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October 1990
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ISSN 0300-5127
EISSN 1470-8752
In this Issue
634th Meeting
COMMUNICATION
Detection of Trypanosoma cruzi by simplified dot blot with a total genomic DNA probe
Biochem Soc Trans (1990) 18 (5): 859–860.
Inhibition of the bloodstream/procyclic transformation in Trypanosoma brucei
Biochem Soc Trans (1990) 18 (5): 860–861.
Nicotinamide uptake and metabolism in the procyclic form of Trypanosoma brucei
Biochem Soc Trans (1990) 18 (5): 861–862.
Identification of dihydrolipoamide dehydrogenase in the procyclic form of Trypanosoma brucei
I. DAVID COOK; SIMON A. JACKMAN; MICHAEL J. DANSON; ROBERT EISENTHAL; DAVID W. HOUGH; WILLIAM J. D. WHISH
Biochem Soc Trans (1990) 18 (5): 862–863.
Detection of an alkaline peptidase in Leishmania amastigotes and promastigotes
Biochem Soc Trans (1990) 18 (5): 864–865.
Detection of peptidase activities in Trypanosoma cruzi using chromogenic and fluorogenic substrates
Biochem Soc Trans (1990) 18 (5): 865–866.
Substrate specificity and inhibitor sensitivity of a Trypanosoma cruzi alkaline peptidase
Biochem Soc Trans (1990) 18 (5): 866–867.
Mapping of B-cell epitopes on the Leishmania donovani 70 kDa heat-shock protein
Biochem Soc Trans (1990) 18 (5): 867.
Pepscan and circular-dichroism analysis of a repetitive antigen of Trypanosoma cruzi
Biochem Soc Trans (1990) 18 (5): 868–869.
Role of the pentose phosphate pathway in the provision of precursors for nucleic acid biosynthesis in bloodstream Trypanosoma brucei
Biochem Soc Trans (1990) 18 (5): 870–871.
Reversibly electropermeabilized platelets: potential use as vehicles for drug delivery
Biochem Soc Trans (1990) 18 (5): 871–873.
Macrophage phagocytosis of platelet-encapsulated muramyl dipeptide: macrophage/tumour cell cytotoxicity studies
Biochem Soc Trans (1990) 18 (5): 874–875.
Modelling of drug absorption in rabbit intestinal brush border membrane vesicles
Biochem Soc Trans (1990) 18 (5): 875–876.
Effect of surface-bound lectin on the release of encapsulated sugar from vesicle delivery systems
Biochem Soc Trans (1990) 18 (5): 876–877.
Tamoxifen inhibits RNA and protein synthesis simultaneously in Saccharomyces cerevisiae: partial protection by antioxidants
Biochem Soc Trans (1990) 18 (5): 877–878.
Binding of tomato lectin to the intestinal mucosa and its potential for oral drug delivery
Biochem Soc Trans (1990) 18 (5): 879–880.
Targeting of a chelating derivative of a short-chain analogue of α-melanocyte stimulating hormone to Cloudman S91 melanomas
Biochem Soc Trans (1990) 18 (5): 882–883.
Molecular forms of angiotensin-converting enzyme in brain microvessels
Biochem Soc Trans (1990) 18 (5): 887.
Hydrolysis of natriuretic peptides by the human astrocytoma clone D384
MARGARET DOS SANTOS MEDEIROS; ANTHONY J. BALMFORTH; PETER F. T. VAUGHAN; A. JOHN KENNY; ANTHONY J. TURNER
Biochem Soc Trans (1990) 18 (5): 888–889.
Effects of anti-calcium channel α2-subunit antibodies on calcium flux and 1,4-dihydropyridine binding
Biochem Soc Trans (1990) 18 (5): 890.
Cloning and characterization of a cDNA encoding a human brain potassium channel
Biochem Soc Trans (1990) 18 (5): 891.
The β-cell ATP-sensitive K+-channel: effects of ADP at the sulphonylurea binding site
Biochem Soc Trans (1990) 18 (5): 891–892.
Measurement of matrix Mg2+ concentration of rat heart mitochondria using fluorescent probes
Biochem Soc Trans (1990) 18 (5): 894–895.
Metalloproteinases in the intestine of patients with Crohn's disease
CAROLINE J. BAILEY; ROSALIND M. HEMBRY; ANNE ALEXANDER; C. ADRIAN SHUTTLEWORTH; MICHAEL E. GRANT; MILES L. IRVING
Biochem Soc Trans (1990) 18 (5): 896–897.
Growth factors modulate collagen production and collagenase action by skin fibroblasts in a dermal equivalent model system
Biochem Soc Trans (1990) 18 (5): 899–900.
Hydrolysis of alanyl-containing tetrapeptides by Pseudomonas aeruginosa proteinases
Biochem Soc Trans (1990) 18 (5): 900–901.
Distribution of glycoprotease activity and the glycoprotease gene among serotypes of Pasteurella haemolytica
Biochem Soc Trans (1990) 18 (5): 901–903.
Fatty acid inhibition of lipopolysaccharide-stimulated B lymphocyte proliferation
Biochem Soc Trans (1990) 18 (5): 904–905.
A longitudinal study of plasma n — 3 fatty acid levels in a family with X-linked retinitis pigmentosa
TRACEY McLACHLAN; AVRIL J. McCOLL; MARY-F. COLLINS; CAROLYN A. CONVERSE; CHRISTOPHER J. PACKARD; JAMES SHEPHERD
Biochem Soc Trans (1990) 18 (5): 905–906.
Polyunsaturated fatty acid metabolism in miniature poodles with an inherited retinal degeneration
Biochem Soc Trans (1990) 18 (5): 906–907.
The fatty acid composition of phospholipids from the eyes of the northern deepwater prawn, Pandalus borealis
Biochem Soc Trans (1990) 18 (5): 907–908.
Comparative effects of n − 9, n − 6 and n − 3 dietary fatty acids on mammary tumour incidence and membrane phospholipid fatty acid compositions
Biochem Soc Trans (1990) 18 (5): 908–909.
Fasting and postprandial triacylglycerol responses to a standard test meal in subjects taking dietary supplements of n − 3 fatty acids
Biochem Soc Trans (1990) 18 (5): 909–910.
Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar)
Biochem Soc Trans (1990) 18 (5): 911–912.
Medium-chain acyl-CoA dehydrogenase deficiency: A 1H-n.m.r. spectroscopic study
Biochem Soc Trans (1990) 18 (5): 912–913.
Effects of n − 3 and n − 6 polyunsaturated fatty acids on the growth of fish cells in culture
Biochem Soc Trans (1990) 18 (5): 915–916.
Cross-linking, fragmentation and anomalous behaviour on SDS gels, of proteins glycated in vitro
Biochem Soc Trans (1990) 18 (5): 916–917.
Computer-generated diagrams for relating primary structure to three-dimensional features in proteins
Biochem Soc Trans (1990) 18 (5): 917–918.
Molecular modelling and design of analogues of the peptide hormone urotensin II
Biochem Soc Trans (1990) 18 (5): 918–919.
1H n.m.r. studies of serum albumin: assignment of resonances for N-terminal amino acids
Biochem Soc Trans (1990) 18 (5): 923–924.
Multiple isomorphous replacement: a genetic engineering approach to the generation of heavy atom derivatives
Biochem Soc Trans (1990) 18 (5): 925–926.
In vitro transcription/translation of the alginate lyase gene from Klebsiella pneumoniae and detection of a precursor form of the enzyme
Biochem Soc Trans (1990) 18 (5): 927–928.
Heterologous expression and cellular distribution in Escherichia coli of the gene from Klebsiella pneumoniae which encodes alginate lyase
Biochem Soc Trans (1990) 18 (5): 929–930.
High conservation of β2-microglobulin contact residues among 82 class I major histocompatability complex α-chain sequences
Biochem Soc Trans (1990) 18 (5): 930–931.
Structural analysis of galactose oxidase
NOBUTOSHI ITO; JEFFREY N. KEEN; PETER F. KNOWLES; MICHAEL J. McPHERSON; SIMON E. V. PHILLIPS; CONRAD STEVENS; KAPIL D. S. YADAV
Biochem Soc Trans (1990) 18 (5): 931–932.
Three-dimensional structure of a B-type chymopapain
CHRISTOPHER M. TOPHAM; JOHN OVERINGTON; MAIREAD O'DRISCOLL; ERDJAN SALIH; MARK THOMAS; EMRYS W. THOMAS; KEITH BROCKLEHURST
Biochem Soc Trans (1990) 18 (5): 933–934.
Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV)
CHRISTOPHER M. TOPHAM; JOHN OVERINGTON; MARK THOMAS; DEVANAND KOWLESSUR; EMRYS W. THOMAS; KEITH BROCKLEHURST
Biochem Soc Trans (1990) 18 (5): 934–935.
Measuring diffusion coefficients of labelled particles on cell surfaces by digital fluorescence microscopy
Biochem Soc Trans (1990) 18 (5): 938.
Membrane potential measurements of the effect of melittin on lipid vesicles, erythrocytes and resealed ghosts
Biochem Soc Trans (1990) 18 (5): 939.
Interaction of erythrocyte cytoskeletal proteins with band 3: rotational diffusion measurements
Biochem Soc Trans (1990) 18 (5): 940.
The osmotically-induced fusion of erythrocytes is associated with a change in phospholipid asymmetry
Biochem Soc Trans (1990) 18 (5): 941.
Lytic effects of melittin on vesicles of dipalmitoylphosphatidylcholine reconstituted with bacteriorhodopsin
Biochem Soc Trans (1990) 18 (5): 942.
Uptake of glutamine in Xenopus oocytes: inhibition by 6-diazo-5-oxo-l-norleucine and harmaline
Biochem Soc Trans (1990) 18 (5): 944–945.
Use of transmembrane pH gradients and A 23187 to produce dense iron liposomes
Biochem Soc Trans (1990) 18 (5): 946–947.
Ca2+-ATPase in sarcoplasmic reticulum from species adapted to warm and cold environments
Biochem Soc Trans (1990) 18 (5): 948.
Investigation into structural features of the Escherichia coli penicillin-binding protein 5 C-terminal anchor
Biochem Soc Trans (1990) 18 (5): 948–949.
Changes in phospholipid composition of bacterial membranes prevent formation of non-bilayer phases in vitro and in vivo by high solute concentrations
Biochem Soc Trans (1990) 18 (5): 950.
Effect of interleukin-1 and tumour necrosis factor-α on the turnover of proteoglycans in human articular cartilage
Biochem Soc Trans (1990) 18 (5): 953–954.
Responses of T-cells from patients with inflammatory arthritis to human cartilage antigens
Biochem Soc Trans (1990) 18 (5): 955.
Assay of mucus secreted from isolated stomach cells by using an enzyme-linked immunosorbent assay
Biochem Soc Trans (1990) 18 (5): 956.
Similar age-related alterations in collagen metabolism in rat tissues in vivo and fibroblasts in vitro
Biochem Soc Trans (1990) 18 (5): 957.
Comparison of heparan sulphate proteoglycans from bovine glomerular basement membranes with those from whole cortex
Biochem Soc Trans (1990) 18 (5): 959.
A comparison of proteoglycan arrangement in normal and keratoconus human corneas
Biochem Soc Trans (1990) 18 (5): 961–962.
Modulation of extracellular matrix proteins and the influence of fucoidan on cell proliferation of smooth muscle cells
Biochem Soc Trans (1990) 18 (5): 962–963.
Investigation of the metabolism of l-fucose in aortic tissue and cultured arterial wall cells
Biochem Soc Trans (1990) 18 (5): 963–964.
Serum keratan sulphate levels rise in rheumatoid arthritis patients, but fall in ankylosing spondylitis patients compared with normal controls
Biochem Soc Trans (1990) 18 (5): 964–965.
Heparin induces synthesis of highly charged heparan sulphate by vascular smooth muscle cells
Biochem Soc Trans (1990) 18 (5): 965.
Steady-state radiolabelling of proteoglycans in vivo: application to the measurement of proteoglycan turnover and synthesis
Biochem Soc Trans (1990) 18 (5): 967.
Cell-surface oligosaccharides expressed by phenotypically distinct sublines of the Dunning 3327 rat prostate cancer
Biochem Soc Trans (1990) 18 (5): 968–969.
Variability in the immunochemical quantification of keratan sulphate in human and bovine cartilage proteoglycans
Biochem Soc Trans (1990) 18 (5): 969–970.
Proteoglycan metabolism in chondrocytes of young pig articular cartilage and its modulation by therapeutic agents
Biochem Soc Trans (1990) 18 (5): 972.
Effects of catabolic and anabolic cytokines on proteoglycan biosynthesis in young, old and osteoarthritic canine cartilage
Biochem Soc Trans (1990) 18 (5): 973–974.
Inhomogeneity of skeletal muscle glycogen synthesis upon refeeding following starvation
Biochem Soc Trans (1990) 18 (5): 974–975.
Acute effects of epidermal growth factor on oxidative metabolism in livers from fed and starved rats
Biochem Soc Trans (1990) 18 (5): 977–978.
Effects of chronic ethanol feeding on muscle metabolism in the rat
Biochem Soc Trans (1990) 18 (5): 978–979.
Effect of synthetic human amylin on glycogen synthesis in skeletal muscle in vivo
Biochem Soc Trans (1990) 18 (5): 980.
Interleukin-1 stimulation of fibroblast glycolysis is accompanied by reduced glucose oxidation in the tricarboxylic acid cycle
Biochem Soc Trans (1990) 18 (5): 982–983.
Liver flux of branched-chain amino acids in vivo during the starved-fed transition in the rat
Biochem Soc Trans (1990) 18 (5): 983–984.
Skeletal muscle glucose disposal after re-feeding in the hyperthyroid rat
Biochem Soc Trans (1990) 18 (5): 986–987.
Changes in adipose tissue glucose metabolism associated with the fasting-refeeding cycle
Biochem Soc Trans (1990) 18 (5): 992.
Activity and expression of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the starved-to-fed transition
Biochem Soc Trans (1990) 18 (5): 994–995.
Role of substrate availability on net l-lactate uptake by liver of fed and 24-h-starved rats
Biochem Soc Trans (1990) 18 (5): 995–996.
Identification of an NAD-dependent 3-acetamidobenzamide-sensitive system in oncospheres from the tapeworm Hymenolepis diminuta
Biochem Soc Trans (1990) 18 (5): 997–998.
Transfection of cos cells by normal and mutant α1-antitrypsin cDNA constructs: biochemical and immunocytochemical findings
Biochem Soc Trans (1990) 18 (5): 998–999.
Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma
Biochem Soc Trans (1990) 18 (5): 999–1000.
Comparative effects of pancuronium and vecuronium on rat diaphragm and isolated hepatocytes
Biochem Soc Trans (1990) 18 (5): 1001.
An assay for lanosterol 14α-demethylase from Saccharomyces cerevisiae
Biochem Soc Trans (1990) 18 (5): 1001–1002.
Expression of lipoprotein lipase mRNA during the differentiation of rat adipocyte precursor cells in vitro
Biochem Soc Trans (1990) 18 (5): 1002–1003.
Separate peroxisomal acyl-CoA oxidases for fatty acids and trihydroxycoprostanic acid in human liver
Biochem Soc Trans (1990) 18 (5): 1003–1004.
A differential effect of phorbol ester on the internalization of iron and transferrin by HL60 cells
Biochem Soc Trans (1990) 18 (5): 1005–1006.
Involvement of polyamines in pancreatic growth induced by dietary soyabean, lectin or trypsin inhibitors
Biochem Soc Trans (1990) 18 (5): 1009–1010.
Parathyroid hormone raises the Pi concentration in a cultured osteoblast model
Biochem Soc Trans (1990) 18 (5): 1010–1011.
Overproduction and isolation of elongation factor Tu using Escherichia coli grown on protiated and deuterated succinate
Biochem Soc Trans (1990) 18 (5): 1011–1012.
Phosphoglucoisomerase (neuroleukin), fibroblast growth factor and catalase: lack of neuronotrophic activity for cultured rat spinal neurones
Biochem Soc Trans (1990) 18 (5): 1012–1013.
Effect of exposure to β-aminopropionitrile on streptozotocin diabetic rats
Biochem Soc Trans (1990) 18 (5): 1013–1014.
Interactions of a model block copolymer drug delivery system with two serum proteins and myoglobin
Biochem Soc Trans (1990) 18 (5): 1021–1022.
Stimulation and inhibition of matrix metalloproteinase activities in articular cartilage
Biochem Soc Trans (1990) 18 (5): 1022–1023.
A biosynthetic study of meprin: a mouse renal microvillar membrane metallo-endopeptidase
Biochem Soc Trans (1990) 18 (5): 1026–1027.
Characterization of soluble 5-hydroxytryptamine3 receptors from N1E115 neuroblastoma cells
Biochem Soc Trans (1990) 18 (5): 1027–1028.
Structural studies on recombinant human ferritins
STEPHEN J. YEWDALL; DAVID M. LAWSON; PETER J. ARTYMIUK; AMYRA TREFFRY; PAULINE M. HARRISON; ALESSANDRA LUZZAGO; GIANNI CESARENI; SONIA LEVI; PAOLO AROSIO
Biochem Soc Trans (1990) 18 (5): 1028–1029.
A preliminary investigation of the hydrodynamic properties of two novel monoclonal antibodies
Biochem Soc Trans (1990) 18 (5): 1030–1031.
Changes in the pattern of cell surface proteins during transformation of bloodstream forms of Trypanosoma brucei in vitro
Biochem Soc Trans (1990) 18 (5): 1032–1033.
Regulation of Metabolism during the Starved to Fed Transition
Role of thyroid hormones in the regulation of hepatic glucokinase and phosphoenolpyruvate-carboxykinase gene expression during the starvation-refeeding transition
Biochem Soc Trans (1990) 18 (5): 845–847.
Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis
Biochem Soc Trans (1990) 18 (5): 851–853.
The lactating mammary gland of the rat and the starved-refed transition: a model system for the study of the temporal regulation of substrate utilization
Biochem Soc Trans (1990) 18 (5): 853–856.
Membrane Molecular Architecture and Function
Carbohydrates of the cellular surface: organization and dynamics as seen by 2H n.m.r.
Biochem Soc Trans (1990) 18 (5): 825–827.
Influence of chain unsaturation and chain position on thermotropism and intermolecular interactions in membranes
Biochem Soc Trans (1990) 18 (5): 835–837.
Comparison of frozen-hydrated and negatively stained crystals of Ca-ATPase suggests a shape for the intramembranous domain
Biochem Soc Trans (1990) 18 (5): 841–843.
Structure, Biology and Pathology of Proteoglycans
Structural aspects of skeletal keratan sulphates
IAN A. NIEDUSZYNSKI; THOMAS N. HUCKERBY; JOHN M. DICKENSON; GAVIN M. BROWN; TAI GUI-HUA; MICHAEL T. BAYLISS
Biochem Soc Trans (1990) 18 (5): 792–793.
Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases
Biochem Soc Trans (1990) 18 (5): 796–799.
Proteoglycan structure and metabolism during maturation and ageing of human articular cartilage
Biochem Soc Trans (1990) 18 (5): 799–802.
The gene that encodes the peptide core of secretory granule proteoglycans of haematopoietic cells
Biochem Soc Trans (1990) 18 (5): 810–812.
Role and regulation of metalloproteinases in connective tissue turnover
Biochem Soc Trans (1990) 18 (5): 812–815.
Heparan sulphate proteoglycans on rat parathyroid cells recycle in low Ca2+ medium
Biochem Soc Trans (1990) 18 (5): 816–818.
Immunological and molecular approaches to the study of basement membrane proteoglycan diversity
Biochem Soc Trans (1990) 18 (5): 819–820.
Monoclonal antibodies against chondroitin sulphate isomers: their use as probes for investigating proteoglycan metabolism
Biochem Soc Trans (1990) 18 (5): 820–823.
Metabolism of n − 6 and n − 3 Fatty Acids in Man and Animals
Potential diagnostic value of the umbilical artery as a definition of neural fatty acid status of the fetus during its growth: the umbilical artery as a diagnostic tool
Biochem Soc Trans (1990) 18 (5): 761–766.
Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans
Biochem Soc Trans (1990) 18 (5): 766–769.
Structural and enzymological properties of cellular phospholipases A2
HENK VAN DEN BOSCH; ANTON J. AARSMAN; RON H. N. VAN SCHAIK; CASPER G. SCHALKWIJK; FRED W. NEIJS; AUGUESTE STURK
Biochem Soc Trans (1990) 18 (5): 781–785.
Biochemical Approaches to Drug Targeting
Bacterial pathogens — a route to oral drug delivery
GORDON DOUGAN; STEVE CHATFIELD; MARK ROBERTS; IAN CHARLES; SARAH COMERFORD; LI JING LI; NEIL FAIRWEATHER
Biochem Soc Trans (1990) 18 (5): 746–748.
Drug targeting by endogenous transport vehicles
THEO J. C. VAN BERKEL; PASSCHIER C. DE SMIDT; MARC C. M. VAN DIJK; GIJBERTUS J. ZIERE; MARTIN K. BIJSTERBOSCH
Biochem Soc Trans (1990) 18 (5): 748–750.
Biodegradable azopolymer coating for oral delivery of peptide drugs
Biochem Soc Trans (1990) 18 (5): 752–754.
Biochemistry of Trypanosomes
Stage-specific mechanisms for activation and expression of variant surface glycoprotein genes in Trypanosoma brucei
Biochem Soc Trans (1990) 18 (5): 708–710.
Transcription analysis in Trypanosoma brucei
ALBERT W. C. A. CORNELISSEN; SILKE BACKES; RAYMOND EVERS; ERNST J. M. GRONDAL; WALDEMAR JESS; JOSEF KÖCK
Biochem Soc Trans (1990) 18 (5): 710–714.
The cell cycle and cytoskeletal morphogenesis in Trypanosoma brucei
KEITH GULL; CHRISTOPHER BIRKETT; ROGER GERKE-BONET; ALBERTO PARMA; DERRICK ROBINSON; TREVOR SHERWIN; ROBERT WOODWARD
Biochem Soc Trans (1990) 18 (5): 720–722.
Biosynthesis of the glycosyl phosphatidylinositol anchor of Trypanosoma brucei variant surface glycoprotein
Biochem Soc Trans (1990) 18 (5): 722–724.
Cloning of the 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei by complementation in Escherichia coli
Biochem Soc Trans (1990) 18 (5): 724–727.
Organization, structure and evolutionary aspects of genes in trypanosomes
Biochem Soc Trans (1990) 18 (5): 727–729.
Characterization of Trypanosoma brucei protein kinases and a growth factor receptor
Biochem Soc Trans (1990) 18 (5): 733–735.
Bioenergetic studies of bloodstream forms of Trypanosoma brucei: electrical and H+ gradients
Biochem Soc Trans (1990) 18 (5): 735–739.
Control of surface antigen genes in African trypanosomes
PIET BORST; JANET H. GOMMERS-AMPT; JAN LUTGERINK; MARC OUELLETTE; ANNELOOR L. M. A. TEN ASBROEK; JOOST C. B. M. ZOMERDIJK
Biochem Soc Trans (1990) 18 (5): 741–742.