Lipids comprise a diverse group of metabolites that are indispensable as energy storage molecules, cellular membrane components and mediators of inter- and intra-cellular signaling processes. Lipid homeostasis plays a crucial role in maintaining metabolic health in mammals including human beings. A growing body of evidence suggests that the circadian clock system ensures temporal orchestration of lipid homeostasis, and that perturbation of such diurnal regulation leads to the development of metabolic disorders comprising obesity and type 2 diabetes. In view of the emerging role of circadian regulation in maintaining lipid homeostasis, in this review, we summarize the current knowledge on lipid metabolic pathways controlled by the mammalian circadian system. Furthermore, we review the emerging connection between the development of human metabolic diseases and changes in lipid metabolites that belong to major classes of lipids. Finally, we highlight the mechanisms underlying circadian organization of lipid metabolic rhythms upon the physiological situation, and the consequences of circadian clock dysfunction for dysregulation of lipid metabolism.
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June 2022
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The pore-forming BCL-2 family proteins mediate mitochondrial poration to initiate apoptosis through protei–protein and protein–lipid interactions. Structural biology has been used to elucidate their mechanisms of activation, dimerization, and interaction with membranes, and AlphaFold, which relies solely on sequence information, can accurately predict the activated states, from Moldoveanu and colleagues, pages 35 to 47.
Review Article|
May 23 2022
Circadian rhythm of lipid metabolism
Flore Sinturel
;
1Division of Thoracic and Endocrine Surgery, Department of Surgery, University Hospital of Geneva, Geneva 1211, Switzerland
2Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
3Diabetes Center, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
4Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva 1211, Switzerland
Correspondence: Flore Sinturel (flore.sinturel@unige.ch)
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Weronika Spaleniak;
Weronika Spaleniak
5School of Pharmaceutical Sciences, University of Geneva, Geneva 1211, Switzerland
6Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva 1211, Switzerland
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Charna Dibner
Charna Dibner
1Division of Thoracic and Endocrine Surgery, Department of Surgery, University Hospital of Geneva, Geneva 1211, Switzerland
2Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
3Diabetes Center, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
4Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva 1211, Switzerland
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Publisher: Portland Press Ltd
Received:
March 31 2022
Revision Received:
April 29 2022
Accepted:
May 04 2022
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (3): 1191–1204.
Article history
Received:
March 31 2022
Revision Received:
April 29 2022
Accepted:
May 04 2022
Citation
Flore Sinturel, Weronika Spaleniak, Charna Dibner; Circadian rhythm of lipid metabolism. Biochem Soc Trans 30 June 2022; 50 (3): 1191–1204. doi: https://doi.org/10.1042/BST20210508
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