Cancer is a significant cause of death, precluding increasing life expectancy worldwide. That is a multifactorial disease initiated by intrinsic or extrinsic factors that induce cell differentiation into cancer cells. However, cancer development, progression, and metastasis are not controlled only by cancer cells. The entire environment around these cells, named tumor microenvironment (TME), influences tumor development and spread. The tumor microenvironment is formed by cancer cells and heterogenous nonmalignant cells integrated with a complex extracellular matrix. The main cellular components of the TME are cancer-associated fibroblasts (CAFs), T lymphocytes, B cells, tumor-associated macrophages (TAMs), dendritic cells (DC), natural killer (NK) cells, tumor-associated neutrophils (TANs), Stem Cells, Endothelial Cells and their soluble secreted extracellular vesicles (EVs) that modulate cancer cells to establish and disseminate. This review provides a recent insight into the role of EVs secreted from different populations of the TME associated with the initiation and progression of carcinoma.
-
Cover Image
Cover Image
The cover of this edition of Biochemical Society Transactions features a super-resolution image of mouse heart mitochondria. Shammas, Huang and Narendra discuss the present understanding of neurodegeneration and myopathy caused by mutations in the mitochondrial proteins CHCHD2 and CHCHD10, and putting forth potential therapeutic strategies to combat these diseases in ‘CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy’ on pp 797-809.
Extracellular vesicles in carcinoma microenvironment
Larissa Tinô de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sá, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme; Extracellular vesicles in carcinoma microenvironment. Biochem Soc Trans 26 April 2023; 51 (2): 771–781. doi: https://doi.org/10.1042/BST20221175
Download citation file:
Sign in
Sign in to your personal account
Captcha Validation Error. Please try again.