Interleukin (IL)-36 is a subfamily, of the IL-1 super-family and includes IL-36α, IL-36β, IL-36γ, IL-38 and IL-36Ra. IL-36 cytokines are involved in the pathology of multiple tissues, including skin, lung, oral cavity, intestine, kidneys and joints. Recent studies suggest that IL-36 signaling regulates autoimmune disease in addition to antibacterial and antiviral responses. Most research has focused on IL-36 in skin diseases such as psoriasis, however, studies on intestinal diseases are also underway. This review outlines what is known about the bioactivity of the IL-36 subfamily and its role in the pathogenesis of intestinal diseases such as inflammatory bowel disease, colorectal cancer, gut dysbacteriosis and infection, and proposes that IL-36 may be a target for novel therapeutic strategies to prevent or treat intestinal diseases.
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February 2022
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The highly conserved enzyme IMPDH plays an essential role in purine biosynthesis and is tightly regulated by many different mechanisms. Depicted here are cryo-EM structures of the large retinal splice variant of IMPDH1 in different filament assembly conformations overlaid on a cryo-EM micrograph of IMPDH1 filaments. Cover artwork created by Jesse Hansen.
Review Article|
February 15 2022
The role of IL-36 subfamily in intestinal disease
Peng Xu;
Peng Xu
Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
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Haidi Guan;
Haidi Guan
Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
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Weidong Xiao;
Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
Correspondence: Lihua Sun (slh6260@163.com) or Weidong Xiao (xiaoweidong@tmmu.edu.cn)
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Lihua Sun
Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
Correspondence: Lihua Sun (slh6260@163.com) or Weidong Xiao (xiaoweidong@tmmu.edu.cn)
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Publisher: Portland Press Ltd
Received:
December 01 2021
Revision Received:
December 25 2021
Accepted:
January 06 2022
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2022
Biochem Soc Trans (2022) 50 (1): 223–230.
Article history
Received:
December 01 2021
Revision Received:
December 25 2021
Accepted:
January 06 2022
Citation
Peng Xu, Haidi Guan, Weidong Xiao, Lihua Sun; The role of IL-36 subfamily in intestinal disease. Biochem Soc Trans 28 February 2022; 50 (1): 223–230. doi: https://doi.org/10.1042/BST20211264
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