Obesity and its associated metabolic diseases, including diabetes, insulin resistance, and inflammation, are rapidly becoming a global health concern. Moreover, obese individuals are more likely to be infected with COVID-19. New research on adipose tissue is required to help us understand these metabolic diseases and their regulatory processes. Recently, extracellular vesicles (EVs) have been identified as novel intercellular vectors with a wide range of regulatory functions. The miRNAs carried by EVs participate in the regulation of white adipose tissue (WAT) browning, insulin resistance, diabetes, and inflammation. In addition, EV miRNAs demonstrate great potential for helping elucidating the mechanism of metabolic diseases, and for advancing their prevention and treatment. In this review, we focus on the mechanisms underlying the regulation of adipose differentiation and metabolic diseases by adipose-derived EV miRNAs. Understanding the role of these miRNAs should enrich our understanding of the etiology and pathogenesis of metabolic diseases caused by obesity.
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February 2022
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Cover Image
Cover Image
The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
Review Article|
December 23 2021
Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesity
Le Zhao
;
Le Zhao
*
College of Animal Science and Technology; Chongqing Key Laboratory of Herbivore Science; Chongqing Key Laboratory of Forage & Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization; Chongqing Herbivore Engineering Research Center, Southwest University, Chongqing 400715, China
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Haili Yang;
Haili Yang
*
College of Animal Science and Technology; Chongqing Key Laboratory of Herbivore Science; Chongqing Key Laboratory of Forage & Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization; Chongqing Herbivore Engineering Research Center, Southwest University, Chongqing 400715, China
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Xingchun Li;
Xingchun Li
College of Animal Science and Technology; Chongqing Key Laboratory of Herbivore Science; Chongqing Key Laboratory of Forage & Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization; Chongqing Herbivore Engineering Research Center, Southwest University, Chongqing 400715, China
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Yongju Zhao
College of Animal Science and Technology; Chongqing Key Laboratory of Herbivore Science; Chongqing Key Laboratory of Forage & Herbivore; Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization; Chongqing Herbivore Engineering Research Center, Southwest University, Chongqing 400715, China
Correspondence: Yongju Zhao (zyongju@163.com)
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Publisher: Portland Press Ltd
Received:
August 18 2021
Revision Received:
December 09 2021
Accepted:
December 13 2021
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (1): 447–457.
Article history
Received:
August 18 2021
Revision Received:
December 09 2021
Accepted:
December 13 2021
Citation
Le Zhao, Haili Yang, Xingchun Li, Yongju Zhao; Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesity. Biochem Soc Trans 28 February 2022; 50 (1): 447–457. doi: https://doi.org/10.1042/BST20211031
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