem Soc Trans (2001) 29 (5): A118.
Vav1 is required for platelet aggregation to threshold concentrations of Glycoprotein VI agonist, independent of phospholipase C and Rac
Biochem Soc Trans (2001) 29 (5): A118.
Characterisation of Phenylalanine Dehydrogenase with chemically synthesised non-natural amino acids
Biochem Soc Trans (2001) 29 (5): A119.
Examination of coenzyme specificity in Clostridial glutamate dehydrogenase by site-directed mutagenesis
Biochem Soc Trans (2001) 29 (5): A119.
RT-PCR evidence for the expression of UCP-2 in Spleen and a murine macrophage cell line (J774)
Biochem Soc Trans (2001) 29 (5): A119.
Artefactual uncoupling following UCP3 expression in yeast mitochondria
Biochem Soc Trans (2001) 29 (5): A120.
Discriminatory antibody raised to UCP-3 used to detect protein in a number of systems
Biochem Soc Trans (2001) 29 (5): A120.
Skeletal Muscle Uncoupling Protein 3 Expression Following Endurance Swimming Training in Mice
Biochem Soc Trans (2001) 29 (5): A120.
UCP2, expressed at endogenous levels, mediates mitochondrial proton leak in mammalian cells
Biochem Soc Trans (2001) 29 (5): A120.
Relationship between uncoupling proteins and mitochondrial proton leak in multiple tissues of arctic ground squirrels
Biochem Soc Trans (2001) 29 (5): A121.
Effect of chronic leptin administration on UCP1 expression in neonatal lambs
Biochem Soc Trans (2001) 29 (5): A121.
Development of a hybrid protein to study the 3D structure of UCP1 matrix loops
Biochem Soc Trans (2001) 29 (5): A122.
Uncoupling protein 2 expression and coenzyme Q content of spleen and lung-effects of neonatal endotoxaemia
Biochem Soc Trans (2001) 29 (5): A122.
Effects of maternal nutrient restriction on ovine fetal uncoupling protein-1 expression
Biochem Soc Trans (2001) 29 (5): A122.
Towards the identification of the retinoid binding site in the uncoupling protein UCP1
Biochem Soc Trans (2001) 29 (5): A122.
Systematic investigation of the second repeat of the uncoupling protein UCP1 by replacement with divergent UCP2 motifs
Biochem Soc Trans (2001) 29 (5): A123.
The effect of Y253F on the activity of the plant alternative oxidase in Schizosaccharomyces pombe mitochondria
Biochem Soc Trans (2001) 29 (5): A123.
Rat muscle mitochondria treated with dowex are GDP insensitive
Biochem Soc Trans (2001) 29 (5): A123.
The study of a therapeutically important proline-specific peptidase from bovine serum
Biochem Soc Trans (2001) 29 (5): A124.
Rapid homology modelling of membrane transport proteins and receptors
Biochem Soc Trans (2001) 29 (5): A124.
Modulation of the serotonin transporter by membrane cholesterol
Biochem Soc Trans (2001) 29 (5): A124.
Regulation of rat hepatic phenylalanine hydroxylation system in vivo
Biochem Soc Trans (2001) 29 (5): A124.
Amino acid sequencing and possible cloning of a new proline specific peptidase from bovine serum
Biochem Soc Trans (2001) 29 (5): A125.
Glutamate dehydrogenase from the halophilic organism Halobacterium halobium
Biochem Soc Trans (2001) 29 (5): A125.
A family of proteins related to spatzle, the Tol receptor ligand are encoded in the Drosophila genome
Biochem Soc Trans (2001) 29 (5): A126.
Requirement for CD28 co-stimulation is lower in SHP-1 deficient T cells
R.J. Matthews; J.G. Sathish; K.G. Johnson; E.G. LeRoy; K.J. Fuller; M.B. Hallett; P. Brennan; L.K. Borysiewicz; M.J. Sims
Biochem Soc Trans (2001) 29 (5): A126.
Signal transduction mechanisms generating T-cell leukaemias in CD45-deficient mutant Lck mice
Biochem Soc Trans (2001) 29 (5): A126.
The tyrosine phosphatase, SHP-1, modulates proliferation and apoptotic responses in the interleukin-3 dependant cell line Ba/F3
Biochem Soc Trans (2001) 29 (5): A126.
Antithrombin III and hirudin inhibits LPS-mediated NF-κB activation
Biochem Soc Trans (2001) 29 (5): A127.
CD28 upregulates expression of EphA3 in Jurkat cells through the IGF-I receptor
Biochem Soc Trans (2001) 29 (5): A127.
Regulation of IL-1 induced NF-κB signalling by Tollip involves both receptor complex components TRAF6 and MyD88
Biochem Soc Trans (2001) 29 (5): A127.
Tumor-expressed Fas ligand suppresses IL-2 production in tumor-infiltrating lymphocytes
Biochem Soc Trans (2001) 29 (5): A127.
Oxidation decreases the anti-inflammatory activity of secretory leucoprotease inhibitor
Biochem Soc Trans (2001) 29 (5): A128.
The Jurkat cell line has constitutively active PI3K/PKB SIgnalling: effect of inducible expression of a membrane-localised SHIP construct
Biochem Soc Trans (2001) 29 (5): A128.
GPVI signalling in glycosphingolipid enriched membrane domains (GEMs)
Biochem Soc Trans (2001) 29 (5): A129.
Acylation of Lysophosphatidylcholine is Crucial to the Monocyte Response to LPS
Biochem Soc Trans (2001) 29 (5): A129.
Vav-2 signalling participates in the humoral immune response and B cell maturation
Biochem Soc Trans (2001) 29 (5): A129.
Activity and regulation of human MBL associated serine protease1(MASP-1)
Biochem Soc Trans (2001) 29 (5): A129.
Regulation of the expression of NRD-Convertase: a novel promoter element
Biochem Soc Trans (2001) 29 (5): A130.
Activation of NFκB by IL1 and TNFα in human endometrial cells
Biochem Soc Trans (2001) 29 (5): A130.
The putative GTPase activating protein IIP-1 functions antagonistically to Ras in the regulation of Interleukin-1 signalling
Biochem Soc Trans (2001) 29 (5): A130.
Role of the cytoplasmic tyrosine phosphatase SHP-2 in haemopoietic cells following IL-3 stimulation
Biochem Soc Trans (2001) 29 (5): A130.
The IL1 receptor homologue T1/ST2 activates MAP kinases and AP1 but not NF-kappaB
Biochem Soc Trans (2001) 29 (5): A131.
The role of PI3-kinase in IL-3-mediated proliferation and cell cycle progression
Biochem Soc Trans (2001) 29 (5): A131.
PI 3-kinase-dependent pathways to NF-κB activation in primary B cells
Biochem Soc Trans (2001) 29 (5): A132.
Mal (MyD88 adapter-like) is a novel Toll IL-1 receptor (TIR) domain-containing adapter which recruits IRAK-2 during Toll-like receptor-4 signal transduction
K.A. Fitzgerald; A.G. Bowie; E.M. Palsson-McDermott; A. Dunne; P. Gray; M.T. Harte; C.A. Jefferies; A.S. Mansell; D. McMurray; D.E. Smith; J.E. Sims; T.A. Bird; L.A.J. O'Neill
Biochem Soc Trans (2001) 29 (5): A132.
CXCR3-mediated signal transduction events in T-blasts in response to IP-10 and ITAC stimulation
Biochem Soc Trans (2001) 29 (5): A132.
Signal Transduction Pathways Mediated by the Nucleophosmin-Anaplastic Lymphoma Kinase
Biochem Soc Trans (2001) 29 (5): A133.
Investigation into the activation status of PKC isoforms β1, δ and θ in a Jurkat T cell line using phospho-specific antibodies
Biochem Soc Trans (2001) 29 (5): A133.
Regulation of IκBα through phosphorylation dependent high affinity NF-κB interactions
Biochem Soc Trans (2001) 29 (5): A133.
CCR4-mediated signal transduction events in CCR4 transfected CHO cells in response to MDC stimulation
Biochem Soc Trans (2001) 29 (5): A134.
Dichloropropionanilide (DCPA) down regulates T cell IL-2 production by interfering with the binding of key transcription factors
Biochem Soc Trans (2001) 29 (5): A134.
Bovine spleen cathepsin B: presence and properties of the isozymic components
Biochem Soc Trans (2001) 29 (5): A134.
Training the next Generation of Biochemists - Projects, Posters and Posters
Biochem Soc Trans (2001) 29 (5): A135.
