The 3′ untranslated region (3′UTR) of mRNA plays a key role in the post-transcriptional regulation of gene expression. Most eukaryotic protein-coding genes express 3′UTR isoforms owing to alternative cleavage and polyadenylation (APA). The 3′UTR isoform expression profile of a cell changes in cell proliferation, differentiation, and stress conditions. Here, we review the emerging theme of regulation of 3′UTR isoforms in cell metabolic reprogramming, focusing on cell growth and autophagy responses through the mTOR pathway. We discuss regulatory events that converge on the Cleavage Factor I complex, a master regulator of APA in 3′UTRs, and recent understandings of isoform-specific m6A modification and endomembrane association in determining differential metabolic fates of 3′UTR isoforms.
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June 2023
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Phagocytosis involves the engulfment and digestion of detrimental foreign objects (e.g., microbes) by different immune cells of our body, such as macrophages. Lipids play an important role during this immunological process, and hence, microbes have found ways to hijack these lipid pathways during phagocytosis to evade the immune system. For further information, see the review in this issue by Saharan and Kamat, pages 1279–1287. Image provided by Siddhesh Shashikant Kamat.
Review Article|
May 12 2023
The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism
Biochem Soc Trans (2023) 51 (3): 1111–1119.
Article history
Received:
January 12 2023
Revision Received:
March 26 2023
Accepted:
April 19 2023
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