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October 2000
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
Satellite Meeting of the 18th International Congress of Biochemistry and Molecular Biology
Gene Action and Cellular Function in Parasitic Protozoa
Genomic organization and gene function in Leishmania
P. J. Myler; E. Sisk; P. D. McDonagh; S. Martinez-Calvillo; A. Schnaufer; S. M. Sunkin; S. Yan; R. Madhubala; A. Ivens; K. Stuart
Biochem Soc Trans (2000) 28 (5): 527–531.
Life-cycle differentiation in Trypanosoma brucei: molecules and mutants
Biochem Soc Trans (2000) 28 (5): 531–536.
Innate Immunity
The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence
Biochem Soc Trans (2000) 28 (5): 557–563.
18th International Congress of Biochemistry and Molecular Biology
THE SEVERO OCHOA LECTURE
THE KUNIO YAGI LECTURE
THE EMBO LECTURE
THE E.C. SLATER LECTURE
THE OSAMU HAYAISHI LECTURE
THE PABMB LECTURE
THE CHESTER BEATTY LECTURE
The Bcl-2 Family: Arbiters of Life and Death
S. Cory; D. C. S. Huang; C. G. Print; K. Moriishi; P. Bouillet; L. A. O'reilly; H. Puthalakath; S. Ogilvy; L. O'connor; M. L. Bath; G. Hausmann; D. Metcalf; A. W. Harris; J. M. Adams
Biochem Soc Trans (2000) 28 (5): A98.
THE DATTA LECTURE
CONTROL OF METABOLIC PATHWAYS
Flexibility the network for high-energy phosphoryl (ATP) transfer in mammalian cells
B. Wieringa; R.i n't Zandt; A. Heerschap; A. de Groof; E. Janssen; I. van der Zee; C. Jost; F. Oerlemans
Biochem Soc Trans (2000) 28 (5): A99.
Metabolic regulatory mechanisms in liver and pancreatic islets revealed by genetic engineering
Biochem Soc Trans (2000) 28 (5): A99.
The role of the subcellular compartmentation of glucokinase in control of hepatic glucose metabolism
Biochem Soc Trans (2000) 28 (5): A100.
ELECTRONlPROTON COUPLING IN RESPIRATORY COMPLEXES
The ins and outs of electrons and protons in cytochrome c oxidase
S. Ferguson-MiHer; Y. Zhen; F. Millett; V. Robertss; M. Pique; Kefei Wang; Yasmin Hilmi; L. Geren; J. Yang; C. Hoganson; G. Babcock
Biochem Soc Trans (2000) 28 (5): A100.
GENE INTEGRITY: DNA REPAIR
The repair of double-strand breaks in human cells
S. C. West; A. Baillot; C. Chappell; A. Constantinou; A. Davies; E. Van Dyck; L. Hanakahi; J. Y. Masson; M. McIlwraith; C. A. Parsons; M. Tarsounas
Biochem Soc Trans (2000) 28 (5): A101.
GENOMES AND THEIR ANALYSIS
MOLECULAR ASSEMBLIES: THE RIBOSOME
Structural studies on ribosomal components - insights into the mechanism of translation
Biochem Soc Trans (2000) 28 (5): A103.
The complete structure of the 50S ribosomal subunit and a substrate complex
Biochem Soc Trans (2000) 28 (5): A103.
MOLECULAR BASIS OF COMPLEX DISORDERS
Molecular Pathogenesis of Type 2 Diabetes Mellitus and Obesity in Knockout Mice Models
Biochem Soc Trans (2000) 28 (5): A104.
Familial Hypertrophic Cardiomyopathy in Mice and Men
J. G. Seidman; C. Semsarian; B. K. McConnell; D. Fatkin; J. Mudd; I. Moskowitz; F. Schoen; M. Giewat; C. Seidman
Biochem Soc Trans (2000) 28 (5): A104.
TRANSCRIPTION ACTIVATION AND REPRESSION MECHANISMS
Structure of the Histone Acetyltransferase Domains of the GCN5, P/CAF and ESA1 Transcriptional Coactivators
J. R. Rojas; Y. Yan; R. C. Trievel; A. Clements; J. Zhou; N. Barlev; W. Lo; D. Sterner; L. Wang; S. L. Berger; C. D. Allis; R. Marmorstein
Biochem Soc Trans (2000) 28 (5): A106.
ANALYSIS AND DESIGN OF METABOLIC CONTROL
Making sense of the cellular economy and its regulation: a framework for biotechnological manipulation
Biochem Soc Trans (2000) 28 (5): A106.
COMPARATIVE AND EVOLUTIONARY GENOMICS
GENE INTEGRITY: CELL CYCLE AND TELOMERE MAINTENANCE
MOLECULAR ASSEMBLIES: HEALTH AND DISEASE
Pathway of tau aggregation into Alzheimer paired helical filaments
Biochem Soc Trans (2000) 28 (5): A108.
PROTON TRANSLOCATION MECHANISM
Time-resolved observation of proton transfer reactions across and along energy-transducing membranes
Biochem Soc Trans (2000) 28 (5): A110.
Innovation and infomation technology in teaching
From the blackboard to cyberspace: keeping up to date with the changes when teaching Biochemistry and Molecular Biology
Biochem Soc Trans (2000) 28 (5): A111.
BIOCHEMICAL AND GENETICAL ANALYSIS OF PARASITE FUNCTIONS
Pro-inflammatory activity of protozoan derived GPI-anchors and its potential role in the genesis of myocarditis induced by Trypanosoma cruzi
Biochem Soc Trans (2000) 28 (5): A111.
Beyond the genome of Plasmodium falciparum: a new balance between challenges and opportunities towards disease control
Biochem Soc Trans (2000) 28 (5): A112.
Reverse genetic approaches to metabolism, metabolic compartmentation and drug targets in trypanosomes
Biochem Soc Trans (2000) 28 (5): A112.
FUNCTIONAL GENOMICS
GENE REGULATION VIA CHROMATIN RESTRUCTURING
Global role for chromatin remodeling enzymes in mitotic gene expression
Biochem Soc Trans (2000) 28 (5): A113.
INNATE RECOGNITION AND THE IMMUNE RESPONSE
MHC CLASS I-SPECIFIC INHIBITORY RECEPTORS EXPRESSED BY NK AND T LYMPHOCYTES
Biochem Soc Trans (2000) 28 (5): A114.
Regulation of the interferon system and immune responses by the IRF family transcription factors
Biochem Soc Trans (2000) 28 (5): A114.
MOLECULAR ASPECTS OF CANCER
MOLECULAR BASIS OF VESICULAR TRAFFICKING AND TRANSMEMBRANE TRANSLOCATION
HOST-PARASITE SURFACES AND INTERFACES
Molecular interactions involved in red cell invasion by malaria parasites
Biochem Soc Trans (2000) 28 (5): A116.
MEMBRANE PROTEIN TRANSLOCATION AND PATHOGENICITY
Cell trafficking alterations caused by the H. pylori VacA toxin
Biochem Soc Trans (2000) 28 (5): A117.
MOLECULAR ASSEMBLIES: THE CYTOSKELETON
MOLECULAR ASSEMBLIESTHE CYTOSKELETON
SIGNALLING TO TRANSCRIPTION FACTORS
SIGNALING TO CHROMATIN: FROM CELL PROLIFERATION TO PHYSIOLOGICAL RESPONSES
Biochem Soc Trans (2000) 28 (5): A118.
Signalling to the nucleus by TGF-β family members and regulation of transcription
Biochem Soc Trans (2000) 28 (5): A119.
T-CELL ACTIVATION: RECOGNITION IN THE ADAPTIVE RESPONSE
Recognition of non-peptide antigens and the role of human gamma delta T-cells in innate and adaptive immunity
Biochem Soc Trans (2000) 28 (5): A119.
THE PROTEOME AND BEYOND
Defining gene function via the mass spectrometric analysis of multiprotein complexes
Biochem Soc Trans (2000) 28 (5): A120.
The problems of chemistry and metabolism
Teaching Biochemistry and Molecular Biology: new approaches for students with a poor background in Chemistry
Biochem Soc Trans (2000) 28 (5): A121.
APPLICATION AND EXPLOITATION OF SYSTEMS APPROACHES TO GENE FUNCTION
ENZYME CATALYSIS
GLYCOSYLATION AND PROTEIN FOLDING IN THE ENDOPLASMIC RETICULUM
Folding and activity of glycoenzymes is dependent on the lectins calnexin and calreticulin
Biochem Soc Trans (2000) 28 (5): A124.
NEW TECHNOLOGIES: GENOMICS AND PROTEOMICS
PROTEOMICS: AUTOMATED IDENTIFICATION OF PEPTIDES AND PROTEINS AT THE ATTOMOLE LEVEL IN COMPLEX MIXTURES MY MASS SPECTROMETRY
Biochem Soc Trans (2000) 28 (5): A124.
Microarrays of Gel Immobilized Compounds: Massive Parallel Analyses of Specific Interactions and Chemical and Enzymatic Reactions
Biochem Soc Trans (2000) 28 (5): A125.
PROTEIN MODIFICATION AND NEURAL DISORDER
The Molecular Basis of Huntington's Disease and Polyglutamine Disorders
C. Benn; D. Hay; E. Hockly; R. Gonitel; J-C. Lievens; A. Mahal; K. Sathasivam; O. Spasic-Boskovic; D. Smith; B. Woodman; G. Bates
Biochem Soc Trans (2000) 28 (5): A125.
PROTEIN TARGETING AND ORGANELLE BIOGENESIS
Regulated Targeting of Proteins to Mitochondria During Apoptosis
Biochem Soc Trans (2000) 28 (5): A127.
ANALYSIS OF COMPONENTS OF SIGNALLING COMPLEXES
ALZHEIMER'S DISEASE
Amyloid and tau mice: phenotype and phenotype modulation
K. Duff; B. Malester; Y. Matsuoka; M. Picciano; J. Helpern; M. Merken; J. Lewis; M. Hutton; L. Refolo
Biochem Soc Trans (2000) 28 (5): A128.
Molecular Mechanisms of Familial Alzheimer's Disease
Sangram S. Sisodia; Seong Kim Jayme Martys; Rong Wang; Jeffrey Sklar; Bridget Berechid; Jeff Nye; Gopal Thinakaran
Biochem Soc Trans (2000) 28 (5): A129.
CELL GROWTH AND DEATH: CONTROL
ENZYME CATALYSIS: PATHWAY MECHANISMS
The molecular architecture of the shikimate pathway enzymes: new insights into mechanisms and drug design
Biochem Soc Trans (2000) 28 (5): A130.
GENOMICS IN AGRICULTURE AND MEDICINE
INTRACELLULAR AND EXTRACELLULAR ASPECTS OF LIPID SIGNALLING
Signalling via PI3Ks
K. Anderson; J. Coadwell; A. Condliffe; K. Davidson; C. Ellson; P. T. Hawkins; V. Paranavitane; S. Ridley; N. Risso; L. Stephens; S. Suire; H. Welch
Biochem Soc Trans (2000) 28 (5): A132.
NEW TECHNOLOGIES: STRUCTURE TO FUNCTION
THE STRUCTURE AND FUNCTION OF LECTINS
Problem-based learning
Changing a discipline-based medical course to a problem based course: gains and losses for biochemistry
Biochem Soc Trans (2000) 28 (5): A134.
Using PBL techniques to teach Biochemistry to medical students in a revised traditional curriculum
Biochem Soc Trans (2000) 28 (5): A134.
CELL GROWTH AND DEATH: CELL CYCLE EVENTS
CHANNELS
2P-DOMAIN K+ CHANNELS: STRUCTURE, PHYSIOLOGICAL FUNCTIONS, PHARMACOLOGY AND THERAPEUTIC IMPLICATIONS
F. Lesage; A.J. Patel; F. Maingret; I. Lauritzen; N. Blondeau; R. Reyes; C. Heurteaux; G. Romey; E. Honore; M. LAZDUNSKI
Biochem Soc Trans (2000) 28 (5): A135.
Redox Modulation of Calcium Release Channels (Ryanodine Receptors) From Excitable Cells
Biochem Soc Trans (2000) 28 (5): A136.
PROTEIN FOLDING PATHWAYS, INTERMEDIATES AND DISEASE
New Mechanisms of Inheritance Based on Self-perpetuating Changes in Protein Conformation
Biochem Soc Trans (2000) 28 (5): A137.
SIGNALLING IN PHYSIOLOGY AND DISEASE
SPECIFICATION AND PATTERNING OF THE NERVOUS SYSTEM
CELL GROWTH AND DEATH: APOPTOSIS
CHAPERONES AND PROTEIN FOLDING IN THE CELL
GENETIC ANALYSIS OF EMBRYONIC DEVELOPMENT
MOLECULAR BASIS OF TOXIC RESPONSE
PROTEIN KINASE-BASED SIGNALLING CASCADES
TRANSPORTERS
Structure and function of human ABC transporters involved in multidrug resistance of cancer
Biochem Soc Trans (2000) 28 (5): A143.
A common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter
Biochem Soc Trans (2000) 28 (5): A143.
The Lactose Permease of Escherichia coli: The Kamikaze Approach to Membrane Protein Structure and Function
Biochem Soc Trans (2000) 28 (5): A143.
BIOCHEMICAL EDUCATION
STRUCTURAL ORGANIZATION OF THE MOLECULE α-ACTININ
S. Q. Simonishvili; L. U. Rusia; K. Sh. Kuridze; M. Sh. Simonidze; R. M. Kupatadze; N. I. Svanidze; M. M. Zaalishvili
Biochem Soc Trans (2000) 28 (5): A145.
Demonstration of the comparative functions of the pentose phosphate pathway in the wine yeasts, Saccharomyces cerevisiae and Klockera apiculata
Biochem Soc Trans (2000) 28 (5): A145.
A new interactive-multimedia teaching approach for crowded class in the first year of medicine
Biochem Soc Trans (2000) 28 (5): A145.
BIOINFORMATICS
A fast measure of significance of Smith-Waterman alignment for sequence comparison
Biochem Soc Trans (2000) 28 (5): A146.
DESIGN AND SIMULATION OF A SHORT PEPTIDE WHOSE HELIX CONTENT CAN BE PHOTO-REGULATED BY MEANS OF AN AZOBENZENE-BASED CROSS-LINKER
Biochem Soc Trans (2000) 28 (5): A146.
Continuum Solvent Model Calculations of Alamethicin-Membrane Interactions: Thermodynamic Aspects
Biochem Soc Trans (2000) 28 (5): A147.
Classification of fusion-promoting peptides by use of DWIH and hydrophobic moment analysis
Biochem Soc Trans (2000) 28 (5): A148.
Analysis of oligonucleotides usage in known genomes: implications for prediction of regulatory sequences
Biochem Soc Trans (2000) 28 (5): A149.
BIOTECHNOLOGY
Molecular approaches for expression and identification analyses of truffle
Biochem Soc Trans (2000) 28 (5): A150.
Microbial Synthesis of High-Molecular-Weight Medium-Chain-Length Polyhydroxyalkanoates from lipids by Pseudomonas corrugata
Biochem Soc Trans (2000) 28 (5): A151.
Study of SYPRO Fluorescent Staining on Two Dimensional Gel Electrophoresis
Biochem Soc Trans (2000) 28 (5): A151.
Expression of a cryptic haloacid dehalogenase Chd1 from Burkholderia cepacia MBA4 in E. coli
Biochem Soc Trans (2000) 28 (5): A151.
MALDI- and Q-TOF Mass Spectrometry Analysis of Proteins Separated by Two-dimensional Gel Electrophoresis and Stained with A Modified Silver Stain Kit
Biochem Soc Trans (2000) 28 (5): A152.
IN VITRO STUDIES ON THE EFFECT OF SALINITY STRESS ON SOME MOLECULAR PROPERTIES OF YAM (Dioscorea alata) PLANTLETS
Biochem Soc Trans (2000) 28 (5): A152.
Heterologous expression of a haloalkane dehalogenase gene dhaA from Rhodococcus erythropolis Y2 in Escherichia coli
Biochem Soc Trans (2000) 28 (5): A153.
DISEASES: GENERAL
Soluble Intercellular Adhesion Molecule-1 and Soluble L-selectin Levels in Children With Bronchial Asthma
Biochem Soc Trans (2000) 28 (5): A153.
POLYMORPHISM IN THE HUMAN APOLIPOPROTELN B (APO B) GENE DIRECTLY TYPED BY THE POLYMERASE CHAIN REACTION
Biochem Soc Trans (2000) 28 (5): A153.
Reversal of Diabetic Complications by Vanadium & Plant derived antidiabetic Compunds
Biochem Soc Trans (2000) 28 (5): A154.
Cytosine methylation confers genetic instability on the cardiac troponin T gene in Hypertrophic Cardiomyopathy
L. G. D'cruz; H. E. Phillimore; P. M. Elliott; F. D. Davison; W. J. McKenna; N. D. Carter; C. Baboonian
Biochem Soc Trans (2000) 28 (5): A154.
Age-Related Alteration of Myofibril Isoenzyme Creatine Kinase From Heart of Rats During Stress
Biochem Soc Trans (2000) 28 (5): A155.
Longitudinal study of the relationship between glycaemia, peripheral arterial disease and mortality in diabetic patients
Biochem Soc Trans (2000) 28 (5): A155.
American cutaneous leishmaniasis in São Paulo State, Brazil: Preliminary results incriminating horses as hosts of Leishmania (Viannia) braziliensis
J. E. Tolezano; H. H. Tanuguchi; J. A. R. Barbosa; M. C. Bisugo; M. F. L. Araujo; S. C. F. Barbosa; V. A. Stempliuk; L. H. Ferreira; C. Petronilha; L. M. Floeter-Winter; J. J. Shaw
Biochem Soc Trans (2000) 28 (5): A155.
Uncoupling protein 2 expression in hypothalamus of rodents during fever and in different metabolic conditions
Biochem Soc Trans (2000) 28 (5): A156.
Effect of Extracts from Yam (Dioscorea cayenensis) and Dasheen (Colocassia esculenta) on the Kidney of Streptozotocin-induced Diabetic Rats
Biochem Soc Trans (2000) 28 (5): A156.
REGULATION AND IMMUNOHISTOCHEMICAL ANALYSIS OF HEME OXYGENASE-1 IN RAT KIDNEY WITH MYOGLOBINURIC ACUTE RENAL FAILURE
Biochem Soc Trans (2000) 28 (5): A156.
Effect of Khat Ingestion on some Glucogenic Hormones and Related Biochemical Activities in Diabetic Yemen Patients
Biochem Soc Trans (2000) 28 (5): A156.
The Effect of Vitamin B12 on the Cultivation of T vaginalis in Diamond Medium
Biochem Soc Trans (2000) 28 (5): A157.
The Association between the DNA Sequence Variations of Lipoprotein Lipase Gene and Korean Essential Hypertensives
Biochem Soc Trans (2000) 28 (5): A157.
Detection of anti-dsDNA IgG in DLE patients by an electrophoretic mobility shift assay and by ELISA
Biochem Soc Trans (2000) 28 (5): A158.
Two DNA Polymorphisms of Apolipoprotein(a) Gene in Korean Essential Hypertensives
Biochem Soc Trans (2000) 28 (5): A158.
Amino Acids and Their Metabolites in Blood Serum and Urine in Minimal Cerebral Dysfunction and Epilepsy
Biochem Soc Trans (2000) 28 (5): A158.
Alteration in the indices of connective tissue metabolism under gullet chemical burn
Biochem Soc Trans (2000) 28 (5): A159.
LEVEL OF FREE RADICAL PRODUCTS AND NADISOCITRATE DEHYDROGENASE ACTIVITY IN BLOOD OF PATIENTS WITH MYOCARDIUM INSUFFICIENCY
Biochem Soc Trans (2000) 28 (5): A159.
VITAMIN A CONSUMPTION DOES NOT AFFECT RMR AND FASTING RQ IN SEVERELY OBESE SUBJECTS
Biochem Soc Trans (2000) 28 (5): A159.
The hereditary hemochromatosis protein down-regulates apical iron uptake by Caco-2 cells
Biochem Soc Trans (2000) 28 (5): A160.
Properties of five rare human mutations causing medium chain acyl-CoA dehydrogenase deficiency
Biochem Soc Trans (2000) 28 (5): A160.
Importance of Catalse Enzyme in Virulence of Isoniazid Resistant Strains of Mycobacterium Tuberculosis in Guinea-Pigs
Biochem Soc Trans (2000) 28 (5): A160.
ERYTHROCYTE GLUCOSE UPTAKE INCREASE IN PATIENTS WITH DIABETES MELLITUS
Z. M. Shamansurova; Y. K. H. Turakulov; Z. S. Akbarov; N. F. Normukhamedova; M. Akhmedova; A. A. Kim
Biochem Soc Trans (2000) 28 (5): A161.
SCREENING METHODS IN INSULINORESISTANCE -THE “BRIDGE” BETWEEN ABDOMINAL OBESITY AND TYPE 2 DIABETES
Biochem Soc Trans (2000) 28 (5): A161.
Stat3/p65 heterodimer: Potential role in regulation of MMP-1 inhibitor gene in gingival fibroblasts
Biochem Soc Trans (2000) 28 (5): A162.
ASSOCIATION BETWEEN VITAMIN D RECEPTOR Bsm I POLYMORPHISM AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
Biochem Soc Trans (2000) 28 (5): A162.
MOLECULAR BASIS OF INHERITED DISORDERS OF ISOPRENOID BIOSYNTHESIS
H. R. Waterham; S. M. Houten; G. J. Romeijn; J. Koster; W. Oostheim; J. Frenkel; W. Kuis; B. T. Poll-The; R. J. A. Wanders
Biochem Soc Trans (2000) 28 (5): A163.
GENERATION AND SELECTION OF THE IMMUNOLOGLOBULIN REPERTOIRE OF ANTI-HUMAN GASTRIC CANCER SINGLE CHAIN Fv ANTIBODY BY THE PHAGE DISPLAY LIBRARY
Biochem Soc Trans (2000) 28 (5): A163.
DNA DAMAGE/REPAIR
In vivo protein interaction between Escherichia coli β sliding clamp and other proteins
Biochem Soc Trans (2000) 28 (5): A163.
Analysis of 6-furfuryl-adenine (kinetin) effects on template properties of DNA
Biochem Soc Trans (2000) 28 (5): A163.
Rapid screening of single nucleotide mutations and clastogenic damage by real time PCR and endonuclease and glycosylase dependent mechanisms
Biochem Soc Trans (2000) 28 (5): A164.
Non-specific Interaction of Fpg Protein from Escherichia coli with DNA. Affinity and Dynamics Study
Biochem Soc Trans (2000) 28 (5): A164.
The role of the τ subunit in the fidelity of replication of leading and lagging DNA strands in the Escherichia coli
Biochem Soc Trans (2000) 28 (5): A164.
Excision of 8-oxoguanine and hypoxanthine from DNA in hepatocytes of Wistar rats and rats with overgeneration of free radicals
Biochem Soc Trans (2000) 28 (5): A165.
Overproduction of Din7p in Saccharomyces cerevisiae results in the destabilisation of the mitochondrial DNA
Biochem Soc Trans (2000) 28 (5): A165.
DNA sequence analysis of λsusO8 revertants induced by MMS under nonpermissive conditions for phage DNA replication
Biochem Soc Trans (2000) 28 (5): A165.
Role of iron ions in the SOS DNA repair response induced in E.coli by nitric oxide donors
Biochem Soc Trans (2000) 28 (5): A165.
Influence of the nucleotide excision repair on growth properties of E. coli harbouring triplet repeats containing plasmids
Biochem Soc Trans (2000) 28 (5): A166.
The SOS mutator activity: unequal mutagenesis on leading and lagging strands
Biochem Soc Trans (2000) 28 (5): A166.
Genetic controls of DNA recombination during trypanosome antigenic variation
Biochem Soc Trans (2000) 28 (5): A166.