Obesity is caused by a combination of hereditary and environmental factors. Despite extensive study, contemporary through diet, exercise, education, surgery, and pharmacological treatments, no effective long-term solution has been found to this epidemic. Over the last decade, there has been a tremendous advancement in understanding the science of epigenetics, as well as a rise in public interest in learning more about the influence of diet and lifestyle choices on the health of an individual. Without affecting the underlying DNA sequence, epigenetic alterations impact gene expression. Previous animal studies have shown a link between the type of diet and expression or suppression of obesity genes, but there are very few human studies that demonstrate the relationship between dietary intake and obesity gene expression. This review highlights the effects of carbohydrates, lipids, and protein intake from the diet on obesity-related genes.
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February 2022
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The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
Review Article|
January 07 2022
Role of macronutrient intake in the epigenetics of obesity
Priyadarshni Patel;
Priyadarshni Patel
1Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, U.S.A.
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Jeganathan Ramesh Babu;
Jeganathan Ramesh Babu
1Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, U.S.A.
2Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL 36849, U.S.A.
3Alabama Agricultural Experiment Station, Auburn University, Auburn, AL 36849, U.S.A.
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Xu Wang;
Xu Wang
3Alabama Agricultural Experiment Station, Auburn University, Auburn, AL 36849, U.S.A.
4Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, U.S.A.
5HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, U.S.A.
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Thangiah Geetha
1Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, U.S.A.
2Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL 36849, U.S.A.
3Alabama Agricultural Experiment Station, Auburn University, Auburn, AL 36849, U.S.A.
Correspondence: Thangiah Geetha (thangge@auburn.edu)
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Publisher: Portland Press Ltd
Received:
September 06 2021
Revision Received:
December 06 2021
Accepted:
December 08 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (1): 487–497.
Article history
Received:
September 06 2021
Revision Received:
December 06 2021
Accepted:
December 08 2021
Citation
Priyadarshni Patel, Jeganathan Ramesh Babu, Xu Wang, Thangiah Geetha; Role of macronutrient intake in the epigenetics of obesity. Biochem Soc Trans 28 February 2022; 50 (1): 487–497. doi: https://doi.org/10.1042/BST20211069
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