Cofactor F420 is a low-potential hydride-transfer deazaflavin that mediates important oxidoreductive reactions in the primary metabolism of archaea and a wide range of bacteria. Over the past decade, biochemical studies have demonstrated another essential role for F420 in the biosynthesis of various classes of natural products. These studies have substantiated reports predating the structural determination of F420 that suggested a potential role for F420 in the biosynthesis of several antibiotics produced by Streptomyces. In this article, we focus on this exciting and emerging role of F420 in catalyzing the oxidoreductive transformation of various imine, ketone and enoate moieties in secondary metabolites. Given the extensive and increasing availability of genomic and metagenomic data, these F420-dependent transformations may lead to the discovery of novel secondary metabolites, providing an invaluable and untapped resource in various biotechnological applications.
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February 2022
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Cover Image
Cover Image
The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
Review Article|
February 22 2022
Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites
Ghader Bashiri
Laboratory of Molecular and Microbial Biochemistry, School of Biological Sciences, University of Auckland, Private Bag 92019 Auckland, New Zealand
Correspondence: Ghader Bashiri (g.bashiri@auckland.ac.nz)
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Publisher: Portland Press Ltd
Received:
December 11 2021
Revision Received:
February 03 2022
Accepted:
February 04 2022
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (1): 253–267.
Article history
Received:
December 11 2021
Revision Received:
February 03 2022
Accepted:
February 04 2022
Citation
Ghader Bashiri; Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites. Biochem Soc Trans 28 February 2022; 50 (1): 253–267. doi: https://doi.org/10.1042/BST20211286
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