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February 1997
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
659th Meeting
Biochemical immunology group
Bioenergetics group
Importance of Haem Biosynthesis in the Control of Intestinal Iron Absorption
Biochem Soc Trans (1997) 25 (1): 58S.
Cell-surface molecular architecture
The binding of interleukin 2 to heparin revealed by a novel ELISA method
Biochem Soc Trans (1997) 25 (1): 3S.
Inhibition of erythrocyte aggregation by the silicates is reversed by masking the erythrocyte sulphydryl groups
Biochem Soc Trans (1997) 25 (1): 4S.
Radiolabelling characteristics of a paediatric mucosal organ culture model under varying preconditions
Biochem Soc Trans (1997) 25 (1): 6S.
Biochemical analysis of colonic mucin glycoproteins in children with Hirschsprung disease show disease specific alterations
Biochem Soc Trans (1997) 25 (1): 8S.
Location of endoplasmic reticulum relative to sarcoplasmic reticulum in cultured chick myotubes
Biochem Soc Trans (1997) 25 (1): 9S.
The yeast cell wall, a dynamic structure engaged in growth and morphogenesis
Biochem Soc Trans (1997) 25 (1): 200–204.
Glycoconjugate cross-talk in metastatic cancer cells, leucocytes, parasites and bacteria
Biochem Soc Trans (1997) 25 (1): 228–234.
Glycobiology Group
The core glycosylphosphatidylinositol anchor structures of Trypanosoma brucei variant surface glycoprotein 221
Biochem Soc Trans (1997) 25 (1): 13S.
Hexokinase/glucokinase
Purification and identification of an epoxide hydrolase from equine liver
Biochem Soc Trans (1997) 25 (1): 66S.
Structural determinants that make hexokinase susceptible to ubiquitin-and ATP- dependent proteolysis
Biochem Soc Trans (1997) 25 (1): 69S.
INS-1 cells as a model for studying the role of pancreatic glucose-6-phosphatase in glucokinase dependent glucose-mediated insulin secretion
Biochem Soc Trans (1997) 25 (1): 71S.
Interaction of Sp1 and NF-Y in the diet-induced regulation of the rat fatty acid synthase (FAS) gene
Biochem Soc Trans (1997) 25 (1): 72S.
Hexokinases
Effects of altered glucokinase gene copy number on blood glucose homoeostasis
Biochem Soc Trans (1997) 25 (1): 113–117.
Molecular genetics of the human glucokinase regulator-fructokinase (GCKR-KHK) region of chromosome 2p23
B. E. Hayward; J. P. Warner; N. Dunlop; J. Fantes; S. Intody; J. Leek; A. F. Markham; D. T. Bonthron
Biochem Soc Trans (1997) 25 (1): 140–145.
Bridging the gap between glucose phosphorylation and glycogen synthesis in the liver
Biochem Soc Trans (1997) 25 (1): 157–160.
Hormone group
Degradation of pyroglutamyl-phenylalanyl-proline amide by a pyroglutamyl aminopeptidase purified from membrane fractions of bovine brain
Biochem Soc Trans (1997) 25 (1): 114S.
ENDOTHELIN-1 ACTS THROUGH ETA RECEPTORS TO STIMULATE ALDOSTERONE SECRETION BY THE RAT ADRENAL GLAND
Biochem Soc Trans (1997) 25 (1): 116S.
Gö 6976: An inhibitor of Ca2+/DAG-dependent protein kinase C isoforms in islets of Langerhans
Biochem Soc Trans (1997) 25 (1): 118S.
Industrial biochemistry and biotechnology group
Thermostable cytochrome P450 steroid hydroxylase from a thermophilic bacillus strain
Biochem Soc Trans (1997) 25 (1): 17S.
Purification and characterisation of progesterone hydroxylase, cytochrome P-450 from Streptomyces roseochromogenes ATCC 13400
Biochem Soc Trans (1997) 25 (1): 18S.
Species specific polymerase chain reaction to detect Cryptosporidium parvum and C. muris.
Biochem Soc Trans (1997) 25 (1): 19S.
Lipid group
Evidence for overt and latent forms of DGAT in rat liver microsomes Implications for the pathways of triacylglycerol incorporation into VLDL
Biochem Soc Trans (1997) 25 (1): 21S.
Phospholipid headgroup mobility in low density lipoproteins
Helena C. MURPHY; Alia RAOOF; John J. WHITE; Mika ALAKORPELA; Jimmy D. BELL; Maria L. BARNARD; Richard A. ILES
Biochem Soc Trans (1997) 25 (1): 22S.
Differential effects of different dietary fats on enzymes regulating cholesterol storage in rat liver
Biochem Soc Trans (1997) 25 (1): 24S.
The effect of cyclic AMP analogues on cholesteryl ester synthesis and hydrolysis in cultured rat peritoneal macrophages
Biochem Soc Trans (1997) 25 (1): 25S.
Lipid mimetics: the design and properties of conformationally-restricted arachidonic acid lipidic and peptidic analogues
Biochem Soc Trans (1997) 25 (1): 26S.
Microbial lipases: structure, function and industrial applications
Purification and characterisation of a novel extracellular lipase from Xanthomonas maltophila
Biochem Soc Trans (1997) 25 (1): 14S.
Transformations of steroid sulphates by human axillary bacteria. A mechanism for human odour formation?
Biochem Soc Trans (1997) 25 (1): 16S.
Microbial Lipases: Structures, Function and Industrial Applications
Chiral preference of cutinase in the reaction with phosphonate inhibitors
Biochem Soc Trans (1997) 25 (1): 165–170.
Bacillus thermocatenulatus lipase: a thermoalkalophilic lipase with interesting properties
Biochem Soc Trans (1997) 25 (1): 178–182.
Modern electrophoresis techniques in biochemistry
Analysis of the N-(deoxyguanosin-8-yl) adduct of the food derived carcinogen PhIP using capillary electrophoresis
Biochem Soc Trans (1997) 25 (1): 27S.
Histochemical staining of ducts in submandibular glands by DMAB-nitrite detects stored tissue kallikreins
Biochem Soc Trans (1997) 25 (1): 28S.
Rapid identification of proteinases and their inhibitors by Enzyme Overlay Membrane techniques
Biochem Soc Trans (1997) 25 (1): 30S.
Expression of proline-rich proteins in the parotid & submandibular glands of the untreated rat
Biochem Soc Trans (1997) 25 (1): 31S.
Improved staining of human salivary proteins following electrophoresis
Biochem Soc Trans (1997) 25 (1): 32S.
Reduced synthesis of proline-rich proteins in denervated rat parotid glands
Biochem Soc Trans (1997) 25 (1): 33S.
Lipid profiling in renal and hepatic tissue slices following exposure to atractyloside
Biochem Soc Trans (1997) 25 (1): 35S.
Modern Electrophoretic Techniques in Biochemistry
Identification of low to subpicomolar quantities of electrophoretically separated proteins: towards protein chemistry in the post-genome era
Biochem Soc Trans (1997) 25 (1): 255–262.
Identification of amplifications, deletions and methylation changes in cancer by means of two-dimensional analysis of genomic digests: application to neuroblastoma
Biochem Soc Trans (1997) 25 (1): 262–267.
Molecular action of oestrogens in the prevention of cardiovascular disease
Effects of hormones on the plasma levels of the atherogenic amino acid homocysteine
Biochem Soc Trans (1997) 25 (1): 33–35.
Inhibition of protein tyrosine phosphorylation in endothelial cells: relationship to antiproliferative action of genistein
Biochem Soc Trans (1997) 25 (1): 35–40.
Prospects for the production and use of new improved dietary oestrogens for cardioprotection
Biochem Soc Trans (1997) 25 (1): 59–63.
Antioxidant action of novel derivatives of the apple-derived flavonoid phloridzin compared to oestrogen: relevance to potential cardioprotective action
Biochem Soc Trans (1997) 25 (1): 106S.
The cardioprotective antioxidant activity of dietary phytoestrogens compared to oestrogen
Biochem Soc Trans (1997) 25 (1): 107S.
Influence of the dietary flavonoid quercetin on the cardioprotective antioxidant action of oestrogen and phytoestrogens
Biochem Soc Trans (1997) 25 (1): 108S.
Protein kinase inhibition and the oestrogen - like relaxant effects of genistein on isolated rat aorta
Biochem Soc Trans (1997) 25 (1): 111S.
Differential effects of steroids on vascular tone and smooth muscle cell Ca2+-homeostasis
Biochem Soc Trans (1997) 25 (1): 112S.
Molecular and cellular pharmacology group
Cytokines increase B1 bradykinin receptor mRNA and protein levels in human lung fibroblasts
Biochem Soc Trans (1997) 25 (1): 43S.
Time-dependent translocation of the α and β1 isotypes of protein kinase C in human platelets in response to phorbol ester stimulation
Biochem Soc Trans (1997) 25 (1): 44S.
The activation of the alpha isotype of protein kinase C by phorbol ester in Swiss 3T3 cells
Biochem Soc Trans (1997) 25 (1): 45S.
The effects of phenylisocyanate on rat liver mitochondria using the oxygen electrode technique
Biochem Soc Trans (1997) 25 (1): 46S.
Isocyanate binding to yeast glutathione reductase measured by fluorescence spectroscopy
Biochem Soc Trans (1997) 25 (1): 47S.
Molecular enzymology group
The effects of bile salts on the kinetic properties of enzymes used in the diagnosis of liver and kidney damage
Biochem Soc Trans (1997) 25 (1): 76S.
CbiX: A novel metal-binding protein involved in sirohaem biosynthesis in Bacillus megaterium
Biochem Soc Trans (1997) 25 (1): 77S.
Structural studies on 5-aminolaevulinic acid dehydratase from Saccharomyces cerevisiae (yeast)
Biochem Soc Trans (1997) 25 (1): 78S.
Discovery of a novel mechanism for cofactor assembly by Escherichia coli porphobilinogen deaminase
Biochem Soc Trans (1997) 25 (1): 79S.
Characterisation and expression of a chicken erythroblast mono(ADP-ribosyl)transferase gene
Biochem Soc Trans (1997) 25 (1): 80S.
Interaction of (ADP-ribose)polymerase with synthetic oligodeoxynucleotide duplexes
Biochem Soc Trans (1997) 25 (1): 81S.
Cell-free activity of magnesium chelatase in Rhodobacter spheroides and Rhodobacter capsulatus
Biochem Soc Trans (1997) 25 (1): 82S.
Designing immunogens for the generation of antibodies that catalyse the hydrolysis of cocaine
Biochem Soc Trans (1997) 25 (1): 83S.
Effects of site-specific mutations on the kinetically influential ionizations of papain
Biochem Soc Trans (1997) 25 (1): 84S.
Are polyclonal catalytic antibodies heterogeneous?
STEVEN CARTER; MARINA RESMINI; CAROLINE SIMMS; SUNEAL K. SREEDHARAN; GERARD GALLACHER; KEITH BROCKLEHURST
Biochem Soc Trans (1997) 25 (1): 86S.
Effects of the quality of the P2-S2 hydrophobic contacts on the catalytic activities of papain, caricain and ficin and their generation by electrostatic switches
SURAPONG PINITGLANG; MANIJ PATEL; MICHAEL NOBLE; SUNEAL K. SREEDHARAN; CHANDRA VERMA; EMRYS W. THOMAS; KEITH BROCKLEHURST
Biochem Soc Trans (1997) 25 (1): 88S.
Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probes
SHERAZ GUL; ANNA CLARKE; BEN FIELD; MARK P. THOMAS; FRANCES WILLENBROCK; SURAPONG PINITGLANG; CHANDRA VERMA; EMRYS W. THOMAS; KEITH BROCKLEHURST
Biochem Soc Trans (1997) 25 (1): 91S.
Design and synthesis of substrate-derived n-acylaminoalkyl 2-pyridyl disulphides as probes of cysteine proteinase mechanism
Biochem Soc Trans (1997) 25 (1): 92S.
Evidence that the active site in type II dehydroquinase from Streptomyces coelicolor is near the single tryptophan
Biochem Soc Trans (1997) 25 (1): 93S.
Neurochemical group
5-HT1B/D antagonists potentiate paroxetine's effect on 5-HT efflux in the lateral geniculate nucleus: in vitro voltammetric data
Biochem Soc Trans (1997) 25 (1): 49S.
New insights into the molecular and cellular regulation of glycogen storage and degradation
Enhancement of glucose uptake and utilization in cultured human muscle fibres overexpressing muscle glycogen phosphorylase
Biochem Soc Trans (1997) 25 (1): 7–10.
Glycogen synthase: activation by insulin and effect of transgenic overexpression in skeletal muscle
Biochem Soc Trans (1997) 25 (1): 14–19.
Replenishment of muscle glycogen after high-intensity exercise: a role for intramuscular lactate glyconeogenesis?
Biochem Soc Trans (1997) 25 (1): 25–30.
Activation of glycogen synthase in skeletal muscle: effects of insulin during late pregnancy
Biochem Soc Trans (1997) 25 (1): 100S.
Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
Biochem Soc Trans (1997) 25 (1): 101S.
Activation of glycogen synthase in skeletal muscle: effects of insulin in slow- and fast-twitch muscles in vivo
Biochem Soc Trans (1997) 25 (1): 102S.
Modulation of hepatic pyruvate dehydrogenase kinase (PDHK) activity by insulin and dietary composition
Biochem Soc Trans (1997) 25 (1): 103S.
The inositol 1,4,5-trisphosphate 6-kinase of Schizosaccharomyces pombe
Biochem Soc Trans (1997) 25 (1): 105S.
Non-haem iron and oxygen
Model complexes of di-iron sites in methane mono-oxygenase and ribonucleotide reductase: structure and reactivity
Biochem Soc Trans (1997) 25 (1): 65–69.
Ribonucleotide reductase, lipoxygenase and the intracellular low-molecular-weight iron pool
Biochem Soc Trans (1997) 25 (1): 75–80.
Studies on non-haem ferrous-dependent oxygenases and oxidases
J. N. Barlow; J. E. Baldwin; I. J. Clifton; E. Gibson; C. M. H. Hensgens; J. Hajdu; T. Hara; A. Hassan; P. John; M. D. Lloyd; P. L. Roach; A. Prescott; J. K. Robinson; Z.-H. Zhang; C. J. Schofield
Biochem Soc Trans (1997) 25 (1): 86–90.
Structural studies on the catalytic component of benzene dioxygenase from Pseudomonas putida
Biochem Soc Trans (1997) 25 (1): 90–95.
Pumping iron: does bacterioferritin contain a redox-driven iron pump?
Biochem Soc Trans (1997) 25 (1): 96–101.
Kinetic interaction between oxidases and dehydrogenases in plant mitochondria
Biochem Soc Trans (1997) 25 (1): 60S.
Biochemical Responses of the Marine Macroalgae Ulva lactuca and Fucus vesiculosus to Cadmium and Copper - from Sequestration to Oxidative Stress
Biochem Soc Trans (1997) 25 (1): 63S.
Catalytic mechanism of the novel non-haem iron containing peroxidase produced by the thermophilic actinomycete Thermomonospora fusca BD25
Biochem Soc Trans (1997) 25 (1): 64S.
Optimisation of production of extracellular nonhaem peroxidases by Thermomonospora fusca BD25 in aerobic bio-reactor conditions
Biochem Soc Trans (1997) 25 (1): 65S.
Nucleic acids and molecular biology group
Monoclonal antibodies from three new regions of huntingtin, the Huntington's disease protein
Biochem Soc Trans (1997) 25 (1): 51S.
Isolation and characterisation of human genomic sequences encoding cytosolic serine hydroxymethyltransferase
Biochem Soc Trans (1997) 25 (1): 53S.
Nucleotide sequences from the capsid and pre-protein regions of dengue viruses from VietNam
Biochem Soc Trans (1997) 25 (1): 54S.
Protein and peptide science group
NMR-Based Modelling Revealed an Alpha Helical Structure for Cytoplasmic Domain of the Alpha Subunit of FcεRI, the High Affinity IgE Receptor
Biochem Soc Trans (1997) 25 (1): 55S.
The role and importance of different fragments of NAD+ in refolding of Clostridium symbiosum glutamate dehydrogenase
Biochem Soc Trans (1997) 25 (1): 56S.
Regulation in metabolism group
Cytokine-induced activation of xanthine oxidase in human mammary epithelial cells
SUSANNA PAGE; MUSTAPHA BENBOUBETRA; DAVID BLAKE; DEBBIE POWELL; FISHAYE SELASE; CLIFF STEVENS; ADRIAN WOLSTENHOLME; ROGER HARRISON
Biochem Soc Trans (1997) 25 (1): 95S.
Choline and L-carnitine as precursors of trimethylamine
Heather C. HOLMES; Shamus P. BURNS; Helen MICHELAKAKIS; V. KORDONI; Murray D. BAIN; Ronald A. CHALMERS; Joan E. M. RAFTER; Richard A. ILES
Biochem Soc Trans (1997) 25 (1): 96S.
Effects of dexamethasone and interleukin-6 on urea production by human hepatocytes in vitro
Biochem Soc Trans (1997) 25 (1): 97S.
Salt sensitivity and arginase activity in Aspergillus nidulans
NICOLA A. ATTWELL; DARREN J. CLEMENT; MICHELE S. STANLEY; NICHOLAS J. W. CLIPSON; PAUL HOOLEY; DARON A. FINCHAM
Biochem Soc Trans (1997) 25 (1): 98S.
Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta
Biochem Soc Trans (1997) 25 (1): 99S.
Techniques group
Equilibrium and pre-equilibrium fluorescence studies on the interaction between Protein L and kappa light chain
Biochem Soc Trans (1997) 25 (1): 38S.
Bovine inositol monophosphatase: Metal-binding interactions at two different sites
Biochem Soc Trans (1997) 25 (1): 39S.
Nitrite Reductase from Achromobacter xylosoxidans forms stable trimers in dilute solution
Biochem Soc Trans (1997) 25 (1): 40S.
Who needs lectures? What are the alternatives? Is problem-based learning the answer?
Who Needs Lectures? What are the Alternatives?
Correction
Irish Area Section Meeting
DNA Damage and Mutagenesis
Mammalian nucleotide excision repair and syndromes
W. Vermeulen; J. de Boer; E. Citterio; A. J. van Gool; G. T. J. van der Horst; N. G. J. Jaspers; W. L. de Laat; A. M. Sijbers; P. J. van der Spek; K. Sugasawa; G. Weeda; G. S. Winkler; D. Bootsma; J.-M. Egly; J. H. J. Hoeijmakers
Biochem Soc Trans (1997) 25 (1): 309–315.
Detection of p53 mutations in oral cancer samples using a sensitive PCR-based method
Biochem Soc Trans (1997) 25 (1): 315–318.
DNA repair in thermophiles: investigation of DNA-binding activities in Thermus aquaticus
Biochem Soc Trans (1997) 25 (1): 319–322.
Oxidative DNA damage in human cells: the influence of antioxidants and DNA repair
Biochem Soc Trans (1997) 25 (1): 326–331.
Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line
Biochem Soc Trans (1997) 25 (1): 335–342.
p53 mutations in squamous cell carcinomas from renal transplant recipients
Biochem Soc Trans (1997) 25 (1): 342–345.
Irish Area Section Meeting
Irish Area Section Meeting, University of Ulster, Coleraine
The possible role of aminopeptidases from starter culture Lactococcus lactis subspecies cremoris AM2 in cheese making
Biochem Soc Trans (1997) 25 (1): 119S.
Factors in post dialysis CAPD fluid affecting 3H cholesterol efflux from human skin fibroblasts
Biochem Soc Trans (1997) 25 (1): 123S.
Local cellular immunity to the respiratory pathogen Bordetella pertussis: role of costimulatory molecules
Biochem Soc Trans (1997) 25 (1): 124S.
STUDIES INTO THE MECHANISM OF NFκB ACTIVATION BY IL1, TNF AND H2O2 IN PRIMARY AND TRANSFORMED ENDOTHELIAL CELLS
Biochem Soc Trans (1997) 25 (1): 125S.
The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells
Biochem Soc Trans (1997) 25 (1): 126S.
Sequence analysis of spontaneously-arising mutations at the aprt locus in wild-type and thymidine kinase-deficient Friend cells: Evidence for strand slippage-misalignment mechanism in formation of deletions
PAULA L. HYLAND; MARK W. MCKINNEY; ANNE L. KEEGAN; PATRICK. G. MCKENNA; MARTIN. D. CURRAN; DEREK MIDDLETON; YVONNE. A. BARNETT
Biochem Soc Trans (1997) 25 (1): 127S.
Glycation of insulin in a cultured insulin-secreting cell line
Biochem Soc Trans (1997) 25 (1): 128S.
Identification of the inducible nitric oxide synthase gene in macro-and microvascular endothelial cell lines
Biochem Soc Trans (1997) 25 (1): 129S.
ISLET ANTIOXIDANT AND SECOND PHASE ENZYME LEVELS FOLLOWING CYP1A, CYP2E, CYP2B AND CYP4A INDUCTION
Biochem Soc Trans (1997) 25 (1): 133S.
Lipoprotein lipase in human monocyte-derived macrophages isolated from type II diabetic subjects
Biochem Soc Trans (1997) 25 (1): 134S.
DNA damage induced in T50/80 tumour cells following exposure to the bioreductive drug Tirapazamine in combination with a single dose of radiation (12Gy)
Biochem Soc Trans (1997) 25 (1): 135S.
An investigation of the radioprotective effect of dietary antioxidants on isolated murine lymphocytes
Biochem Soc Trans (1997) 25 (1): 136S.
Visible light inhibits proliferation of the human monoblastic U937 cell line
Biochem Soc Trans (1997) 25 (1): 138S.
Some effects of 1,4-dihydroisonicotinic acid derivatives on repair pathways involved in chemical mutagenesis
Biochem Soc Trans (1997) 25 (1): 139S.
Lack of relationship between TNF-α-stimulated endothelin-1 production and loss of barrier function in endothelial cells
Biochem Soc Trans (1997) 25 (1): 141S.
Mechanisms of action of cationic amino acids on insulin-secreting BRIN-BD11 cells
Biochem Soc Trans (1997) 25 (1): 144S.
The effects of α-tocopherol addition on oxidative stability of whole milk powder
Biochem Soc Trans (1997) 25 (1): 145S.
Antioxidant status, oxidative stress and DNA damage in the aetiology of Malnutrition Related Diabetes Mellitus
MARGARET MCDONAGH; LIAQUAT ALI; AZAD KAHN; PETER R. FLATT; YVONNE A. BARNETT; CHRISTOPHER R. BARNETT
Biochem Soc Trans (1997) 25 (1): 146S.
Matrix metalloproteinase and tissue inhibitor of metalloproteinase regulation of the invasive potential of a metastatic renal cell line
Biochem Soc Trans (1997) 25 (1): 147S.
An investigation of the role of adenine phosphoribosyltransferase for excision repair following UV irradiation in Friend cells
Biochem Soc Trans (1997) 25 (1): 149S.
Glycation of insulin by phosphorylated and non-phosphorylated reducing sugars
Biochem Soc Trans (1997) 25 (1): 150S.
Studies on double strand DNA damage, repair and mutagenesis in E.coli and the implications to Fanconi's anaemia
Biochem Soc Trans (1997) 25 (1): 151S.
