The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.
Skip Nav Destination
Article navigation
December 2021
-
Cover Image
Cover Image
Fuelled by the ‘resolution revolution’, cryo-EM has transformed our molecular understanding of transcriptional regulation in bacteria. As an example, Wood and colleagues (pp. 2695–2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. “E. coli Bacteria” by NIAID is licensed under CC BY 2.0. Cover artwork courtesy of Christopher Horne.
Review Article|
December 02 2021
Spatiotemporal regulation of store-operated calcium entry in cancer metastasis
Fujian Lu;
1State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
3Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, U.S.A.
Correspondence: Fujian Lu (fjlu@pku.edu.cn) or Shengyu Yang (sxy99@psu.edu)
Search for other works by this author on:
Yunzhan Li;
Yunzhan Li
2Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, U.S.A.
Search for other works by this author on:
Shengchen Lin;
Shengchen Lin
2Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, U.S.A.
Search for other works by this author on:
Heping Cheng;
Heping Cheng
1State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Search for other works by this author on:
Shengyu Yang
2Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, U.S.A.
Correspondence: Fujian Lu (fjlu@pku.edu.cn) or Shengyu Yang (sxy99@psu.edu)
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 14 2021
Revision Received:
November 09 2021
Accepted:
November 12 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem Soc Trans (2021) 49 (6): 2581–2589.
Article history
Received:
September 14 2021
Revision Received:
November 09 2021
Accepted:
November 12 2021
Citation
Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang; Spatiotemporal regulation of store-operated calcium entry in cancer metastasis. Biochem Soc Trans 17 December 2021; 49 (6): 2581–2589. doi: https://doi.org/10.1042/BST20210307
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.